Peroxisome Proliferator-Activated Receptor-γ Is Critical to Cardiac Fibrosis
Peroxisome proliferator-activated receptor-γ (PPARγ) is a ligand-activated transcription factor belonging to the nuclear receptor superfamily, which plays a central role in regulating lipid and glucose metabolism. However, accumulating evidence demonstrates that PPARγ agonists have potential to redu...
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| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2016-01-01
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| Series: | PPAR Research |
| Online Access: | http://dx.doi.org/10.1155/2016/2198645 |
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| _version_ | 1849472935104872448 |
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| author | Huang-Jun Liu Hai-Han Liao Zheng Yang Qi-Zhu Tang |
| author_facet | Huang-Jun Liu Hai-Han Liao Zheng Yang Qi-Zhu Tang |
| author_sort | Huang-Jun Liu |
| collection | DOAJ |
| description | Peroxisome proliferator-activated receptor-γ (PPARγ) is a ligand-activated transcription factor belonging to the nuclear receptor superfamily, which plays a central role in regulating lipid and glucose metabolism. However, accumulating evidence demonstrates that PPARγ agonists have potential to reduce inflammation, influence the balance of immune cells, suppress oxidative stress, and improve endothelial function, which are all involved in the cellular and molecular mechanisms of cardiac fibrosis. Thus, in this review we discuss the role of PPARγ in various cardiovascular conditions associated with cardiac fibrosis, including diabetes mellitus, hypertension, myocardial infarction, heart failure, ischemia/reperfusion injury, atrial fibrillation, and several other cardiovascular disease (CVD) conditions, and summarize the developmental status of PPARγ agonists for the clinical management of CVD. |
| format | Article |
| id | doaj-art-db9219d18ea642acb40ea3f2592847de |
| institution | Kabale University |
| issn | 1687-4757 1687-4765 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | PPAR Research |
| spelling | doaj-art-db9219d18ea642acb40ea3f2592847de2025-08-20T03:24:21ZengWileyPPAR Research1687-47571687-47652016-01-01201610.1155/2016/21986452198645Peroxisome Proliferator-Activated Receptor-γ Is Critical to Cardiac FibrosisHuang-Jun Liu0Hai-Han Liao1Zheng Yang2Qi-Zhu Tang3Department of Cardiology, Renmin Hospital of Wuhan University, Wuhan 430060, ChinaDepartment of Cardiology, Renmin Hospital of Wuhan University, Wuhan 430060, ChinaDepartment of Cardiology, Renmin Hospital of Wuhan University, Wuhan 430060, ChinaDepartment of Cardiology, Renmin Hospital of Wuhan University, Wuhan 430060, ChinaPeroxisome proliferator-activated receptor-γ (PPARγ) is a ligand-activated transcription factor belonging to the nuclear receptor superfamily, which plays a central role in regulating lipid and glucose metabolism. However, accumulating evidence demonstrates that PPARγ agonists have potential to reduce inflammation, influence the balance of immune cells, suppress oxidative stress, and improve endothelial function, which are all involved in the cellular and molecular mechanisms of cardiac fibrosis. Thus, in this review we discuss the role of PPARγ in various cardiovascular conditions associated with cardiac fibrosis, including diabetes mellitus, hypertension, myocardial infarction, heart failure, ischemia/reperfusion injury, atrial fibrillation, and several other cardiovascular disease (CVD) conditions, and summarize the developmental status of PPARγ agonists for the clinical management of CVD.http://dx.doi.org/10.1155/2016/2198645 |
| spellingShingle | Huang-Jun Liu Hai-Han Liao Zheng Yang Qi-Zhu Tang Peroxisome Proliferator-Activated Receptor-γ Is Critical to Cardiac Fibrosis PPAR Research |
| title | Peroxisome Proliferator-Activated Receptor-γ Is Critical to Cardiac Fibrosis |
| title_full | Peroxisome Proliferator-Activated Receptor-γ Is Critical to Cardiac Fibrosis |
| title_fullStr | Peroxisome Proliferator-Activated Receptor-γ Is Critical to Cardiac Fibrosis |
| title_full_unstemmed | Peroxisome Proliferator-Activated Receptor-γ Is Critical to Cardiac Fibrosis |
| title_short | Peroxisome Proliferator-Activated Receptor-γ Is Critical to Cardiac Fibrosis |
| title_sort | peroxisome proliferator activated receptor γ is critical to cardiac fibrosis |
| url | http://dx.doi.org/10.1155/2016/2198645 |
| work_keys_str_mv | AT huangjunliu peroxisomeproliferatoractivatedreceptorgiscriticaltocardiacfibrosis AT haihanliao peroxisomeproliferatoractivatedreceptorgiscriticaltocardiacfibrosis AT zhengyang peroxisomeproliferatoractivatedreceptorgiscriticaltocardiacfibrosis AT qizhutang peroxisomeproliferatoractivatedreceptorgiscriticaltocardiacfibrosis |