The β-adrenergic receptor-SGK1 signaling pathway in brown adipocytes protects GOT1 from proteasomal degradation

The β-adrenergic receptor-SGK1 signaling pathway in brown adipocytes protects GOT1 from proteasomal degradation

The malate-aspartate shuttle (MAS) is a key biochemical system that facilitates the transfer of reducing equivalents from the cytosol into mitochondria. It consists of two pairs of cytosolic and mitochondrial enzymes: glutamic-oxaloacetic transaminases (cGOT1, mGOT2) and malate dehydrogenases (cMDH1...

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Bibliographic Details
Main Authors: Chul-Hong Park, Minsung Park, J. Jason Collier, Ji Suk Chang
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-07-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
beta-adrenergic receptor
SGK1
GOT1
Brown adipose tissue (BAT)
malate-aspartate shuttle (MAS)
signaling/signaling pathways
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2025.1637770/full
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