Scale up manufacturing approach for production of human induced pluripotent stem cell-derived islets using Vertical Wheel® bioreactors

Scale up manufacturing approach for production of human induced pluripotent stem cell-derived islets using Vertical Wheel® bioreactors

Abstract Advanced protocols show potential for human stem cells (SC)-derived islets generation under planar (2D) alone or three-dimensional (3D) cultures, but show challenges in scalability, cell loss, and batch-to-batch consistency. This study explores Vertical Wheel (VW)® bioreactor suspension tec...

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Main Authors: Nidheesh Dadheech, Mario Bermúdez de León, Zofia Czarnecka, Nerea Cuesta-Gomez, Ila Tewari Jasra, Rena Pawlick, Braulio Marfil-Garza, Sandhya Sapkota, Kevin Verhoeff, Haide Razavy, Perveen Anwar, Abhineet Singh, Nilanjan Ray, Doug O’ Gorman, Glen Jickling, James Lyon, Patrick MacDonald, A. M. James Shapiro
Format: Article
Language:English
Published: Nature Portfolio 2025-05-01
Series:npj Regenerative Medicine
Online Access:https://doi.org/10.1038/s41536-025-00409-y
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