Eradication of Helicobacter pylori: challenges and advances
Background and Objectives: Helicobacter pylori, identified in 1982, remains a major cause of gastric infections. Despite extensive research, an ideal treatment regimen for its eradication is yet to be determined, with antibiotic resistance posing a significant challenge. This study, conducted at Moh...
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| Format: | Article |
| Language: | English |
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Tehran University of Medical Sciences
2025-07-01
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| Series: | Iranian Journal of Microbiology |
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| Online Access: | https://ijm.tums.ac.ir/index.php/ijm/article/view/5155 |
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| author | Yousra Sbibih Abderrazak Saddari Ilham Alla Said Ezrari Elmostapha Benaissa Yassine Ben Lahlou Mostafa Elouennass Adil Maleb |
| author_facet | Yousra Sbibih Abderrazak Saddari Ilham Alla Said Ezrari Elmostapha Benaissa Yassine Ben Lahlou Mostafa Elouennass Adil Maleb |
| author_sort | Yousra Sbibih |
| collection | DOAJ |
| description | Background and Objectives: Helicobacter pylori, identified in 1982, remains a major cause of gastric infections. Despite extensive research, an ideal treatment regimen for its eradication is yet to be determined, with antibiotic resistance posing a significant challenge. This study, conducted at Mohammed VI University Hospital, aimed to evaluate and compare the effectiveness of different therapeutic protocols for H. pylori eradication.
Materials and Methods: This 13-month retrospective descriptive study was conducted at the Microbiology Laboratory of Mohammed VI University Hospital in Oujda, Morocco, to evaluate patients suspected of H. pylori infection using the urea breath test.
Results: A total of 190 patients were included, with an overall eradication rate of 73%. Three therapeutic protocols were tested, and bismuth concomitant therapy showed the highest eradication rate at 82%, outperforming the other regimens.
Conclusion: These findings highlight the importance of combining antimicrobial agents with antisecretory treatments to enhance eradication outcomes. The study also emphasizes the need for novel treatment strategies, particularly in light of rising antibiotic resistance. Vonoprazan-based regimens appear to offer a promising alternative, especially in the absence of antibiotic sensitivity testing. Future research should focus on optimizing treatment protocols while preserving beneficial gut flora.
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| format | Article |
| id | doaj-art-db866daa7a7349bda18d5359c997c0f5 |
| institution | DOAJ |
| issn | 2008-3289 2008-4447 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Tehran University of Medical Sciences |
| record_format | Article |
| series | Iranian Journal of Microbiology |
| spelling | doaj-art-db866daa7a7349bda18d5359c997c0f52025-08-20T03:03:04ZengTehran University of Medical SciencesIranian Journal of Microbiology2008-32892008-44472025-07-0117410.18502/ijm.v17i4.19248Eradication of Helicobacter pylori: challenges and advancesYousra Sbibih0Abderrazak Saddari1Ilham Alla2Said Ezrari3Elmostapha Benaissa4Yassine Ben Lahlou5Mostafa Elouennass6Adil Maleb7Laboratory of Microbiology, Faculty of Medicine and Pharmacy, University Mohammed the First, Oujda, Morocco; Laboratory of Microbiology, Mohammed VI University Hospital, Oujda, MoroccoLaboratory of Microbiology, Faculty of Medicine and Pharmacy, University Mohammed the First, Oujda, Morocco; Laboratory of Microbiology, Mohammed VI University Hospital, Oujda, MoroccoLaboratory of Microbiology, Faculty of Medicine and Pharmacy, University Mohammed the First, Oujda, Morocco; Laboratory of Microbiology, Mohammed VI University Hospital, Oujda, MoroccoLaboratory of Microbiology, Faculty of Medicine and Pharmacy, University Mohammed the First, Oujda, MoroccoDepartment of Bacteriology, Mohammed V Teaching Military Hospital, Rabat, Morocco; Epidemiology and Bacterial Resistance Research Team/BIO-INOVA Centre, Faculty of Medicine and Pharmacy, University Mohammed V, Rabat, MoroccoDepartment of Bacteriology, Mohammed V Teaching Military Hospital, Rabat, Morocco; Epidemiology and Bacterial Resistance Research Team/BIO-INOVA Centre, Faculty of Medicine and Pharmacy, University Mohammed V, Rabat, MoroccoDepartment of Bacteriology, Mohammed V Teaching Military Hospital, Rabat, Morocco; Epidemiology and Bacterial Resistance Research Team/BIO-INOVA Centre, Faculty of Medicine and Pharmacy, University Mohammed V, Rabat, MoroccoLaboratory of Microbiology, Faculty of Medicine and Pharmacy, University Mohammed the First, Oujda, Morocco; Laboratory of Microbiology, Mohammed VI University Hospital, Oujda, Morocco; Laboratory of Bioresources, Biotechnology, Ethnopharmacology and Health, Faculty of Sciences, University Mohammed the First, Oujda, MoroccoBackground and Objectives: Helicobacter pylori, identified in 1982, remains a major cause of gastric infections. Despite extensive research, an ideal treatment regimen for its eradication is yet to be determined, with antibiotic resistance posing a significant challenge. This study, conducted at Mohammed VI University Hospital, aimed to evaluate and compare the effectiveness of different therapeutic protocols for H. pylori eradication. Materials and Methods: This 13-month retrospective descriptive study was conducted at the Microbiology Laboratory of Mohammed VI University Hospital in Oujda, Morocco, to evaluate patients suspected of H. pylori infection using the urea breath test. Results: A total of 190 patients were included, with an overall eradication rate of 73%. Three therapeutic protocols were tested, and bismuth concomitant therapy showed the highest eradication rate at 82%, outperforming the other regimens. Conclusion: These findings highlight the importance of combining antimicrobial agents with antisecretory treatments to enhance eradication outcomes. The study also emphasizes the need for novel treatment strategies, particularly in light of rising antibiotic resistance. Vonoprazan-based regimens appear to offer a promising alternative, especially in the absence of antibiotic sensitivity testing. Future research should focus on optimizing treatment protocols while preserving beneficial gut flora. https://ijm.tums.ac.ir/index.php/ijm/article/view/5155Helicobacter pyloriUrea breath testAntibiotic resistanceEradicationAntimicrobial therapyTreatment protocols |
| spellingShingle | Yousra Sbibih Abderrazak Saddari Ilham Alla Said Ezrari Elmostapha Benaissa Yassine Ben Lahlou Mostafa Elouennass Adil Maleb Eradication of Helicobacter pylori: challenges and advances Iranian Journal of Microbiology Helicobacter pylori Urea breath test Antibiotic resistance Eradication Antimicrobial therapy Treatment protocols |
| title | Eradication of Helicobacter pylori: challenges and advances |
| title_full | Eradication of Helicobacter pylori: challenges and advances |
| title_fullStr | Eradication of Helicobacter pylori: challenges and advances |
| title_full_unstemmed | Eradication of Helicobacter pylori: challenges and advances |
| title_short | Eradication of Helicobacter pylori: challenges and advances |
| title_sort | eradication of helicobacter pylori challenges and advances |
| topic | Helicobacter pylori Urea breath test Antibiotic resistance Eradication Antimicrobial therapy Treatment protocols |
| url | https://ijm.tums.ac.ir/index.php/ijm/article/view/5155 |
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