Progress on mitochondria and hair follicle development in androgenetic alopecia: relationships and therapeutic perspectives
Abstract Hair loss has long been a significant concern for many individuals. Recent studies have indicated that mitochondria play a more crucial role in hair loss than previously recognized. This review summarizes the connection between mitochondrial dysfunction and hair follicle development, outlin...
Saved in:
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2025-02-01
|
| Series: | Stem Cell Research & Therapy |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s13287-025-04182-z |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1825197683560677376 |
|---|---|
| author | Ting-ru Dong Yu-jie Li Shi-yu Jin Feng-lan Yang Ren-xue Xiong Ye-qin Dai Xiu-zu Song Cui-ping Guan |
| author_facet | Ting-ru Dong Yu-jie Li Shi-yu Jin Feng-lan Yang Ren-xue Xiong Ye-qin Dai Xiu-zu Song Cui-ping Guan |
| author_sort | Ting-ru Dong |
| collection | DOAJ |
| description | Abstract Hair loss has long been a significant concern for many individuals. Recent studies have indicated that mitochondria play a more crucial role in hair loss than previously recognized. This review summarizes the connection between mitochondrial dysfunction and hair follicle development, outlines the links between diseases related to mitochondrial disorders and hair issues, and highlights the influence of mitochondrial dysfunction on androgenetic alopecia. We discuss the cellular and signaling mechanisms associated with hair loss and examine how mitochondrial dysfunction, such as insufficient energy supply, signaling irregularities, protein/gene abnormalities, and programmed cell death, can hinder the normal proliferation, differentiation, and growth of hair follicle cells. Furthermore, we discuss current treatment approaches and potential innovative therapies, including mitochondrion-targeting drugs and advanced techniques that directly target hair follicle cells, providing fresh insights into the crucial role of mitochondria in maintaining hair follicle health and managing hair disorders. Furthermore, this review explores future therapeutic strategies and proposes that mitochondrial research could lead to groundbreaking treatments for hair loss, thus providing optimism and new avenues for the treatment of individuals experiencing hair loss. This review not only underscores the central importance of mitochondria in hair health but also emphasizes the importance of advancing research and treatment in this field. Graphical abstract |
| format | Article |
| id | doaj-art-db90e3ed1f544caf96c6c77a15c41164 |
| institution | Kabale University |
| issn | 1757-6512 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | BMC |
| record_format | Article |
| series | Stem Cell Research & Therapy |
| spelling | doaj-art-db90e3ed1f544caf96c6c77a15c411642025-02-09T12:15:30ZengBMCStem Cell Research & Therapy1757-65122025-02-0116112110.1186/s13287-025-04182-zProgress on mitochondria and hair follicle development in androgenetic alopecia: relationships and therapeutic perspectivesTing-ru Dong0Yu-jie Li1Shi-yu Jin2Feng-lan Yang3Ren-xue Xiong4Ye-qin Dai5Xiu-zu Song6Cui-ping Guan7Department of Dermatology, Hangzhou Third Hospital Affiliated to Zhejiang Chinese Medical UniversityDepartment of Dermatology, Hangzhou Third Hospital Affiliated to Zhejiang Chinese Medical UniversityDepartment of Dermatology, Hangzhou Third Hospital Affiliated to Zhejiang Chinese Medical UniversityDepartment of Dermatology, Hangzhou Third Hospital Affiliated to Zhejiang Chinese Medical UniversityDepartment of Dermatology, Hangzhou Third Hospital Affiliated to Zhejiang Chinese Medical UniversityDepartment of Dermatology, Hangzhou Third Hospital Affiliated to Zhejiang Chinese Medical UniversityDepartment of Dermatology, Hangzhou Third Hospital Affiliated to Zhejiang Chinese Medical UniversityDepartment of Dermatology, Hangzhou Third Hospital Affiliated to Zhejiang Chinese Medical UniversityAbstract Hair loss has long been a significant concern for many individuals. Recent studies have indicated that mitochondria play a more crucial role in hair loss than previously recognized. This review summarizes the connection between mitochondrial dysfunction and hair follicle development, outlines the links between diseases related to mitochondrial disorders and hair issues, and highlights the influence of mitochondrial dysfunction on androgenetic alopecia. We discuss the cellular and signaling mechanisms associated with hair loss and examine how mitochondrial dysfunction, such as insufficient energy supply, signaling irregularities, protein/gene abnormalities, and programmed cell death, can hinder the normal proliferation, differentiation, and growth of hair follicle cells. Furthermore, we discuss current treatment approaches and potential innovative therapies, including mitochondrion-targeting drugs and advanced techniques that directly target hair follicle cells, providing fresh insights into the crucial role of mitochondria in maintaining hair follicle health and managing hair disorders. Furthermore, this review explores future therapeutic strategies and proposes that mitochondrial research could lead to groundbreaking treatments for hair loss, thus providing optimism and new avenues for the treatment of individuals experiencing hair loss. This review not only underscores the central importance of mitochondria in hair health but also emphasizes the importance of advancing research and treatment in this field. Graphical abstracthttps://doi.org/10.1186/s13287-025-04182-zMitochondriaHair follicleAndrogenetic alopecia |
| spellingShingle | Ting-ru Dong Yu-jie Li Shi-yu Jin Feng-lan Yang Ren-xue Xiong Ye-qin Dai Xiu-zu Song Cui-ping Guan Progress on mitochondria and hair follicle development in androgenetic alopecia: relationships and therapeutic perspectives Stem Cell Research & Therapy Mitochondria Hair follicle Androgenetic alopecia |
| title | Progress on mitochondria and hair follicle development in androgenetic alopecia: relationships and therapeutic perspectives |
| title_full | Progress on mitochondria and hair follicle development in androgenetic alopecia: relationships and therapeutic perspectives |
| title_fullStr | Progress on mitochondria and hair follicle development in androgenetic alopecia: relationships and therapeutic perspectives |
| title_full_unstemmed | Progress on mitochondria and hair follicle development in androgenetic alopecia: relationships and therapeutic perspectives |
| title_short | Progress on mitochondria and hair follicle development in androgenetic alopecia: relationships and therapeutic perspectives |
| title_sort | progress on mitochondria and hair follicle development in androgenetic alopecia relationships and therapeutic perspectives |
| topic | Mitochondria Hair follicle Androgenetic alopecia |
| url | https://doi.org/10.1186/s13287-025-04182-z |
| work_keys_str_mv | AT tingrudong progressonmitochondriaandhairfollicledevelopmentinandrogeneticalopeciarelationshipsandtherapeuticperspectives AT yujieli progressonmitochondriaandhairfollicledevelopmentinandrogeneticalopeciarelationshipsandtherapeuticperspectives AT shiyujin progressonmitochondriaandhairfollicledevelopmentinandrogeneticalopeciarelationshipsandtherapeuticperspectives AT fenglanyang progressonmitochondriaandhairfollicledevelopmentinandrogeneticalopeciarelationshipsandtherapeuticperspectives AT renxuexiong progressonmitochondriaandhairfollicledevelopmentinandrogeneticalopeciarelationshipsandtherapeuticperspectives AT yeqindai progressonmitochondriaandhairfollicledevelopmentinandrogeneticalopeciarelationshipsandtherapeuticperspectives AT xiuzusong progressonmitochondriaandhairfollicledevelopmentinandrogeneticalopeciarelationshipsandtherapeuticperspectives AT cuipingguan progressonmitochondriaandhairfollicledevelopmentinandrogeneticalopeciarelationshipsandtherapeuticperspectives |