Association between Pan‐Immune Inflammation Value and Sarcopenia in Hypertensive Patients, NHANES 1999–2018
ABSTRACT Sarcopenia worsens the prognosis in hypertensive patients, leading to complications such as proteinuria, osteoporosis, disability, and cognitive impairment. Early screening and intervention for sarcopenia in these patients may improve outcomes. This cross‐sectional study utilized data from...
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| Format: | Article |
| Language: | English |
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Wiley
2025-01-01
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| Series: | The Journal of Clinical Hypertension |
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| Online Access: | https://doi.org/10.1111/jch.14944 |
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| author | Lu Long Bingquan Xiong Zhidan Luo Haiyan Yang Qiang She |
| author_facet | Lu Long Bingquan Xiong Zhidan Luo Haiyan Yang Qiang She |
| author_sort | Lu Long |
| collection | DOAJ |
| description | ABSTRACT Sarcopenia worsens the prognosis in hypertensive patients, leading to complications such as proteinuria, osteoporosis, disability, and cognitive impairment. Early screening and intervention for sarcopenia in these patients may improve outcomes. This cross‐sectional study utilized data from 9253 hypertensive patients in the 1999–2018 National Health and Nutrition Examination Survey (NHANES). We used logistic and linear regression models, restricted cubic splines (RCS), and subgroup analyses to evaluate the relationship between pan‐immune‐inflammation value (PIV) and sarcopenia. Patients were divided into quartiles based on PIV levels. After controlling for confounding factors, our study found that those in the highest PIV quartile faced a 36% greater risk of developing sarcopenia compared to those in the lowest quartile (OR = 1.36, 95% confidence interval [CI]: 1.04–1.77). The RCS analysis indicated a linear increase in sarcopenia risk as PIV levels rose (non‐linear p = 0.130). Subgroup analysis demonstrated that diabetes synergistically increased sarcopenia risk (p for interaction = 0.007). Elevated PIV levels were identified as an independent risk factor for sarcopenia, with diabetes amplifying this risk. These findings highlight the importance of early identification and management of elevated PIV levels to improve outcomes for hypertensive patients at risk of sarcopenia. |
| format | Article |
| id | doaj-art-dbb655ae29a84f7e882b8478e749681a |
| institution | Kabale University |
| issn | 1524-6175 1751-7176 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | The Journal of Clinical Hypertension |
| spelling | doaj-art-dbb655ae29a84f7e882b8478e749681a2025-01-31T05:38:36ZengWileyThe Journal of Clinical Hypertension1524-61751751-71762025-01-01271n/an/a10.1111/jch.14944Association between Pan‐Immune Inflammation Value and Sarcopenia in Hypertensive Patients, NHANES 1999–2018Lu Long0Bingquan Xiong1Zhidan Luo2Haiyan Yang3Qiang She4Department of Cardiology The Second Affiliated Hospital of Chongqing Medical University Chongqing ChinaDepartment of Cardiology The Second Affiliated Hospital of Chongqing Medical University Chongqing ChinaDepartment of Geriatrics, Chongqing General Hospital Chongqing University Chongqing ChinaDepartment of Geriatrics, Chongqing General Hospital Chongqing University Chongqing ChinaDepartment of Cardiology The Second Affiliated Hospital of Chongqing Medical University Chongqing ChinaABSTRACT Sarcopenia worsens the prognosis in hypertensive patients, leading to complications such as proteinuria, osteoporosis, disability, and cognitive impairment. Early screening and intervention for sarcopenia in these patients may improve outcomes. This cross‐sectional study utilized data from 9253 hypertensive patients in the 1999–2018 National Health and Nutrition Examination Survey (NHANES). We used logistic and linear regression models, restricted cubic splines (RCS), and subgroup analyses to evaluate the relationship between pan‐immune‐inflammation value (PIV) and sarcopenia. Patients were divided into quartiles based on PIV levels. After controlling for confounding factors, our study found that those in the highest PIV quartile faced a 36% greater risk of developing sarcopenia compared to those in the lowest quartile (OR = 1.36, 95% confidence interval [CI]: 1.04–1.77). The RCS analysis indicated a linear increase in sarcopenia risk as PIV levels rose (non‐linear p = 0.130). Subgroup analysis demonstrated that diabetes synergistically increased sarcopenia risk (p for interaction = 0.007). Elevated PIV levels were identified as an independent risk factor for sarcopenia, with diabetes amplifying this risk. These findings highlight the importance of early identification and management of elevated PIV levels to improve outcomes for hypertensive patients at risk of sarcopenia.https://doi.org/10.1111/jch.14944diabeteshypertensionNational Health and Nutrition Examination Surveys (NHANES)pan‐immune‐inflammation value (PIV)sarcopenia |
| spellingShingle | Lu Long Bingquan Xiong Zhidan Luo Haiyan Yang Qiang She Association between Pan‐Immune Inflammation Value and Sarcopenia in Hypertensive Patients, NHANES 1999–2018 The Journal of Clinical Hypertension diabetes hypertension National Health and Nutrition Examination Surveys (NHANES) pan‐immune‐inflammation value (PIV) sarcopenia |
| title | Association between Pan‐Immune Inflammation Value and Sarcopenia in Hypertensive Patients, NHANES 1999–2018 |
| title_full | Association between Pan‐Immune Inflammation Value and Sarcopenia in Hypertensive Patients, NHANES 1999–2018 |
| title_fullStr | Association between Pan‐Immune Inflammation Value and Sarcopenia in Hypertensive Patients, NHANES 1999–2018 |
| title_full_unstemmed | Association between Pan‐Immune Inflammation Value and Sarcopenia in Hypertensive Patients, NHANES 1999–2018 |
| title_short | Association between Pan‐Immune Inflammation Value and Sarcopenia in Hypertensive Patients, NHANES 1999–2018 |
| title_sort | association between pan immune inflammation value and sarcopenia in hypertensive patients nhanes 1999 2018 |
| topic | diabetes hypertension National Health and Nutrition Examination Surveys (NHANES) pan‐immune‐inflammation value (PIV) sarcopenia |
| url | https://doi.org/10.1111/jch.14944 |
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