Effects of Inositol(s) in Women with PCOS: A Systematic Review of Randomized Controlled Trials
Polycystic ovary syndrome (PCOS) is a common endocrine disorder, with complex etiology and pathophysiology, which remains poorly understood. It affects about 5–10% of women of reproductive age who typically suffer from obesity, hyperandrogenism, ovarian dysfunction, and menstrual irregularity. Indee...
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| Format: | Article |
| Language: | English |
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Wiley
2016-01-01
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| Series: | International Journal of Endocrinology |
| Online Access: | http://dx.doi.org/10.1155/2016/1849162 |
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| author | Vittorio Unfer John E. Nestler Zdravko A. Kamenov Nikos Prapas Fabio Facchinetti |
| author_facet | Vittorio Unfer John E. Nestler Zdravko A. Kamenov Nikos Prapas Fabio Facchinetti |
| author_sort | Vittorio Unfer |
| collection | DOAJ |
| description | Polycystic ovary syndrome (PCOS) is a common endocrine disorder, with complex etiology and pathophysiology, which remains poorly understood. It affects about 5–10% of women of reproductive age who typically suffer from obesity, hyperandrogenism, ovarian dysfunction, and menstrual irregularity. Indeed, PCOS is the most common cause of anovulatory infertility in industrialized nations, and it is associated with insulin resistance, type 2 diabetes mellitus, and increased cardiovascular risk. Although insulin resistance is not included as a criterion for diagnosis, it is a critical pathological condition of PCOS. The purpose of this systematic review is the analysis of recent randomized clinical trials of inositol(s) in PCOS, in particular myo- and D-chiro-inositol, in order to better elucidate their physiological involvement in PCOS and potential therapeutic use, alone and in conjunction with assisted reproductive technologies, in the clinical treatment of women with PCOS. |
| format | Article |
| id | doaj-art-db84fc63e7dd4ed99794f4157b3d3796 |
| institution | Kabale University |
| issn | 1687-8337 1687-8345 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Endocrinology |
| spelling | doaj-art-db84fc63e7dd4ed99794f4157b3d37962025-02-03T06:00:28ZengWileyInternational Journal of Endocrinology1687-83371687-83452016-01-01201610.1155/2016/18491621849162Effects of Inositol(s) in Women with PCOS: A Systematic Review of Randomized Controlled TrialsVittorio Unfer0John E. Nestler1Zdravko A. Kamenov2Nikos Prapas3Fabio Facchinetti4Department of Medical Sciences, IPUS-Institute of Higher Education, Chiasso, SwitzerlandDepartment of Medicine and Department of Obstetrics and Gynecology, Virginia Commonwealth University, Richmond, VA, USAClinic of Endocrinology, Alexandrovska University Hospital, Medical University, Sofia, BulgariaIAKENTRO, Infertility Treatment Center, Thessaloniki, GreeceMother-Infant Department, University of Modena and Reggio Emilia, Modena, ItalyPolycystic ovary syndrome (PCOS) is a common endocrine disorder, with complex etiology and pathophysiology, which remains poorly understood. It affects about 5–10% of women of reproductive age who typically suffer from obesity, hyperandrogenism, ovarian dysfunction, and menstrual irregularity. Indeed, PCOS is the most common cause of anovulatory infertility in industrialized nations, and it is associated with insulin resistance, type 2 diabetes mellitus, and increased cardiovascular risk. Although insulin resistance is not included as a criterion for diagnosis, it is a critical pathological condition of PCOS. The purpose of this systematic review is the analysis of recent randomized clinical trials of inositol(s) in PCOS, in particular myo- and D-chiro-inositol, in order to better elucidate their physiological involvement in PCOS and potential therapeutic use, alone and in conjunction with assisted reproductive technologies, in the clinical treatment of women with PCOS.http://dx.doi.org/10.1155/2016/1849162 |
| spellingShingle | Vittorio Unfer John E. Nestler Zdravko A. Kamenov Nikos Prapas Fabio Facchinetti Effects of Inositol(s) in Women with PCOS: A Systematic Review of Randomized Controlled Trials International Journal of Endocrinology |
| title | Effects of Inositol(s) in Women with PCOS: A Systematic Review of Randomized Controlled Trials |
| title_full | Effects of Inositol(s) in Women with PCOS: A Systematic Review of Randomized Controlled Trials |
| title_fullStr | Effects of Inositol(s) in Women with PCOS: A Systematic Review of Randomized Controlled Trials |
| title_full_unstemmed | Effects of Inositol(s) in Women with PCOS: A Systematic Review of Randomized Controlled Trials |
| title_short | Effects of Inositol(s) in Women with PCOS: A Systematic Review of Randomized Controlled Trials |
| title_sort | effects of inositol s in women with pcos a systematic review of randomized controlled trials |
| url | http://dx.doi.org/10.1155/2016/1849162 |
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