Fecal microbiota transplantation from Helicobacter pylori carriers following bismuth quadruple therapy exacerbates alcohol-related liver disease in mice via LPS-induced activation of hepatic TLR4/NF-κB/NLRP3 signaling

Fecal microbiota transplantation from Helicobacter pylori carriers following bismuth quadruple therapy exacerbates alcohol-related liver disease in mice via LPS-induced activation of hepatic TLR4/NF-κB/NLRP3 signaling

Abstract Background Helicobacter pylori infection is common in patients with alcohol-related liver disease (ALD), and bismuth quadruple therapy (BQT) is widely used for eradication. However, its impact on ALD remains unclear. This study aims to characterize BQT-induced gut microbiota alterations in...

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Bibliographic Details
Main Authors: Huihui Gao, Hangming Bai, Yanyan Su, Yuting Gao, Hui Fang, Donghang Li, Youren Yu, Xing Lu, Dasheng Xia, Daqing Mao, Yi Luo
Format: Article
Language:English
Published: BMC 2025-06-01
Series:Journal of Translational Medicine
Subjects:
Alcohol-related liver disease
Bismuth quadruple therapy
Gut dysbiosis
Fecal microbiota transplantation
Helicobacter pylori eradication
Online Access:https://doi.org/10.1186/s12967-025-06573-5
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