A systematic analysis and prediction of the disease burden of ischemic heart disease caused by hyperglycemia
ABSTRACT Objective This study aims to analyze the disease burden of ischemic heart disease (IHD) caused by hyperglycemia and its changing trend, and to construct a visualization platform for disease burden and forecast trends on the Shiny platform. Materials and Methods Using data from the 2021 Glob...
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| Format: | Article |
| Language: | English |
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Wiley
2025-06-01
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| Series: | Journal of Diabetes Investigation |
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| Online Access: | https://doi.org/10.1111/jdi.70006 |
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| author | Jianxing Chen Wenlinng Zeng Dandan Dai Yujin Tang Yangwen Dong Zilan Zhong Miao Zhou Jianhong Ye |
| author_facet | Jianxing Chen Wenlinng Zeng Dandan Dai Yujin Tang Yangwen Dong Zilan Zhong Miao Zhou Jianhong Ye |
| author_sort | Jianxing Chen |
| collection | DOAJ |
| description | ABSTRACT Objective This study aims to analyze the disease burden of ischemic heart disease (IHD) caused by hyperglycemia and its changing trend, and to construct a visualization platform for disease burden and forecast trends on the Shiny platform. Materials and Methods Using data from the 2021 Global Burden of Disease Study, we analyzed deaths and disability‐adjusted life years (DALYs) due to IHD triggered by hyperglycemia, with detailed analysis by region, gender, and age. The age‐period‐cohort model was used to assess the impact of age, cohort, and period on age‐standardized disease rates across different Socio‐Demographic Index (SDI) regions, and decomposition analysis was employed to disentangle the contributions of population, aging, and epidemiological changes. Results In 2021, approximately 14–15% of IHD's DALYs and deaths were attributed to high fasting plasma glucose (HFPG), with a nonsignificant decrease in the annual average percentage change of DALYs. In middle, low‐middle, and low SDI regions, the age‐standardized mortality rates caused by HFPG are increasing, particularly among males. In high‐middle and high SDI regions, the effects of aging and epidemiological changes surpass population growth, whereas in low SDI regions, population growth is the main factor. By 2050, the global Age‐Standardized Mortality Rate of IHD attributed to HFPG is projected to reach 16.96. More data can be accessed by visiting the disease burden visualization platform. Conclusion Global HFPG‐induced IHD health presents significant imbalances. In low SDI regions with larger populations and more unbalanced healthcare distribution, there is a need to strengthen the construction of medical levels. |
| format | Article |
| id | doaj-art-db8ee2b67a4645b4a6dc770a66c542b1 |
| institution | DOAJ |
| issn | 2040-1116 2040-1124 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Diabetes Investigation |
| spelling | doaj-art-db8ee2b67a4645b4a6dc770a66c542b12025-08-20T03:19:24ZengWileyJournal of Diabetes Investigation2040-11162040-11242025-06-011661065108010.1111/jdi.70006A systematic analysis and prediction of the disease burden of ischemic heart disease caused by hyperglycemiaJianxing Chen0Wenlinng Zeng1Dandan Dai2Yujin Tang3Yangwen Dong4Zilan Zhong5Miao Zhou6Jianhong Ye7Dongguan Hospital of Guangzhou University of Traditional Chinese Medicine Dongguan ChinaNanchang University Nanchang ChinaGuangzhou University of Chinese Medicine Guangzhou ChinaEighth Clinical School Guangzhou University of Chinese Medicine Foshan Guangdong ChinaGuangzhou University of Chinese Medicine Guangzhou ChinaGuangzhou University of Chinese Medicine Guangzhou ChinaFoshan Hospital of Traditional Chinese Medicine Foshan ChinaFoshan Hospital of Traditional Chinese Medicine Foshan ChinaABSTRACT Objective This study aims to analyze the disease burden of ischemic heart disease (IHD) caused by hyperglycemia and its changing trend, and to construct a visualization platform for disease burden and forecast trends on the Shiny platform. Materials and Methods Using data from the 2021 Global Burden of Disease Study, we analyzed deaths and disability‐adjusted life years (DALYs) due to IHD triggered by hyperglycemia, with detailed analysis by region, gender, and age. The age‐period‐cohort model was used to assess the impact of age, cohort, and period on age‐standardized disease rates across different Socio‐Demographic Index (SDI) regions, and decomposition analysis was employed to disentangle the contributions of population, aging, and epidemiological changes. Results In 2021, approximately 14–15% of IHD's DALYs and deaths were attributed to high fasting plasma glucose (HFPG), with a nonsignificant decrease in the annual average percentage change of DALYs. In middle, low‐middle, and low SDI regions, the age‐standardized mortality rates caused by HFPG are increasing, particularly among males. In high‐middle and high SDI regions, the effects of aging and epidemiological changes surpass population growth, whereas in low SDI regions, population growth is the main factor. By 2050, the global Age‐Standardized Mortality Rate of IHD attributed to HFPG is projected to reach 16.96. More data can be accessed by visiting the disease burden visualization platform. Conclusion Global HFPG‐induced IHD health presents significant imbalances. In low SDI regions with larger populations and more unbalanced healthcare distribution, there is a need to strengthen the construction of medical levels.https://doi.org/10.1111/jdi.70006Disease burdenHyperglycemiaIschemic heart disease |
| spellingShingle | Jianxing Chen Wenlinng Zeng Dandan Dai Yujin Tang Yangwen Dong Zilan Zhong Miao Zhou Jianhong Ye A systematic analysis and prediction of the disease burden of ischemic heart disease caused by hyperglycemia Journal of Diabetes Investigation Disease burden Hyperglycemia Ischemic heart disease |
| title | A systematic analysis and prediction of the disease burden of ischemic heart disease caused by hyperglycemia |
| title_full | A systematic analysis and prediction of the disease burden of ischemic heart disease caused by hyperglycemia |
| title_fullStr | A systematic analysis and prediction of the disease burden of ischemic heart disease caused by hyperglycemia |
| title_full_unstemmed | A systematic analysis and prediction of the disease burden of ischemic heart disease caused by hyperglycemia |
| title_short | A systematic analysis and prediction of the disease burden of ischemic heart disease caused by hyperglycemia |
| title_sort | systematic analysis and prediction of the disease burden of ischemic heart disease caused by hyperglycemia |
| topic | Disease burden Hyperglycemia Ischemic heart disease |
| url | https://doi.org/10.1111/jdi.70006 |
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