Deciphering a proliferation-essential gene signature based on CRISPR-Cas9 screening to predict prognosis and characterize the immune microenvironment in HNSCC

Deciphering a proliferation-essential gene signature based on CRISPR-Cas9 screening to predict prognosis and characterize the immune microenvironment in HNSCC

Abstract Background Head and neck squamous cell carcinoma (HNSCC) is a highly aggressive malignancy with a poor prognosis. Identifying reliable prognostic biomarkers and therapeutic targets is crucial for improving patient outcomes. This study aimed to systematically identify proliferation-essential...

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Bibliographic Details
Main Authors: Ke-ling Pang, Pian Li, Xiang-Rong Yao, Wen-Tao Xiao, Xing Ren, Jun-Yan He
Format: Article
Language:English
Published: BMC 2025-04-01
Series:BMC Cancer
Subjects:
Head and neck squamous cell carcinoma
CRISPR-Cas9 screening
Proliferation-essential genes
Prognostic signature
Tumor immune microenvironment
PSMC1
Online Access:https://doi.org/10.1186/s12885-025-14181-1
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