Cognitive Phenotypes, Brain Morphometry and the Detection of Cognitive Decline in Preclinical AD
Identifying a preclinical phase of Alzheimer’s Disease (PCAD) that is distinct from cognitive changes in healthy aging continues to be a major research focus. Combining neuropsychological and neuroimaging methodologies should improve our ability to differentiate healthy from pathological aging, alth...
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| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2009-01-01
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| Series: | Behavioural Neurology |
| Online Access: | http://dx.doi.org/10.3233/BEN-2009-0229 |
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| _version_ | 1832556920787959808 |
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| author | Mark W. Jacobson Linda K. McEvoy Anders Dale Christine Fennema-Notestine |
| author_facet | Mark W. Jacobson Linda K. McEvoy Anders Dale Christine Fennema-Notestine |
| author_sort | Mark W. Jacobson |
| collection | DOAJ |
| description | Identifying a preclinical phase of Alzheimer’s Disease (PCAD) that is distinct from cognitive changes in healthy aging continues to be a major research focus. Combining neuropsychological and neuroimaging methodologies should improve our ability to differentiate healthy from pathological aging, although studies that utilize both methods often result in equivocal findings, possibly due to variability in cognitive test performance that may be capturing distinct phenotypes. One method of capturing this cognitive variability is to utilize contrasting neuropsychological tests to identify subgroups representative of distinct cognitive phenotypes, and determine whether differences in brain morphometry support these classifications. We review several approaches to defining cognitive subgroups, and we consider the possibility that cognitive asymmetry might provide one means of identifying both functional and structural changes associated with aging and dementia. |
| format | Article |
| id | doaj-art-dbc0554284b74204a9fd39948cd01021 |
| institution | Kabale University |
| issn | 0953-4180 1875-8584 |
| language | English |
| publishDate | 2009-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Behavioural Neurology |
| spelling | doaj-art-dbc0554284b74204a9fd39948cd010212025-02-03T05:44:11ZengWileyBehavioural Neurology0953-41801875-85842009-01-01211-2293710.3233/BEN-2009-0229Cognitive Phenotypes, Brain Morphometry and the Detection of Cognitive Decline in Preclinical ADMark W. Jacobson0Linda K. McEvoy1Anders Dale2Christine Fennema-Notestine3Veterans Affairs San Diego Healthcare System, San Diego, CA, USADepartment of Radiology, University of California San Diego, San Diego, CA, USADepartment of Neurosciences, University of California San Diego, San Diego, CA, USADepartment of Psychiatry, University of California San Diego, San Diego, CA, USAIdentifying a preclinical phase of Alzheimer’s Disease (PCAD) that is distinct from cognitive changes in healthy aging continues to be a major research focus. Combining neuropsychological and neuroimaging methodologies should improve our ability to differentiate healthy from pathological aging, although studies that utilize both methods often result in equivocal findings, possibly due to variability in cognitive test performance that may be capturing distinct phenotypes. One method of capturing this cognitive variability is to utilize contrasting neuropsychological tests to identify subgroups representative of distinct cognitive phenotypes, and determine whether differences in brain morphometry support these classifications. We review several approaches to defining cognitive subgroups, and we consider the possibility that cognitive asymmetry might provide one means of identifying both functional and structural changes associated with aging and dementia.http://dx.doi.org/10.3233/BEN-2009-0229 |
| spellingShingle | Mark W. Jacobson Linda K. McEvoy Anders Dale Christine Fennema-Notestine Cognitive Phenotypes, Brain Morphometry and the Detection of Cognitive Decline in Preclinical AD Behavioural Neurology |
| title | Cognitive Phenotypes, Brain Morphometry and the Detection of Cognitive Decline in Preclinical AD |
| title_full | Cognitive Phenotypes, Brain Morphometry and the Detection of Cognitive Decline in Preclinical AD |
| title_fullStr | Cognitive Phenotypes, Brain Morphometry and the Detection of Cognitive Decline in Preclinical AD |
| title_full_unstemmed | Cognitive Phenotypes, Brain Morphometry and the Detection of Cognitive Decline in Preclinical AD |
| title_short | Cognitive Phenotypes, Brain Morphometry and the Detection of Cognitive Decline in Preclinical AD |
| title_sort | cognitive phenotypes brain morphometry and the detection of cognitive decline in preclinical ad |
| url | http://dx.doi.org/10.3233/BEN-2009-0229 |
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