The significance of small noncoding RNAs in the pathogenesis of cardiovascular diseases
With the advancement of high-throughput sequencing and bioinformatics, an increasing number of overlooked small noncoding RNAs (sncRNAs) have emerged. These sncRNAs predominantly comprise transfer RNA-derived fragments (tsRNAs), PIWI-interacting RNAs (piRNAs), Ro-associated non-coding RNAs (RNYs or...
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| Format: | Article |
| Language: | English |
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KeAi Communications Co., Ltd.
2025-07-01
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| Series: | Genes and Diseases |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2352304224001399 |
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| author | Hemanyun Bai Fanji Meng Kangling Ke Lingyan Fang Weize Xu Haitao Huang Xiao Liang Weiyan Li Fengya Zeng Can Chen |
| author_facet | Hemanyun Bai Fanji Meng Kangling Ke Lingyan Fang Weize Xu Haitao Huang Xiao Liang Weiyan Li Fengya Zeng Can Chen |
| author_sort | Hemanyun Bai |
| collection | DOAJ |
| description | With the advancement of high-throughput sequencing and bioinformatics, an increasing number of overlooked small noncoding RNAs (sncRNAs) have emerged. These sncRNAs predominantly comprise transfer RNA-derived fragments (tsRNAs), PIWI-interacting RNAs (piRNAs), Ro-associated non-coding RNAs (RNYs or Y-RNAs), small nucleolar RNAs (snoRNAs), and small nuclear RNAs (snRNAs). Each of these RNA types possesses distinct biological properties and plays specific roles in both physiological and pathological processes. The differential expression of sncRNAs substantially affects the occurrence and progression of various systemic diseases. However, their roles in the cardiovascular system remain unclear. Therefore, understanding the functionality and mechanisms of sncRNAs in the cardiovascular system holds promise for identifying novel targets and strategies for the diagnosis, prevention, and treatment of cardiovascular diseases. This review examines the biological characteristics of sncRNAs and their potential roles in cardiovascular diseases. |
| format | Article |
| id | doaj-art-db841e35b3fd41418fe93b190e3cc849 |
| institution | DOAJ |
| issn | 2352-3042 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | KeAi Communications Co., Ltd. |
| record_format | Article |
| series | Genes and Diseases |
| spelling | doaj-art-db841e35b3fd41418fe93b190e3cc8492025-08-20T03:11:06ZengKeAi Communications Co., Ltd.Genes and Diseases2352-30422025-07-0112410134210.1016/j.gendis.2024.101342The significance of small noncoding RNAs in the pathogenesis of cardiovascular diseasesHemanyun Bai0Fanji Meng1Kangling Ke2Lingyan Fang3Weize Xu4Haitao Huang5Xiao Liang6Weiyan Li7Fengya Zeng8Can Chen9Department of Cardiology, The Second Affiliated Hospital of Guangdong Medical University, Zhanjiang, Guangdong 524002, China; Guangdong Medical University, Zhanjiang, Guangdong 524002, ChinaDepartment of Cardiology, The Second Affiliated Hospital of Guangdong Medical University, Zhanjiang, Guangdong 524002, China; Guangdong Medical University, Zhanjiang, Guangdong 524002, ChinaDepartment of Cardiology, The Second Affiliated Hospital of Guangdong Medical University, Zhanjiang, Guangdong 524002, China; Guangdong Medical University, Zhanjiang, Guangdong 524002, ChinaDepartment of Cardiology, The Second Affiliated Hospital of Guangdong Medical University, Zhanjiang, Guangdong 524002, ChinaDepartment of Cardiology, The Second Affiliated Hospital of Guangdong Medical University, Zhanjiang, Guangdong 524002, China; Guangdong Medical University, Zhanjiang, Guangdong 524002, ChinaDepartment of Cardiology, The Second Affiliated Hospital of Guangdong Medical University, Zhanjiang, Guangdong 524002, ChinaDepartment of Cardiology, The Second Affiliated Hospital of Guangdong Medical University, Zhanjiang, Guangdong 524002, ChinaDepartment of Cardiology, The Second Affiliated Hospital of Guangdong Medical University, Zhanjiang, Guangdong 524002, China; Guangdong Medical University, Zhanjiang, Guangdong 524002, ChinaDepartment of Cardiology, The Second Affiliated Hospital of Guangdong Medical University, Zhanjiang, Guangdong 524002, China; Guangdong Medical University, Zhanjiang, Guangdong 524002, ChinaDepartment of Cardiology, The Second Affiliated Hospital of Guangdong Medical University, Zhanjiang, Guangdong 524002, China; Corresponding author.With the advancement of high-throughput sequencing and bioinformatics, an increasing number of overlooked small noncoding RNAs (sncRNAs) have emerged. These sncRNAs predominantly comprise transfer RNA-derived fragments (tsRNAs), PIWI-interacting RNAs (piRNAs), Ro-associated non-coding RNAs (RNYs or Y-RNAs), small nucleolar RNAs (snoRNAs), and small nuclear RNAs (snRNAs). Each of these RNA types possesses distinct biological properties and plays specific roles in both physiological and pathological processes. The differential expression of sncRNAs substantially affects the occurrence and progression of various systemic diseases. However, their roles in the cardiovascular system remain unclear. Therefore, understanding the functionality and mechanisms of sncRNAs in the cardiovascular system holds promise for identifying novel targets and strategies for the diagnosis, prevention, and treatment of cardiovascular diseases. This review examines the biological characteristics of sncRNAs and their potential roles in cardiovascular diseases.http://www.sciencedirect.com/science/article/pii/S2352304224001399Biological functionBiomarkersCardiovascular diseasesGene regulationSncRNA |
| spellingShingle | Hemanyun Bai Fanji Meng Kangling Ke Lingyan Fang Weize Xu Haitao Huang Xiao Liang Weiyan Li Fengya Zeng Can Chen The significance of small noncoding RNAs in the pathogenesis of cardiovascular diseases Genes and Diseases Biological function Biomarkers Cardiovascular diseases Gene regulation SncRNA |
| title | The significance of small noncoding RNAs in the pathogenesis of cardiovascular diseases |
| title_full | The significance of small noncoding RNAs in the pathogenesis of cardiovascular diseases |
| title_fullStr | The significance of small noncoding RNAs in the pathogenesis of cardiovascular diseases |
| title_full_unstemmed | The significance of small noncoding RNAs in the pathogenesis of cardiovascular diseases |
| title_short | The significance of small noncoding RNAs in the pathogenesis of cardiovascular diseases |
| title_sort | significance of small noncoding rnas in the pathogenesis of cardiovascular diseases |
| topic | Biological function Biomarkers Cardiovascular diseases Gene regulation SncRNA |
| url | http://www.sciencedirect.com/science/article/pii/S2352304224001399 |
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