Spatial and single cell mapping of castleman disease reveals key stromal cell types and cytokine pathways

Spatial and single cell mapping of castleman disease reveals key stromal cell types and cytokine pathways

Abstract To determine the cellular and molecular basis of Castleman Disease (CD), we analyze the spatial proteome and transcriptome from a discovery (n = 9 cases) and validation (n = 13 cases) cohort of Unicentric CD, idiopathic Multicentric CD, HHV8-associated MCD, and reactive lymph nodes. CD show...

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Main Authors: David Smith, Anna Eichinger, Éanna Fennell, Zijun Y. Xu-Monette, Andrew Rech, Julia Wang, Eduardo Esteva, Arta Seyedian, Xiaoxu Yang, Mei Zhang, Dan Martinez, Kai Tan, Minjie Luo, Katherine J. Young, Paul G. Murray, Christopher Park, Boris Reizis, Vinodh Pillai
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-61214-1
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