CLINICAL STUDIES OF THE VACCINE PREPARATION FOR PREVENTION OF FLEXNER DYSENTERY ON THE BASIS OF MODIFIED SHIGELLA FLEXNERI LIPOPOLYSACCHARIDE (BASED ON THE RESULTS OF THE I PHASE OF CLINICAL TRIALS)
The article presents the results of the I phase of clinical trials of a vaccine preparationfor prevention of Flexner dysentery on the basis of modified Shigella flexneri lipopolysaccharide on the limited contingent of adult volunteers (26 persons). Studying general and local post-inoculative reactio...
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| Format: | Article |
| Language: | Russian |
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Scientific Сentre for Family Health and Human Reproduction Problems
2014-07-01
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| Series: | Acta Biomedica Scientifica |
| Subjects: | |
| Online Access: | https://www.actabiomedica.ru/jour/article/view/1797 |
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| _version_ | 1849251609108807680 |
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| author | V. A. Lyodov P. G. Aparin |
| author_facet | V. A. Lyodov P. G. Aparin |
| author_sort | V. A. Lyodov |
| collection | DOAJ |
| description | The article presents the results of the I phase of clinical trials of a vaccine preparationfor prevention of Flexner dysentery on the basis of modified Shigella flexneri lipopolysaccharide on the limited contingent of adult volunteers (26 persons). Studying general and local post-inoculative reactions showed good acceptability and low reactogenicity of candidate vaccine "FLEXVAC®" in the doses from 25 to 100 gg. In the majority ofvolunteers immunized by the candidate vaccine "FLEXVAC®" we registered 4 and more times seroconversion of IgG and IgA classes antibodies playing basic role in the formation of adaptive anti-shigella immune response. |
| format | Article |
| id | doaj-art-db91a2dac1da4b1db35df80eb65dcba7 |
| institution | Kabale University |
| issn | 2541-9420 2587-9596 |
| language | Russian |
| publishDate | 2014-07-01 |
| publisher | Scientific Сentre for Family Health and Human Reproduction Problems |
| record_format | Article |
| series | Acta Biomedica Scientifica |
| spelling | doaj-art-db91a2dac1da4b1db35df80eb65dcba72025-08-20T03:56:54ZrusScientific Сentre for Family Health and Human Reproduction ProblemsActa Biomedica Scientifica2541-94202587-95962014-07-010491951743CLINICAL STUDIES OF THE VACCINE PREPARATION FOR PREVENTION OF FLEXNER DYSENTERY ON THE BASIS OF MODIFIED SHIGELLA FLEXNERI LIPOPOLYSACCHARIDE (BASED ON THE RESULTS OF THE I PHASE OF CLINICAL TRIALS)V. A. Lyodov0P. G. Aparin1National Research Center “Institute of Immunology” of Federal Medical-Biological Agency of RussiaNational Research Center “Institute of Immunology” of Federal Medical-Biological Agency of RussiaThe article presents the results of the I phase of clinical trials of a vaccine preparationfor prevention of Flexner dysentery on the basis of modified Shigella flexneri lipopolysaccharide on the limited contingent of adult volunteers (26 persons). Studying general and local post-inoculative reactions showed good acceptability and low reactogenicity of candidate vaccine "FLEXVAC®" in the doses from 25 to 100 gg. In the majority ofvolunteers immunized by the candidate vaccine "FLEXVAC®" we registered 4 and more times seroconversion of IgG and IgA classes antibodies playing basic role in the formation of adaptive anti-shigella immune response.https://www.actabiomedica.ru/jour/article/view/1797shigella flexneri 2аflexner dysenteryshigella flexneri 2ashigellosiss. flexneri 2a vaccines |
| spellingShingle | V. A. Lyodov P. G. Aparin CLINICAL STUDIES OF THE VACCINE PREPARATION FOR PREVENTION OF FLEXNER DYSENTERY ON THE BASIS OF MODIFIED SHIGELLA FLEXNERI LIPOPOLYSACCHARIDE (BASED ON THE RESULTS OF THE I PHASE OF CLINICAL TRIALS) Acta Biomedica Scientifica shigella flexneri 2а flexner dysentery shigella flexneri 2a shigellosis s. flexneri 2a vaccines |
| title | CLINICAL STUDIES OF THE VACCINE PREPARATION FOR PREVENTION OF FLEXNER DYSENTERY ON THE BASIS OF MODIFIED SHIGELLA FLEXNERI LIPOPOLYSACCHARIDE (BASED ON THE RESULTS OF THE I PHASE OF CLINICAL TRIALS) |
| title_full | CLINICAL STUDIES OF THE VACCINE PREPARATION FOR PREVENTION OF FLEXNER DYSENTERY ON THE BASIS OF MODIFIED SHIGELLA FLEXNERI LIPOPOLYSACCHARIDE (BASED ON THE RESULTS OF THE I PHASE OF CLINICAL TRIALS) |
| title_fullStr | CLINICAL STUDIES OF THE VACCINE PREPARATION FOR PREVENTION OF FLEXNER DYSENTERY ON THE BASIS OF MODIFIED SHIGELLA FLEXNERI LIPOPOLYSACCHARIDE (BASED ON THE RESULTS OF THE I PHASE OF CLINICAL TRIALS) |
| title_full_unstemmed | CLINICAL STUDIES OF THE VACCINE PREPARATION FOR PREVENTION OF FLEXNER DYSENTERY ON THE BASIS OF MODIFIED SHIGELLA FLEXNERI LIPOPOLYSACCHARIDE (BASED ON THE RESULTS OF THE I PHASE OF CLINICAL TRIALS) |
| title_short | CLINICAL STUDIES OF THE VACCINE PREPARATION FOR PREVENTION OF FLEXNER DYSENTERY ON THE BASIS OF MODIFIED SHIGELLA FLEXNERI LIPOPOLYSACCHARIDE (BASED ON THE RESULTS OF THE I PHASE OF CLINICAL TRIALS) |
| title_sort | clinical studies of the vaccine preparation for prevention of flexner dysentery on the basis of modified shigella flexneri lipopolysaccharide based on the results of the i phase of clinical trials |
| topic | shigella flexneri 2а flexner dysentery shigella flexneri 2a shigellosis s. flexneri 2a vaccines |
| url | https://www.actabiomedica.ru/jour/article/view/1797 |
| work_keys_str_mv | AT valyodov clinicalstudiesofthevaccinepreparationforpreventionofflexnerdysenteryonthebasisofmodifiedshigellaflexnerilipopolysaccharidebasedontheresultsoftheiphaseofclinicaltrials AT pgaparin clinicalstudiesofthevaccinepreparationforpreventionofflexnerdysenteryonthebasisofmodifiedshigellaflexnerilipopolysaccharidebasedontheresultsoftheiphaseofclinicaltrials |