Serum HDL and their subfractions are impaired in multisystem inflammatory syndrome in children (MIS-C)
Abstract Background Multisystem inflammatory syndrome in children (MIS-C) is a severe post-COVID condition due to a delayed hyperimmune response to SARS-CoV-2. High-density lipoproteins (HDL) are pivotal players in inflammatory and immune modulation through the remodeling of their subfractions. Meth...
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BMC
2025-01-01
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| Series: | Journal of Translational Medicine |
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| Online Access: | https://doi.org/10.1186/s12967-025-06123-z |
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| author | Antonietta Giannattasio Alice Castaldo Michela Grieco Monica Gelzo Gustavo Cernera Giuseppe Castaldo Vincenzo Tipo |
| author_facet | Antonietta Giannattasio Alice Castaldo Michela Grieco Monica Gelzo Gustavo Cernera Giuseppe Castaldo Vincenzo Tipo |
| author_sort | Antonietta Giannattasio |
| collection | DOAJ |
| description | Abstract Background Multisystem inflammatory syndrome in children (MIS-C) is a severe post-COVID condition due to a delayed hyperimmune response to SARS-CoV-2. High-density lipoproteins (HDL) are pivotal players in inflammatory and immune modulation through the remodeling of their subfractions. Methods This study aimed to evaluate serum levels of cholesterol, HDL, and HDL subfractions (HDL-SUB) to define their role in the pathogenesis of MIS-C and their potential use as biomarkers of this condition. We analyzed serum cholesterol, HDL and HDL-SUB (by capillary electrophoresis) in relation to serum values of biomarkers of inflammation and endothelial damage (by microfluidic immunoassays) in 48 patients with MIS-C at hospital admission and in 48 age- and sex-matched healthy controls. Results Serum cholesterol, as well as HDL, were significantly lower in MIS-C patients than controls. Serum cholesterol was inversely correlated with all biomarkers of inflammation, confirming the impact of cytokines on reverse cholesterol transport, whereas HDL values were inversely correlated with serum biomarkers of endothelial damage, suggesting a role of HDL in endothelial damage in MIS-C patients. Furthermore, we found a remodeling of HDL-SUB with a more pronounced decrease in small HDL that have anti-inflammatory activity. Conclusions These data confirm the severe impairment of reverse cholesterol transport in MIS-C and indicate serum HDL and HDL-SUB as potential useful diagnostic biomarkers of MIS-C. |
| format | Article |
| id | doaj-art-db86fa2331f8441eb40bc248096ac826 |
| institution | Kabale University |
| issn | 1479-5876 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Translational Medicine |
| spelling | doaj-art-db86fa2331f8441eb40bc248096ac8262025-01-26T12:50:17ZengBMCJournal of Translational Medicine1479-58762025-01-012311710.1186/s12967-025-06123-zSerum HDL and their subfractions are impaired in multisystem inflammatory syndrome in children (MIS-C)Antonietta Giannattasio0Alice Castaldo1Michela Grieco2Monica Gelzo3Gustavo Cernera4Giuseppe Castaldo5Vincenzo Tipo6Dipartimento di Pediatria Generale e d’Urgenza, AORN Santobono-PausiliponSC di Pneumologia e UTSIR, AORN Santobono-PausiliponDipartimento di Pediatria Generale e d’Urgenza, AORN Santobono-PausiliponDipartimento di Medicina Molecolare e Biotecnologie Mediche, Università di Napoli Federico IIDipartimento di Medicina Molecolare e Biotecnologie Mediche, Università di Napoli Federico IIDipartimento di Medicina Molecolare e Biotecnologie Mediche, Università di Napoli Federico IIDipartimento di Pediatria Generale e d’Urgenza, AORN Santobono-PausiliponAbstract Background Multisystem inflammatory syndrome in children (MIS-C) is a severe post-COVID condition due to a delayed hyperimmune response to SARS-CoV-2. High-density lipoproteins (HDL) are pivotal players in inflammatory and immune modulation through the remodeling of their subfractions. Methods This study aimed to evaluate serum levels of cholesterol, HDL, and HDL subfractions (HDL-SUB) to define their role in the pathogenesis of MIS-C and their potential use as biomarkers of this condition. We analyzed serum cholesterol, HDL and HDL-SUB (by capillary electrophoresis) in relation to serum values of biomarkers of inflammation and endothelial damage (by microfluidic immunoassays) in 48 patients with MIS-C at hospital admission and in 48 age- and sex-matched healthy controls. Results Serum cholesterol, as well as HDL, were significantly lower in MIS-C patients than controls. Serum cholesterol was inversely correlated with all biomarkers of inflammation, confirming the impact of cytokines on reverse cholesterol transport, whereas HDL values were inversely correlated with serum biomarkers of endothelial damage, suggesting a role of HDL in endothelial damage in MIS-C patients. Furthermore, we found a remodeling of HDL-SUB with a more pronounced decrease in small HDL that have anti-inflammatory activity. Conclusions These data confirm the severe impairment of reverse cholesterol transport in MIS-C and indicate serum HDL and HDL-SUB as potential useful diagnostic biomarkers of MIS-C.https://doi.org/10.1186/s12967-025-06123-zCholesterolSepsisInflammationBiomarkers |
| spellingShingle | Antonietta Giannattasio Alice Castaldo Michela Grieco Monica Gelzo Gustavo Cernera Giuseppe Castaldo Vincenzo Tipo Serum HDL and their subfractions are impaired in multisystem inflammatory syndrome in children (MIS-C) Journal of Translational Medicine Cholesterol Sepsis Inflammation Biomarkers |
| title | Serum HDL and their subfractions are impaired in multisystem inflammatory syndrome in children (MIS-C) |
| title_full | Serum HDL and their subfractions are impaired in multisystem inflammatory syndrome in children (MIS-C) |
| title_fullStr | Serum HDL and their subfractions are impaired in multisystem inflammatory syndrome in children (MIS-C) |
| title_full_unstemmed | Serum HDL and their subfractions are impaired in multisystem inflammatory syndrome in children (MIS-C) |
| title_short | Serum HDL and their subfractions are impaired in multisystem inflammatory syndrome in children (MIS-C) |
| title_sort | serum hdl and their subfractions are impaired in multisystem inflammatory syndrome in children mis c |
| topic | Cholesterol Sepsis Inflammation Biomarkers |
| url | https://doi.org/10.1186/s12967-025-06123-z |
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