The Application of OCTA in Assessment of Anti-VEGF Therapy for Idiopathic Choroidal Neovascularization
Purpose. To assess the morphology of idiopathic choroidal neovascularization (ICNV) by optical coherence tomography angiography (OCTA) and determine the therapeutic effects of intravitreal antivascular endothelial growth factor (anti-VEGF). Method. Patients with naive ICNV were assessed by spectral...
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| Format: | Article |
| Language: | English |
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Wiley
2016-01-01
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| Series: | Journal of Ophthalmology |
| Online Access: | http://dx.doi.org/10.1155/2016/5608250 |
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| _version_ | 1849472948682883072 |
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| author | Qin Chen Xiaobing Yu Zihan Sun Hong Dai |
| author_facet | Qin Chen Xiaobing Yu Zihan Sun Hong Dai |
| author_sort | Qin Chen |
| collection | DOAJ |
| description | Purpose. To assess the morphology of idiopathic choroidal neovascularization (ICNV) by optical coherence tomography angiography (OCTA) and determine the therapeutic effects of intravitreal antivascular endothelial growth factor (anti-VEGF). Method. Patients with naive ICNV were assessed by spectral domain optical coherence tomography (SD-OCT) and OCTA in this observational study. The timing of observation was before treatment, 1 day after treatment with intravitreal anti-VEGF injection, and 1 month after the treatment. The central retina thickness (CRT) on SD-OCT, selected CNV area, and flow area on OCTA were measured. Results. A total of 17 eyes from 17 patients with ICNV were included in this study. OCTA showed visible irregular choroidal neovascularization with “tree-in-bud” form on outer retinal layer. After treatment, as well as in the 1-day follow-up, CNV decreased in size from the periphery, and the vessel density was reduced. As shown on OCTA, the selected CNV area and flow area were significantly reduced compared to pretreatment. The rate of CNV vessel area changes was higher on OCTA than the changes in CRT on SD-OCT at 1-day and 1-month follow-up. Conclusion. Intravitreal injection of anti-VEGF is effective for idiopathic choroidal neovascularization, and the treatment outcomes are observable after 1 day. OCTA provides a useful approach for monitoring and evaluating the treatment of intravitreal anti-VEGF for CNV. |
| format | Article |
| id | doaj-art-dbccbd58e40b4c05979a61b793e08f5d |
| institution | Kabale University |
| issn | 2090-004X 2090-0058 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Ophthalmology |
| spelling | doaj-art-dbccbd58e40b4c05979a61b793e08f5d2025-08-20T03:24:21ZengWileyJournal of Ophthalmology2090-004X2090-00582016-01-01201610.1155/2016/56082505608250The Application of OCTA in Assessment of Anti-VEGF Therapy for Idiopathic Choroidal NeovascularizationQin Chen0Xiaobing Yu1Zihan Sun2Hong Dai3The Fifth School of Clinical Medicine, Peking University, Beijing 100730, ChinaDepartment of Ophthalmology, Beijing Hospital, Beijing 100730, ChinaDepartment of Ophthalmology, Beijing Hospital, Beijing 100730, ChinaDepartment of Ophthalmology, Beijing Hospital, Beijing 100730, ChinaPurpose. To assess the morphology of idiopathic choroidal neovascularization (ICNV) by optical coherence tomography angiography (OCTA) and determine the therapeutic effects of intravitreal antivascular endothelial growth factor (anti-VEGF). Method. Patients with naive ICNV were assessed by spectral domain optical coherence tomography (SD-OCT) and OCTA in this observational study. The timing of observation was before treatment, 1 day after treatment with intravitreal anti-VEGF injection, and 1 month after the treatment. The central retina thickness (CRT) on SD-OCT, selected CNV area, and flow area on OCTA were measured. Results. A total of 17 eyes from 17 patients with ICNV were included in this study. OCTA showed visible irregular choroidal neovascularization with “tree-in-bud” form on outer retinal layer. After treatment, as well as in the 1-day follow-up, CNV decreased in size from the periphery, and the vessel density was reduced. As shown on OCTA, the selected CNV area and flow area were significantly reduced compared to pretreatment. The rate of CNV vessel area changes was higher on OCTA than the changes in CRT on SD-OCT at 1-day and 1-month follow-up. Conclusion. Intravitreal injection of anti-VEGF is effective for idiopathic choroidal neovascularization, and the treatment outcomes are observable after 1 day. OCTA provides a useful approach for monitoring and evaluating the treatment of intravitreal anti-VEGF for CNV.http://dx.doi.org/10.1155/2016/5608250 |
| spellingShingle | Qin Chen Xiaobing Yu Zihan Sun Hong Dai The Application of OCTA in Assessment of Anti-VEGF Therapy for Idiopathic Choroidal Neovascularization Journal of Ophthalmology |
| title | The Application of OCTA in Assessment of Anti-VEGF Therapy for Idiopathic Choroidal Neovascularization |
| title_full | The Application of OCTA in Assessment of Anti-VEGF Therapy for Idiopathic Choroidal Neovascularization |
| title_fullStr | The Application of OCTA in Assessment of Anti-VEGF Therapy for Idiopathic Choroidal Neovascularization |
| title_full_unstemmed | The Application of OCTA in Assessment of Anti-VEGF Therapy for Idiopathic Choroidal Neovascularization |
| title_short | The Application of OCTA in Assessment of Anti-VEGF Therapy for Idiopathic Choroidal Neovascularization |
| title_sort | application of octa in assessment of anti vegf therapy for idiopathic choroidal neovascularization |
| url | http://dx.doi.org/10.1155/2016/5608250 |
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