Alterations in Serum Adropin, Adiponectin, and Proinflammatory Cytokine Levels in OSAS
Objective. The present study was planned to examine the relationships between obstructive sleep apnea syndrome (OSAS) and the newly revealed adipokines adropin and adiponectin concentrations that display significant metabolic and cardiovascular functions and the levels of proinflammatory cytokine le...
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| Format: | Article |
| Language: | English |
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Wiley
2020-01-01
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| Series: | Canadian Respiratory Journal |
| Online Access: | http://dx.doi.org/10.1155/2020/2571283 |
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| _version_ | 1832568178271584256 |
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| author | Hakan Celikhisar Gulay Dasdemir Ilkhan |
| author_facet | Hakan Celikhisar Gulay Dasdemir Ilkhan |
| author_sort | Hakan Celikhisar |
| collection | DOAJ |
| description | Objective. The present study was planned to examine the relationships between obstructive sleep apnea syndrome (OSAS) and the newly revealed adipokines adropin and adiponectin concentrations that display significant metabolic and cardiovascular functions and the levels of proinflammatory cytokine levels. Method. A total of 166 overweight and obese male patients with a body mass index (BMI) >27 kg/m2 were included in the study. Among study participants, 84 were recently diagnosed with OSAS by polysomnography with an apnea-hypopnea index (AHI) ≥5, and 82 were nonapneic with normal polysomnography (AHI<5) findings. The serum adropin and adiponectin levels of all cases were analyzed via the enzyme-linked immunosorbent assay method. Serum interleukin-1 (IL-1) beta and tumor necrotizing factor-alpha (TNF-alpha) levels were determined using Luminex cytokine multiplex analyses. Results. The mean age of the OSAS patients was 50.9 ± 5.7 years and BMI was 32.4 ± 6.0 kg/m2, and there was no statistically significant difference determined with the control group (49.3 ± 5.8 years and 30.6 ± 5, 6 kg/m2) (p>0.05). There were no statistically significant differences between the OSAS and control groups concerning total cholesterol, triglyceride, low-density lipoprotein (LDL), high-density lipoprotein (HDL), and glucose levels. Adiponectin was lower in the OSAS group at a statistically significant level in comparison with the control group and was related at a statistically significant level to OSAS intensity. Adropin concentration was determined to be higher in the OSAS group at a statistically significant level in comparison with the control group. Conclusion. The results of our study suggest that increased adropin concentration may be an indicator of endothelium dysfunction in OSAS patients. Serum adropin and adiponectin levels may be new bioindicators used for diagnosis and risk assessment in OSAS patients. |
| format | Article |
| id | doaj-art-db8cdbcdcbf748199e1e6888e6641e80 |
| institution | Kabale University |
| issn | 1198-2241 1916-7245 |
| language | English |
| publishDate | 2020-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Canadian Respiratory Journal |
| spelling | doaj-art-db8cdbcdcbf748199e1e6888e6641e802025-02-03T00:59:41ZengWileyCanadian Respiratory Journal1198-22411916-72452020-01-01202010.1155/2020/25712832571283Alterations in Serum Adropin, Adiponectin, and Proinflammatory Cytokine Levels in OSASHakan Celikhisar0Gulay Dasdemir Ilkhan1Izmir Metropolitan Municipality Hospital, Chest Diseases Clinic, Gaziler Caddesi No. 315, 35110 Izmir, TurkeyOkmeydanı Training and Research Hospital, Chest Diseases Clinic, Kaptan Pasa Mahallesi, Darulaceze Cad. No. 25, 34384 Istanbul, TurkeyObjective. The present study was planned to examine the relationships between obstructive sleep apnea syndrome (OSAS) and the newly revealed adipokines adropin and adiponectin concentrations that display significant metabolic and cardiovascular functions and the levels of proinflammatory cytokine levels. Method. A total of 166 overweight and obese male patients with a body mass index (BMI) >27 kg/m2 were included in the study. Among study participants, 84 were recently diagnosed with OSAS by polysomnography with an apnea-hypopnea index (AHI) ≥5, and 82 were nonapneic with normal polysomnography (AHI<5) findings. The serum adropin and adiponectin levels of all cases were analyzed via the enzyme-linked immunosorbent assay method. Serum interleukin-1 (IL-1) beta and tumor necrotizing factor-alpha (TNF-alpha) levels were determined using Luminex cytokine multiplex analyses. Results. The mean age of the OSAS patients was 50.9 ± 5.7 years and BMI was 32.4 ± 6.0 kg/m2, and there was no statistically significant difference determined with the control group (49.3 ± 5.8 years and 30.6 ± 5, 6 kg/m2) (p>0.05). There were no statistically significant differences between the OSAS and control groups concerning total cholesterol, triglyceride, low-density lipoprotein (LDL), high-density lipoprotein (HDL), and glucose levels. Adiponectin was lower in the OSAS group at a statistically significant level in comparison with the control group and was related at a statistically significant level to OSAS intensity. Adropin concentration was determined to be higher in the OSAS group at a statistically significant level in comparison with the control group. Conclusion. The results of our study suggest that increased adropin concentration may be an indicator of endothelium dysfunction in OSAS patients. Serum adropin and adiponectin levels may be new bioindicators used for diagnosis and risk assessment in OSAS patients.http://dx.doi.org/10.1155/2020/2571283 |
| spellingShingle | Hakan Celikhisar Gulay Dasdemir Ilkhan Alterations in Serum Adropin, Adiponectin, and Proinflammatory Cytokine Levels in OSAS Canadian Respiratory Journal |
| title | Alterations in Serum Adropin, Adiponectin, and Proinflammatory Cytokine Levels in OSAS |
| title_full | Alterations in Serum Adropin, Adiponectin, and Proinflammatory Cytokine Levels in OSAS |
| title_fullStr | Alterations in Serum Adropin, Adiponectin, and Proinflammatory Cytokine Levels in OSAS |
| title_full_unstemmed | Alterations in Serum Adropin, Adiponectin, and Proinflammatory Cytokine Levels in OSAS |
| title_short | Alterations in Serum Adropin, Adiponectin, and Proinflammatory Cytokine Levels in OSAS |
| title_sort | alterations in serum adropin adiponectin and proinflammatory cytokine levels in osas |
| url | http://dx.doi.org/10.1155/2020/2571283 |
| work_keys_str_mv | AT hakancelikhisar alterationsinserumadropinadiponectinandproinflammatorycytokinelevelsinosas AT gulaydasdemirilkhan alterationsinserumadropinadiponectinandproinflammatorycytokinelevelsinosas |