Prognostic Value of B7-H3 and a Novel Scoring System in Localized Renal Cell Carcinoma
<i>Background and Objectives</i>: Renal cell carcinoma (RCC) is a biologically heterogeneous malignancy, and traditional prognostic models often fail to provide accurate risk stratification. B7-H3 (CD276), an immune checkpoint molecule, has been implicated in RCC progression but remains...
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MDPI AG
2025-05-01
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| author | Faruk Recep Özalp Kutsal Yörükoğlu Eda Çalışkan Yıldırım Mehmet Uzun Erkut Demirciler Hüseyin Salih Semiz |
| author_facet | Faruk Recep Özalp Kutsal Yörükoğlu Eda Çalışkan Yıldırım Mehmet Uzun Erkut Demirciler Hüseyin Salih Semiz |
| author_sort | Faruk Recep Özalp |
| collection | DOAJ |
| description | <i>Background and Objectives</i>: Renal cell carcinoma (RCC) is a biologically heterogeneous malignancy, and traditional prognostic models often fail to provide accurate risk stratification. B7-H3 (CD276), an immune checkpoint molecule, has been implicated in RCC progression but remains underexplored as a prognostic biomarker. <i>Materials and Methods</i>: This retrospective study analyzed 52 patients with localized RCC who underwent nephrectomy. Immunohistochemical staining was used to assess B7-H3 expression. A novel prognostic scoring system, the Renal Immune Prognostic Index (RIPI), incorporating B7-H3 expression, tumor necrosis, tumor grade, and pathological staging, was developed and validated. Kaplan–Meier survival analysis and Cox proportional hazard models were employed to evaluate disease-free survival (DFS) and overall survival (OS). <i>Results</i>: High B7-H3 expression was significantly associated with shorter DFS (12 vs. 54 months; <i>p</i> = 0.001) and OS (70 vs. 123 months; <i>p</i> = 0.002). The RIPI demonstrated strong prognostic performance, stratifying the patients into distinct risk groups with a C-index of 0.82. The high-risk patients had a median DFS of 14 months, compared with 125 months in the low-risk group (<i>p</i> < 0.001). <i>Conclusions</i>: B7-H3 expression serves as a significant prognostic biomarker in localized RCC, correlating with poorer survival outcomes. The integration of B7-H3 into the RIPI enhances risk stratification by incorporating both molecular and pathological features. These findings support the incorporation of immune biomarkers into clinical practice and highlight B7-H3 as a potential target for novel therapeutic strategies in RCC. |
| format | Article |
| id | doaj-art-dbd69a6c5ef4437faf481049f5fadb44 |
| institution | DOAJ |
| issn | 1010-660X 1648-9144 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Medicina |
| spelling | doaj-art-dbd69a6c5ef4437faf481049f5fadb442025-08-20T03:14:42ZengMDPI AGMedicina1010-660X1648-91442025-05-0161586710.3390/medicina61050867Prognostic Value of B7-H3 and a Novel Scoring System in Localized Renal Cell CarcinomaFaruk Recep Özalp0Kutsal Yörükoğlu1Eda Çalışkan Yıldırım2Mehmet Uzun3Erkut Demirciler4Hüseyin Salih Semiz5Department of Medical Oncology, Faculty of Medicine, Dokuz Eylul University, 35340 Izmir, TurkeyDepartment of Pathology, Faculty of Medicine, Dokuz Eylul University, 35340 Izmir, TurkeyDepartment of Medical Oncology, Faculty of Medicine, Dokuz Eylul University, 35340 Izmir, TurkeyDepartment of Medical Oncology, Faculty of Medicine, Dokuz Eylul University, 35340 Izmir, TurkeyDepartment of Medical Oncology, Faculty of Medicine, Dokuz Eylul University, 35340 Izmir, TurkeyDepartment of Medical Oncology, Faculty of Medicine, Dokuz Eylul University, 35340 Izmir, Turkey<i>Background and Objectives</i>: Renal cell carcinoma (RCC) is a biologically heterogeneous malignancy, and traditional prognostic models often fail to provide accurate risk stratification. B7-H3 (CD276), an immune checkpoint molecule, has been implicated in RCC progression but remains underexplored as a prognostic biomarker. <i>Materials and Methods</i>: This retrospective study analyzed 52 patients with localized RCC who underwent nephrectomy. Immunohistochemical staining was used to assess B7-H3 expression. A novel prognostic scoring system, the Renal Immune Prognostic Index (RIPI), incorporating B7-H3 expression, tumor necrosis, tumor grade, and pathological staging, was developed and validated. Kaplan–Meier survival analysis and Cox proportional hazard models were employed to evaluate disease-free survival (DFS) and overall survival (OS). <i>Results</i>: High B7-H3 expression was significantly associated with shorter DFS (12 vs. 54 months; <i>p</i> = 0.001) and OS (70 vs. 123 months; <i>p</i> = 0.002). The RIPI demonstrated strong prognostic performance, stratifying the patients into distinct risk groups with a C-index of 0.82. The high-risk patients had a median DFS of 14 months, compared with 125 months in the low-risk group (<i>p</i> < 0.001). <i>Conclusions</i>: B7-H3 expression serves as a significant prognostic biomarker in localized RCC, correlating with poorer survival outcomes. The integration of B7-H3 into the RIPI enhances risk stratification by incorporating both molecular and pathological features. These findings support the incorporation of immune biomarkers into clinical practice and highlight B7-H3 as a potential target for novel therapeutic strategies in RCC.https://www.mdpi.com/1648-9144/61/5/867RCCprognostic scoresB7-H3UISSGRANT |
| spellingShingle | Faruk Recep Özalp Kutsal Yörükoğlu Eda Çalışkan Yıldırım Mehmet Uzun Erkut Demirciler Hüseyin Salih Semiz Prognostic Value of B7-H3 and a Novel Scoring System in Localized Renal Cell Carcinoma Medicina RCC prognostic scores B7-H3 UISS GRANT |
| title | Prognostic Value of B7-H3 and a Novel Scoring System in Localized Renal Cell Carcinoma |
| title_full | Prognostic Value of B7-H3 and a Novel Scoring System in Localized Renal Cell Carcinoma |
| title_fullStr | Prognostic Value of B7-H3 and a Novel Scoring System in Localized Renal Cell Carcinoma |
| title_full_unstemmed | Prognostic Value of B7-H3 and a Novel Scoring System in Localized Renal Cell Carcinoma |
| title_short | Prognostic Value of B7-H3 and a Novel Scoring System in Localized Renal Cell Carcinoma |
| title_sort | prognostic value of b7 h3 and a novel scoring system in localized renal cell carcinoma |
| topic | RCC prognostic scores B7-H3 UISS GRANT |
| url | https://www.mdpi.com/1648-9144/61/5/867 |
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