Invariant NKT Cells as Novel Targets for Immunotherapy in Solid Tumors
Natural killer T (NKT) cells are a small population of lymphocytes that possess characteristics of both innate and adaptive immune cells. They are uniquely poised to respond rapidly to infection and inflammation and produce cytokines that critically shape the ensuing adaptive cellular response. Ther...
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | Clinical and Developmental Immunology |
| Online Access: | http://dx.doi.org/10.1155/2012/720803 |
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| _version_ | 1832563322312982528 |
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| author | Karsten A. Pilones Joseph Aryankalayil Sandra Demaria |
| author_facet | Karsten A. Pilones Joseph Aryankalayil Sandra Demaria |
| author_sort | Karsten A. Pilones |
| collection | DOAJ |
| description | Natural killer T (NKT) cells are a small population of lymphocytes that possess characteristics of both innate and adaptive immune cells. They are uniquely poised to respond rapidly to infection and inflammation and produce cytokines that critically shape the ensuing adaptive cellular response. Therefore, they represent promising therapeutic targets. In cancer, NKT cells are attributed a role in immunosurveillance. NKT cells also act as potent activators of antitumor immunity when stimulated with a synthetic agonist in experimental models. However, in some settings, NKT cells seem to act as suppressors and regulators of antitumor immunity. Here we briefly review current data supporting these paradoxical roles of NKT cells and their regulation. Increased understanding of the signals that determine the function of NKT cells in cancer will be essential to improve current strategies for NKT-cell-based immunotherapeutic approaches. |
| format | Article |
| id | doaj-art-dbc12cc63b9144dbb8969bf6c7a887d5 |
| institution | Kabale University |
| issn | 1740-2522 1740-2530 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Clinical and Developmental Immunology |
| spelling | doaj-art-dbc12cc63b9144dbb8969bf6c7a887d52025-02-03T01:20:33ZengWileyClinical and Developmental Immunology1740-25221740-25302012-01-01201210.1155/2012/720803720803Invariant NKT Cells as Novel Targets for Immunotherapy in Solid TumorsKarsten A. Pilones0Joseph Aryankalayil1Sandra Demaria2Department of Pathology, NYU School of Medicine, 550 First Avenue, MSB-521, New York, NY 10016, USADepartment of Pathology, NYU School of Medicine, 550 First Avenue, MSB-521, New York, NY 10016, USADepartment of Pathology, NYU School of Medicine, 550 First Avenue, MSB-521, New York, NY 10016, USANatural killer T (NKT) cells are a small population of lymphocytes that possess characteristics of both innate and adaptive immune cells. They are uniquely poised to respond rapidly to infection and inflammation and produce cytokines that critically shape the ensuing adaptive cellular response. Therefore, they represent promising therapeutic targets. In cancer, NKT cells are attributed a role in immunosurveillance. NKT cells also act as potent activators of antitumor immunity when stimulated with a synthetic agonist in experimental models. However, in some settings, NKT cells seem to act as suppressors and regulators of antitumor immunity. Here we briefly review current data supporting these paradoxical roles of NKT cells and their regulation. Increased understanding of the signals that determine the function of NKT cells in cancer will be essential to improve current strategies for NKT-cell-based immunotherapeutic approaches.http://dx.doi.org/10.1155/2012/720803 |
| spellingShingle | Karsten A. Pilones Joseph Aryankalayil Sandra Demaria Invariant NKT Cells as Novel Targets for Immunotherapy in Solid Tumors Clinical and Developmental Immunology |
| title | Invariant NKT Cells as Novel Targets for Immunotherapy in Solid Tumors |
| title_full | Invariant NKT Cells as Novel Targets for Immunotherapy in Solid Tumors |
| title_fullStr | Invariant NKT Cells as Novel Targets for Immunotherapy in Solid Tumors |
| title_full_unstemmed | Invariant NKT Cells as Novel Targets for Immunotherapy in Solid Tumors |
| title_short | Invariant NKT Cells as Novel Targets for Immunotherapy in Solid Tumors |
| title_sort | invariant nkt cells as novel targets for immunotherapy in solid tumors |
| url | http://dx.doi.org/10.1155/2012/720803 |
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