Expression of the cellular prion protein by mast cells in white-tailed deer carotid body, cervical lymph nodes and ganglia
Chronic wasting disease (CWD) is a transmissible and fatal prion disease that affects cervids. While both oral and nasal routes of exposure to prions cause disease, the spatial and temporal details of how prions enter the central nervous system (CNS) are unknown. Carotid bodies (CBs) are structures...
Saved in:
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Taylor & Francis Group
2024-12-01
|
| Series: | Prion |
| Subjects: | |
| Online Access: | https://www.tandfonline.com/doi/10.1080/19336896.2024.2402225 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832096708827283456 |
|---|---|
| author | Anthony E. Kincaid Nathaniel D. Denkers Erin E. McNulty Caitlyn N. Kraft Jason C. Bartz Candace K. Mathiason |
| author_facet | Anthony E. Kincaid Nathaniel D. Denkers Erin E. McNulty Caitlyn N. Kraft Jason C. Bartz Candace K. Mathiason |
| author_sort | Anthony E. Kincaid |
| collection | DOAJ |
| description | Chronic wasting disease (CWD) is a transmissible and fatal prion disease that affects cervids. While both oral and nasal routes of exposure to prions cause disease, the spatial and temporal details of how prions enter the central nervous system (CNS) are unknown. Carotid bodies (CBs) are structures that are exposed to blood-borne prions and are densely innervated by nerves that are directly connected to brainstem nuclei, known to be early sites of prion neuroinvasion. All CBs examined contained mast cells expressing the prion protein which is consistent with these cells playing a role in neuroinvasion following prionemia. |
| format | Article |
| id | doaj-art-db84cf1ce9474f5592e6a496db8c2459 |
| institution | Kabale University |
| issn | 1933-6896 1933-690X |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Prion |
| spelling | doaj-art-db84cf1ce9474f5592e6a496db8c24592025-02-05T12:40:51ZengTaylor & Francis GroupPrion1933-68961933-690X2024-12-011819410210.1080/19336896.2024.2402225Expression of the cellular prion protein by mast cells in white-tailed deer carotid body, cervical lymph nodes and gangliaAnthony E. Kincaid0Nathaniel D. Denkers1Erin E. McNulty2Caitlyn N. Kraft3Jason C. Bartz4Candace K. Mathiason5Department of Pharmacy Sciences, School of Pharmacy and Health Professions, Creighton University, Omaha, NE, USADepartment of Microbiology, Immunology and Pathology, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, CO, USADepartment of Microbiology, Immunology and Pathology, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, CO, USADepartment of Microbiology, Immunology and Pathology, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, CO, USADepartment of Medical Microbiology and Immunology, School of Medicine, Creighton University, Omaha, NE, USADepartment of Microbiology, Immunology and Pathology, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, CO, USAChronic wasting disease (CWD) is a transmissible and fatal prion disease that affects cervids. While both oral and nasal routes of exposure to prions cause disease, the spatial and temporal details of how prions enter the central nervous system (CNS) are unknown. Carotid bodies (CBs) are structures that are exposed to blood-borne prions and are densely innervated by nerves that are directly connected to brainstem nuclei, known to be early sites of prion neuroinvasion. All CBs examined contained mast cells expressing the prion protein which is consistent with these cells playing a role in neuroinvasion following prionemia.https://www.tandfonline.com/doi/10.1080/19336896.2024.2402225Carotid bodychronic wasting diseaselymph nodemast cellnodose ganglionprions |
| spellingShingle | Anthony E. Kincaid Nathaniel D. Denkers Erin E. McNulty Caitlyn N. Kraft Jason C. Bartz Candace K. Mathiason Expression of the cellular prion protein by mast cells in white-tailed deer carotid body, cervical lymph nodes and ganglia Prion Carotid body chronic wasting disease lymph node mast cell nodose ganglion prions |
| title | Expression of the cellular prion protein by mast cells in white-tailed deer carotid body, cervical lymph nodes and ganglia |
| title_full | Expression of the cellular prion protein by mast cells in white-tailed deer carotid body, cervical lymph nodes and ganglia |
| title_fullStr | Expression of the cellular prion protein by mast cells in white-tailed deer carotid body, cervical lymph nodes and ganglia |
| title_full_unstemmed | Expression of the cellular prion protein by mast cells in white-tailed deer carotid body, cervical lymph nodes and ganglia |
| title_short | Expression of the cellular prion protein by mast cells in white-tailed deer carotid body, cervical lymph nodes and ganglia |
| title_sort | expression of the cellular prion protein by mast cells in white tailed deer carotid body cervical lymph nodes and ganglia |
| topic | Carotid body chronic wasting disease lymph node mast cell nodose ganglion prions |
| url | https://www.tandfonline.com/doi/10.1080/19336896.2024.2402225 |
| work_keys_str_mv | AT anthonyekincaid expressionofthecellularprionproteinbymastcellsinwhitetaileddeercarotidbodycervicallymphnodesandganglia AT nathanielddenkers expressionofthecellularprionproteinbymastcellsinwhitetaileddeercarotidbodycervicallymphnodesandganglia AT erinemcnulty expressionofthecellularprionproteinbymastcellsinwhitetaileddeercarotidbodycervicallymphnodesandganglia AT caitlynnkraft expressionofthecellularprionproteinbymastcellsinwhitetaileddeercarotidbodycervicallymphnodesandganglia AT jasoncbartz expressionofthecellularprionproteinbymastcellsinwhitetaileddeercarotidbodycervicallymphnodesandganglia AT candacekmathiason expressionofthecellularprionproteinbymastcellsinwhitetaileddeercarotidbodycervicallymphnodesandganglia |