Docosahexaenoic Acid Inhibits Osteoclastogenesis via FFAR4-Mediated Regulation of Inflammatory Cytokines

Docosahexaenoic Acid Inhibits Osteoclastogenesis via FFAR4-Mediated Regulation of Inflammatory Cytokines

Osteoclastogenesis—the activation and differentiation of osteoclasts—is one of the pivotal processes of bone remodeling and is regulated by RANKL/RANK signaling, the decoy function of osteoprotegerin (OPG), and a cascade of pro- and anti-inflammatory cytokines. The disruption of this balance leads t...

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Bibliographic Details
Main Authors: Jinghan Ma, Hideki Kitaura, Fumitoshi Ohori, Aseel Marahleh, Ziqiu Fan, Angyi Lin, Kohei Narita, Kou Murakami, Hiroyasu Kanetaka
Format: Article
Language:English
Published: MDPI AG 2025-07-01
Series:Molecules
Subjects:
docosahexaenoic acid
FFAR4
osteoclast
bone metabolism
Online Access:https://www.mdpi.com/1420-3049/30/15/3180
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