ACSL4 predicts rapid kidney function decline in patients with diabetic kidney disease

ACSL4 predicts rapid kidney function decline in patients with diabetic kidney disease

BackgroundFerroptosis of kidney tubular epithelial cells contributes to the pathogenesis of diabetic kidney disease (DKD). An increase in the enzyme long-chain fatty acid CoA ligase 4 (ACSL4) favors ferroptosis. However, the association between ACSL4 in renal tubules and kidney outcomes of patients...

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Bibliographic Details
Main Authors: Rui Shen, Xin Yu, Caifeng Shi, Yi Fang, Chunsun Dai, Yang Zhou
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-03-01
Series:Frontiers in Endocrinology
Subjects:
ACSL4
diabetic kidney disease
eGFR slope
proteinuria
biopsy
Online Access:https://www.frontiersin.org/articles/10.3389/fendo.2025.1499555/full
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