A green and robust LC–MS/MS bioanalytical method for sulopenem etzadroxil and probenecid: Optimization, validation, and pharmacokinetic application

A green and robust LC–MS/MS bioanalytical method for sulopenem etzadroxil and probenecid: Optimization, validation, and pharmacokinetic application

A novel, green, and robust Liquid chromatography–tandem mass spectrometry (LC–MS/MS) method was developed and validated for the simultaneous quantification of sulopenem etzadroxil and probenecid in rat plasma, with application to pharmacokinetic studies. Method development was guided by a Box–Behnke...

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Bibliographic Details
Main Authors: Niloufer Tasnim Khazi, Kumaraswamy Gandla, Lalitha Repudi
Format: Article
Language:English
Published: Elsevier 2025-12-01
Series:Journal of Pharmaceutical and Biomedical Analysis Open
Subjects:
Sulopenem etzadroxil
Probenecid
Meropenem
Pharmacokinetics
Bioanalytical method validation
Green analytical chemistry
Online Access:http://www.sciencedirect.com/science/article/pii/S2949771X25000349
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