SIRT2 suppresses aging-associated cGAS activation and protects aged mice from severe COVID-19

SIRT2 suppresses aging-associated cGAS activation and protects aged mice from severe COVID-19

Summary: Aging-associated vulnerability to coronavirus disease 2019 (COVID-19) remains poorly understood. Here, we show that severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-infected aged mice lacking SIRT2, a cytosolic NAD+-dependent deacetylase, develop more severe disease and show inc...

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Main Authors: Marine Barthez, Biyun Xue, Jian Zheng, Yifei Wang, Zehan Song, Wei-Chieh Mu, Chih-ling Wang, Jiayue Guo, Fanghan Yang, Yuze Ma, Xuetong Wei, Chengjin Ye, Nicholas Sims, Luis Martinez-Sobrido, Stanley Perlman, Danica Chen
Format: Article
Language:English
Published: Elsevier 2025-04-01
Series:Cell Reports
Subjects:
CP: Immunology
CP: Microbiology
Online Access:http://www.sciencedirect.com/science/article/pii/S221112472500333X
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