Descriptive epidemiology of Lassa fever, its trend, seasonality, and mortality predictors in Ebonyi State, South- East, Nigeria, 2018—2022
Abstract Background Nigeria is an epicenter for Lassa fever. Ebonyi state is located in the South-Eastern region of Nigeria where a high burden of Lassa fever has been reported. Therefore, this study was designed to assess the epidemiology of Lassa fever, its seasonality, trend, and mortality predic...
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2024-12-01
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| Online Access: | https://doi.org/10.1186/s12889-024-20840-y |
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| author | Adanna Ezenwa-Ahanene Adetokunbo T. Salawu Ayo S. Adebowale |
| author_facet | Adanna Ezenwa-Ahanene Adetokunbo T. Salawu Ayo S. Adebowale |
| author_sort | Adanna Ezenwa-Ahanene |
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| description | Abstract Background Nigeria is an epicenter for Lassa fever. Ebonyi state is located in the South-Eastern region of Nigeria where a high burden of Lassa fever has been reported. Therefore, this study was designed to assess the epidemiology of Lassa fever, its seasonality, trend, and mortality predictors in Ebonyi state, South-East, Nigeria. Method We analyzed data extracted from Ebonyi State Integrated Disease Surveillance and Response (IDSR) system over five years (2018–2022). A total of 1578 reported Lassa fever cases were captured in the IDSR out of which 300 were laboratory-confirmed. Data were analyzed using descriptive statistics, additive time series model, quadratic equation, and logistic regression model (α0.05). Spatial distribution of reported Lassa fever cases was conducted using Arc G.I.S. Results The mean age of the individuals with the reported cases of Lassa fever was 29.4 ± 17.8 years. Lassa fever showed a seasonal trend across the years. The quadratic model provided the best fit for predicting Lassa fever cumulative cases (R2 = 98.4%, P-value < 0.05). Projected cases of Lassa fever for the year 2023 were 123 in the 1st quarter, 23 in the 2nd quarter, 42 in the 3rd quarter, and 17 in the 4th quarter. The seasonality index was + 70.76, -28.42, -9.09, and -33.2 in the 1st, 2nd, 3rd, and 4th quarters respectively. The reported cases of Lassa fever followed a declining trend (slope = -0.1363). Farmers were 70% less likely to die from Lassa fever compared to those not working (aOR:0.3, CI: 0.17–0.83). The hot spots for Lassa fever were Abakaliki and Ezza Local Government Areas. Conclusion Although the reported Lassa fever cases followed a declining trend in Ebonyi state, there was a seasonality in the disease pattern. Being a farmer was protective against the risk of dying from Lassa fever. While efforts to eliminate and mitigate the spread of the disease in Ebonyi state should be strengthened, more attention should target the peak period of the disease. |
| format | Article |
| id | doaj-art-db9c8b672eb04dfba6368491eddeddbb |
| institution | OA Journals |
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| language | English |
| publishDate | 2024-12-01 |
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| spelling | doaj-art-db9c8b672eb04dfba6368491eddeddbb2025-08-20T01:57:13ZengBMCBMC Public Health1471-24582024-12-0124111310.1186/s12889-024-20840-yDescriptive epidemiology of Lassa fever, its trend, seasonality, and mortality predictors in Ebonyi State, South- East, Nigeria, 2018—2022Adanna Ezenwa-Ahanene0Adetokunbo T. Salawu1Ayo S. Adebowale2Department of Epidemiology and Medical Statistics, Faculty of Public Health, College of Medicine, University of IbadanDepartment of Epidemiology and Medical Statistics, Faculty of Public Health, College of Medicine, University of IbadanDepartment of Epidemiology and Medical Statistics, Faculty of Public Health, College of Medicine, University of IbadanAbstract Background Nigeria is an epicenter for Lassa fever. Ebonyi state is located in the South-Eastern region of Nigeria where a high burden of Lassa fever has been reported. Therefore, this study was designed to assess the epidemiology of Lassa fever, its seasonality, trend, and mortality predictors in Ebonyi state, South-East, Nigeria. Method We analyzed data extracted from Ebonyi State Integrated Disease Surveillance and Response (IDSR) system over five years (2018–2022). A total of 1578 reported Lassa fever cases were captured in the IDSR out of which 300 were laboratory-confirmed. Data were analyzed using descriptive statistics, additive time series model, quadratic equation, and logistic regression model (α0.05). Spatial distribution of reported Lassa fever cases was conducted using Arc G.I.S. Results The mean age of the individuals with the reported cases of Lassa fever was 29.4 ± 17.8 years. Lassa fever showed a seasonal trend across the years. The quadratic model provided the best fit for predicting Lassa fever cumulative cases (R2 = 98.4%, P-value < 0.05). Projected cases of Lassa fever for the year 2023 were 123 in the 1st quarter, 23 in the 2nd quarter, 42 in the 3rd quarter, and 17 in the 4th quarter. The seasonality index was + 70.76, -28.42, -9.09, and -33.2 in the 1st, 2nd, 3rd, and 4th quarters respectively. The reported cases of Lassa fever followed a declining trend (slope = -0.1363). Farmers were 70% less likely to die from Lassa fever compared to those not working (aOR:0.3, CI: 0.17–0.83). The hot spots for Lassa fever were Abakaliki and Ezza Local Government Areas. Conclusion Although the reported Lassa fever cases followed a declining trend in Ebonyi state, there was a seasonality in the disease pattern. Being a farmer was protective against the risk of dying from Lassa fever. While efforts to eliminate and mitigate the spread of the disease in Ebonyi state should be strengthened, more attention should target the peak period of the disease.https://doi.org/10.1186/s12889-024-20840-yLassa feverTime series analysisSeasonalityEbonyi State |
| spellingShingle | Adanna Ezenwa-Ahanene Adetokunbo T. Salawu Ayo S. Adebowale Descriptive epidemiology of Lassa fever, its trend, seasonality, and mortality predictors in Ebonyi State, South- East, Nigeria, 2018—2022 BMC Public Health Lassa fever Time series analysis Seasonality Ebonyi State |
| title | Descriptive epidemiology of Lassa fever, its trend, seasonality, and mortality predictors in Ebonyi State, South- East, Nigeria, 2018—2022 |
| title_full | Descriptive epidemiology of Lassa fever, its trend, seasonality, and mortality predictors in Ebonyi State, South- East, Nigeria, 2018—2022 |
| title_fullStr | Descriptive epidemiology of Lassa fever, its trend, seasonality, and mortality predictors in Ebonyi State, South- East, Nigeria, 2018—2022 |
| title_full_unstemmed | Descriptive epidemiology of Lassa fever, its trend, seasonality, and mortality predictors in Ebonyi State, South- East, Nigeria, 2018—2022 |
| title_short | Descriptive epidemiology of Lassa fever, its trend, seasonality, and mortality predictors in Ebonyi State, South- East, Nigeria, 2018—2022 |
| title_sort | descriptive epidemiology of lassa fever its trend seasonality and mortality predictors in ebonyi state south east nigeria 2018 2022 |
| topic | Lassa fever Time series analysis Seasonality Ebonyi State |
| url | https://doi.org/10.1186/s12889-024-20840-y |
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