Tissue engineering strategies for treating intervertebral disc degeneration
Low back pain (LBP) is becoming prevalent in clinics, owing primarily to intervertebral disc degeneration (IDD). The mechanism of IDD is complex, and its pathophysiology is primarily characterized by a decrease in intervertebral nucleus pulposus cells and an imbalance in the synthesis and degradatio...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2025-07-01
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| Series: | Frontiers in Bioengineering and Biotechnology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fbioe.2025.1582189/full |
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| author | Guangshuai Nie Guangshuai Nie Weiyang Liu Weiyang Liu Fanjia Zeng Fanjia Zeng Jia Hu Jia Hu Zhen Wang Zhen Wang Zhonglian Huang Zhonglian Huang Hongjiang Chen Hongjiang Chen Jun Hu Jun Hu Jiankun Xu Jiankun Xu |
| author_facet | Guangshuai Nie Guangshuai Nie Weiyang Liu Weiyang Liu Fanjia Zeng Fanjia Zeng Jia Hu Jia Hu Zhen Wang Zhen Wang Zhonglian Huang Zhonglian Huang Hongjiang Chen Hongjiang Chen Jun Hu Jun Hu Jiankun Xu Jiankun Xu |
| author_sort | Guangshuai Nie |
| collection | DOAJ |
| description | Low back pain (LBP) is becoming prevalent in clinics, owing primarily to intervertebral disc degeneration (IDD). The mechanism of IDD is complex, and its pathophysiology is primarily characterized by a decrease in intervertebral nucleus pulposus cells and an imbalance in the synthesis and degradation of the extracellular matrix of the intervertebral disc (IVD). Grounded in the concept of regenerative repair, IVD engineering has emerged as a significant research focus in spinal surgery. This review systematically examines the relationship between LBP and IDD, describes the physiological characteristics of healthy IVD and the pathological features of IDD (including inflammatory responses and stress stimulation), and provides an overview of current treatment methods and clinical trials. The review focuses on summarizing and evaluating tissue engineering research, particularly the preclinical and clinical findings on the effects of various seed cells, bio-scaffolds, and bioactive factors on IVD, to explore a more comprehensive therapeutic approach. Lastly, the obstacles and opportunities of tissue engineering repair of the IVD are highlighted. |
| format | Article |
| id | doaj-art-db8f7d32988d439fbe74d249211cccba |
| institution | Kabale University |
| issn | 2296-4185 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Bioengineering and Biotechnology |
| spelling | doaj-art-db8f7d32988d439fbe74d249211cccba2025-08-20T03:49:56ZengFrontiers Media S.A.Frontiers in Bioengineering and Biotechnology2296-41852025-07-011310.3389/fbioe.2025.15821891582189Tissue engineering strategies for treating intervertebral disc degenerationGuangshuai Nie0Guangshuai Nie1Weiyang Liu2Weiyang Liu3Fanjia Zeng4Fanjia Zeng5Jia Hu6Jia Hu7Zhen Wang8Zhen Wang9Zhonglian Huang10Zhonglian Huang11Hongjiang Chen12Hongjiang Chen13Jun Hu14Jun Hu15Jiankun Xu16Jiankun Xu17Department of Orthopaedics, The First Affiliated Hospital of Shantou University Medical College, Shantou, Guangdong, ChinaOrthopaedic Medical Research Center, The First Affiliated Hospital, Shantou University Medical College, Shantou, Guangdong, ChinaDepartment of Orthopaedics, The First Affiliated Hospital of Shantou University Medical College, Shantou, Guangdong, ChinaOrthopaedic Medical Research Center, The First Affiliated Hospital, Shantou University Medical College, Shantou, Guangdong, ChinaDepartment of Orthopaedics, The First Affiliated Hospital of Shantou University Medical College, Shantou, Guangdong, ChinaOrthopaedic Medical Research Center, The First Affiliated Hospital, Shantou University Medical College, Shantou, Guangdong, ChinaDepartment of Orthopaedics, The First Affiliated Hospital of Shantou University Medical College, Shantou, Guangdong, ChinaOrthopaedic Medical Research Center, The First Affiliated Hospital, Shantou University Medical College, Shantou, Guangdong, ChinaDepartment of Orthopaedics, The First Affiliated Hospital of Shantou University Medical College, Shantou, Guangdong, ChinaOrthopaedic Medical Research Center, The First Affiliated Hospital, Shantou University Medical College, Shantou, Guangdong, ChinaDepartment of Orthopaedics, The First Affiliated Hospital of Shantou University Medical College, Shantou, Guangdong, ChinaOrthopaedic Medical Research Center, The First Affiliated Hospital, Shantou University Medical College, Shantou, Guangdong, ChinaDepartment of Orthopaedics, The First Affiliated Hospital of Shantou University Medical College, Shantou, Guangdong, ChinaOrthopaedic Medical Research Center, The First Affiliated Hospital, Shantou University Medical College, Shantou, Guangdong, ChinaDepartment of Orthopaedics, The First Affiliated Hospital of Shantou University Medical College, Shantou, Guangdong, ChinaOrthopaedic Medical Research Center, The First Affiliated Hospital, Shantou University Medical College, Shantou, Guangdong, ChinaMusculoskeletal Research Laboratory of Department of Orthopaedics and Traumatology and Innovative Orthopaedic Biomaterial and Drug Translational Research Laboratory, Li Ka Shing Institute of Health, the Chinese University of Hong Kong, Sha Tin, Hong Kong SAR, ChinaDisruptive Innovation Centre for Spatiotemporal Imaging, Li Ka Shing Institute of Health Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, Hong Kong SAR, ChinaLow back pain (LBP) is becoming prevalent in clinics, owing primarily to intervertebral disc degeneration (IDD). The mechanism of IDD is complex, and its pathophysiology is primarily characterized by a decrease in intervertebral nucleus pulposus cells and an imbalance in the synthesis and degradation of the extracellular matrix of the intervertebral disc (IVD). Grounded in the concept of regenerative repair, IVD engineering has emerged as a significant research focus in spinal surgery. This review systematically examines the relationship between LBP and IDD, describes the physiological characteristics of healthy IVD and the pathological features of IDD (including inflammatory responses and stress stimulation), and provides an overview of current treatment methods and clinical trials. The review focuses on summarizing and evaluating tissue engineering research, particularly the preclinical and clinical findings on the effects of various seed cells, bio-scaffolds, and bioactive factors on IVD, to explore a more comprehensive therapeutic approach. Lastly, the obstacles and opportunities of tissue engineering repair of the IVD are highlighted.https://www.frontiersin.org/articles/10.3389/fbioe.2025.1582189/fulllow back painintervertebral discintervertebral disc degenerationstem cellscell carriersbiological scaffolds |
| spellingShingle | Guangshuai Nie Guangshuai Nie Weiyang Liu Weiyang Liu Fanjia Zeng Fanjia Zeng Jia Hu Jia Hu Zhen Wang Zhen Wang Zhonglian Huang Zhonglian Huang Hongjiang Chen Hongjiang Chen Jun Hu Jun Hu Jiankun Xu Jiankun Xu Tissue engineering strategies for treating intervertebral disc degeneration Frontiers in Bioengineering and Biotechnology low back pain intervertebral disc intervertebral disc degeneration stem cells cell carriers biological scaffolds |
| title | Tissue engineering strategies for treating intervertebral disc degeneration |
| title_full | Tissue engineering strategies for treating intervertebral disc degeneration |
| title_fullStr | Tissue engineering strategies for treating intervertebral disc degeneration |
| title_full_unstemmed | Tissue engineering strategies for treating intervertebral disc degeneration |
| title_short | Tissue engineering strategies for treating intervertebral disc degeneration |
| title_sort | tissue engineering strategies for treating intervertebral disc degeneration |
| topic | low back pain intervertebral disc intervertebral disc degeneration stem cells cell carriers biological scaffolds |
| url | https://www.frontiersin.org/articles/10.3389/fbioe.2025.1582189/full |
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