Complementary Roles of Orexin and Melanin-Concentrating Hormone in Feeding Behavior
Transcribed within the lateral hypothalamus, the neuropeptides orexin/hypocretin (OX) and melanin-concentrating hormone (MCH) both promote palatable food intake and are stimulated by palatable food. While these two neuropeptides share this similar positive relationship with food, recent evidence sug...
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| Format: | Article |
| Language: | English |
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Wiley
2013-01-01
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| Series: | International Journal of Endocrinology |
| Online Access: | http://dx.doi.org/10.1155/2013/983964 |
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| author | Jessica R. Barson Irene Morganstern Sarah F. Leibowitz |
| author_facet | Jessica R. Barson Irene Morganstern Sarah F. Leibowitz |
| author_sort | Jessica R. Barson |
| collection | DOAJ |
| description | Transcribed within the lateral hypothalamus, the neuropeptides orexin/hypocretin (OX) and melanin-concentrating hormone (MCH) both promote palatable food intake and are stimulated by palatable food. While these two neuropeptides share this similar positive relationship with food, recent evidence suggests that this occurs through different albeit complementary effects on behavior, with OX promoting food seeking and motivation for palatable food and MCH functioning during ongoing food intake, reinforcing the consumption of calorically dense foods. Further differences are evident in their effects on physiological processes, which are largely opposite in nature. For example, activation of OX receptors, which is neuronally excitatory, promotes waking, increases energy expenditure, and enhances limbic dopamine levels and reward. In contrast, activation of MCH receptors, which is neuronally inhibitory, promotes paradoxical sleep, enhances energy conservation, reduces limbic dopamine, and increases depressive behavior. This review describes these different effects of the neuropeptides, developing the hypothesis that they stimulate the consumption of palatable food through excessive seeking in the case of OX and through excessive energy conservation in the case of MCH. It proposes that OX initiates food intake and subsequently stimulates MCH which then acts to prolong the consumption of palatable, energy-dense food. |
| format | Article |
| id | doaj-art-db984e15c48543b896ac7cbf4542fab1 |
| institution | Kabale University |
| issn | 1687-8337 1687-8345 |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
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| series | International Journal of Endocrinology |
| spelling | doaj-art-db984e15c48543b896ac7cbf4542fab12025-08-20T03:24:21ZengWileyInternational Journal of Endocrinology1687-83371687-83452013-01-01201310.1155/2013/983964983964Complementary Roles of Orexin and Melanin-Concentrating Hormone in Feeding BehaviorJessica R. Barson0Irene Morganstern1Sarah F. Leibowitz2Laboratory of Behavioral Neurobiology, The Rockefeller University, 1230 York Avenue, New York, NY 10065, USALaboratory of Behavioral Neurobiology, The Rockefeller University, 1230 York Avenue, New York, NY 10065, USALaboratory of Behavioral Neurobiology, The Rockefeller University, 1230 York Avenue, New York, NY 10065, USATranscribed within the lateral hypothalamus, the neuropeptides orexin/hypocretin (OX) and melanin-concentrating hormone (MCH) both promote palatable food intake and are stimulated by palatable food. While these two neuropeptides share this similar positive relationship with food, recent evidence suggests that this occurs through different albeit complementary effects on behavior, with OX promoting food seeking and motivation for palatable food and MCH functioning during ongoing food intake, reinforcing the consumption of calorically dense foods. Further differences are evident in their effects on physiological processes, which are largely opposite in nature. For example, activation of OX receptors, which is neuronally excitatory, promotes waking, increases energy expenditure, and enhances limbic dopamine levels and reward. In contrast, activation of MCH receptors, which is neuronally inhibitory, promotes paradoxical sleep, enhances energy conservation, reduces limbic dopamine, and increases depressive behavior. This review describes these different effects of the neuropeptides, developing the hypothesis that they stimulate the consumption of palatable food through excessive seeking in the case of OX and through excessive energy conservation in the case of MCH. It proposes that OX initiates food intake and subsequently stimulates MCH which then acts to prolong the consumption of palatable, energy-dense food.http://dx.doi.org/10.1155/2013/983964 |
| spellingShingle | Jessica R. Barson Irene Morganstern Sarah F. Leibowitz Complementary Roles of Orexin and Melanin-Concentrating Hormone in Feeding Behavior International Journal of Endocrinology |
| title | Complementary Roles of Orexin and Melanin-Concentrating Hormone in Feeding Behavior |
| title_full | Complementary Roles of Orexin and Melanin-Concentrating Hormone in Feeding Behavior |
| title_fullStr | Complementary Roles of Orexin and Melanin-Concentrating Hormone in Feeding Behavior |
| title_full_unstemmed | Complementary Roles of Orexin and Melanin-Concentrating Hormone in Feeding Behavior |
| title_short | Complementary Roles of Orexin and Melanin-Concentrating Hormone in Feeding Behavior |
| title_sort | complementary roles of orexin and melanin concentrating hormone in feeding behavior |
| url | http://dx.doi.org/10.1155/2013/983964 |
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