Cajaninstilbene Acid and Its Derivative as Multi-Therapeutic Agents: A Comprehensive Review
Pigeon pea (<i>Cajanus cajan</i> (L.) Millsp.) is a traditional Chinese medicinal plant widely utilized in folk medicine due to its significant pharmacological and nutritional properties. Cajaninstilbene acid (CSA), a stilbene compound derived from pigeon pea leaves, has been extensively...
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MDPI AG
2024-11-01
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| Series: | Molecules |
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| Online Access: | https://www.mdpi.com/1420-3049/29/22/5440 |
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| author | Wen Hou Lejun Huang Jinyang Wang Walter Luyten Jia Lai Zhinuo Zhou Sishuang Kang Ping Dai Yanzhu Wang Hao Huang Jinxia Lan |
| author_facet | Wen Hou Lejun Huang Jinyang Wang Walter Luyten Jia Lai Zhinuo Zhou Sishuang Kang Ping Dai Yanzhu Wang Hao Huang Jinxia Lan |
| author_sort | Wen Hou |
| collection | DOAJ |
| description | Pigeon pea (<i>Cajanus cajan</i> (L.) Millsp.) is a traditional Chinese medicinal plant widely utilized in folk medicine due to its significant pharmacological and nutritional properties. Cajaninstilbene acid (CSA), a stilbene compound derived from pigeon pea leaves, has been extensively investigated since the 1980s. A thorough understanding of CSA’s mechanisms of action and its therapeutic effects on various diseases is crucial for developing novel therapeutic approaches. This paper presents an overview of recent research advancements concerning the biological activities and mechanisms of CSA and its derivatives up to February 2024. The review encompasses discussions on the in vivo metabolism of CSA and its derivatives, including antipathogenic micro-organisms activity, anti-tumor activity, systematic and organ protection activity (such as bone protection, cardiovascular protection, neuroprotection), anti-inflammatory activity, antioxidant activity, immune regulation as well as action mechanism of CSA and its derivatives. The most studied activities are antipathogenic micro-organisms activities. Additionally, the structure–activity relationships of CSA and its derivatives as well as the total synthesis of CSA are explored, highlighting the potential for developing new pharmaceutical agents. This review aims to provide a foundation for future clinical applications of CSA and its derivatives. |
| format | Article |
| id | doaj-art-dbbe53e4f8924dc790202f47980d82e1 |
| institution | OA Journals |
| issn | 1420-3049 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj-art-dbbe53e4f8924dc790202f47980d82e12025-08-20T02:04:59ZengMDPI AGMolecules1420-30492024-11-012922544010.3390/molecules29225440Cajaninstilbene Acid and Its Derivative as Multi-Therapeutic Agents: A Comprehensive ReviewWen Hou0Lejun Huang1Jinyang Wang2Walter Luyten3Jia Lai4Zhinuo Zhou5Sishuang Kang6Ping Dai7Yanzhu Wang8Hao Huang9Jinxia Lan10Jiangxi Province Key Laboratory of Pharmacology of Traditional Chinese Medicine, School of Pharmacy, Gannan Medical University, Ganzhou 341000, ChinaSchool of Rehabilitation, Gannan Medical University, Ganzhou 341000, ChinaJiangxi Province Key Laboratory of Pharmacology of Traditional Chinese Medicine, School of Pharmacy, Gannan Medical University, Ganzhou 341000, ChinaDepartment of Biology, Animal Physiology and Neurobiology Section, KU Leuven, 3000 Leuven, BelgiumJiangxi Province Key Laboratory of Pharmacology of Traditional Chinese Medicine, School of Pharmacy, Gannan Medical University, Ganzhou 341000, ChinaJiangxi Province Key Laboratory of Pharmacology of Traditional Chinese Medicine, School of Pharmacy, Gannan Medical University, Ganzhou 341000, ChinaJiangxi Province Key Laboratory of Pharmacology of Traditional Chinese Medicine, School of Pharmacy, Gannan Medical University, Ganzhou 341000, ChinaJiangxi Province Key Laboratory of Pharmacology of Traditional Chinese Medicine, School of Pharmacy, Gannan Medical University, Ganzhou 341000, ChinaJiangxi Province Key Laboratory of Pharmacology of Traditional Chinese Medicine, School of Pharmacy, Gannan Medical University, Ganzhou 341000, ChinaJiangxi Province Key Laboratory of Pharmacology of Traditional Chinese Medicine, School of Pharmacy, Gannan Medical University, Ganzhou 341000, ChinaSchool of Public Health and Health Management, Gannan Medical University, Ganzhou 341000, ChinaPigeon pea (<i>Cajanus cajan</i> (L.) Millsp.) is a traditional Chinese medicinal plant widely utilized in folk medicine due to its significant pharmacological and nutritional properties. Cajaninstilbene acid (CSA), a stilbene compound derived from pigeon pea leaves, has been extensively investigated since the 1980s. A thorough understanding of CSA’s mechanisms of action and its therapeutic effects on various diseases is crucial for developing novel therapeutic approaches. This paper presents an overview of recent research advancements concerning the biological activities and mechanisms of CSA and its derivatives up to February 2024. The review encompasses discussions on the in vivo metabolism of CSA and its derivatives, including antipathogenic micro-organisms activity, anti-tumor activity, systematic and organ protection activity (such as bone protection, cardiovascular protection, neuroprotection), anti-inflammatory activity, antioxidant activity, immune regulation as well as action mechanism of CSA and its derivatives. The most studied activities are antipathogenic micro-organisms activities. Additionally, the structure–activity relationships of CSA and its derivatives as well as the total synthesis of CSA are explored, highlighting the potential for developing new pharmaceutical agents. This review aims to provide a foundation for future clinical applications of CSA and its derivatives.https://www.mdpi.com/1420-3049/29/22/5440<i>Cajanus cajan</i>cajaninstilbene acidantibacterial activitiesanti-tumoranti-inflammatory |
| spellingShingle | Wen Hou Lejun Huang Jinyang Wang Walter Luyten Jia Lai Zhinuo Zhou Sishuang Kang Ping Dai Yanzhu Wang Hao Huang Jinxia Lan Cajaninstilbene Acid and Its Derivative as Multi-Therapeutic Agents: A Comprehensive Review Molecules <i>Cajanus cajan</i> cajaninstilbene acid antibacterial activities anti-tumor anti-inflammatory |
| title | Cajaninstilbene Acid and Its Derivative as Multi-Therapeutic Agents: A Comprehensive Review |
| title_full | Cajaninstilbene Acid and Its Derivative as Multi-Therapeutic Agents: A Comprehensive Review |
| title_fullStr | Cajaninstilbene Acid and Its Derivative as Multi-Therapeutic Agents: A Comprehensive Review |
| title_full_unstemmed | Cajaninstilbene Acid and Its Derivative as Multi-Therapeutic Agents: A Comprehensive Review |
| title_short | Cajaninstilbene Acid and Its Derivative as Multi-Therapeutic Agents: A Comprehensive Review |
| title_sort | cajaninstilbene acid and its derivative as multi therapeutic agents a comprehensive review |
| topic | <i>Cajanus cajan</i> cajaninstilbene acid antibacterial activities anti-tumor anti-inflammatory |
| url | https://www.mdpi.com/1420-3049/29/22/5440 |
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