Surveillance of pathogenic yeasts in hospital environments in Taiwan in 2020
Background: A predominate azole-resistant Candida tropicalis clade 4 genotype causing candidemia has been detected in not only Taiwan but also China, Singapore, and Australia. It can also be detected on fruit surfaces. In addition to determining distribution and drug susceptibilities of pathogenic y...
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2024-12-01
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| Series: | Journal of Microbiology, Immunology and Infection |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1684118224001567 |
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| author | De-Jiun Tsai Li-Yun Hsieh Pei-Jung Chung Yin-Zhi Chen Yi-Jyun Jhou Kuo-Yun Tseng Chia-Jui Yang Yen-Cheng Yeh Seng-Yi Lin Susan Shin-Jung Lee Ting-I Wu Tsung-Ta Chiang Chien-Hsuan Chou Wei-Chieh Miu Po-Yu Liu Chin-Te Lu Yuan-Ti Lee Yu-Ling Syu Gwo-Jong Hsu Yee-Chun Chen Nan-Yao Lee Chang-Hua Chen Ching-Cheng Yang Lih-Shinn Wang Jien-Wei Liu Chin-Chuan Kao Ya-Ting Chang Keh-Sen Liu Bor-Shen Hu Che-Han Hsu Yi-Ching Huang Hsiu-Jung Lo |
| author_facet | De-Jiun Tsai Li-Yun Hsieh Pei-Jung Chung Yin-Zhi Chen Yi-Jyun Jhou Kuo-Yun Tseng Chia-Jui Yang Yen-Cheng Yeh Seng-Yi Lin Susan Shin-Jung Lee Ting-I Wu Tsung-Ta Chiang Chien-Hsuan Chou Wei-Chieh Miu Po-Yu Liu Chin-Te Lu Yuan-Ti Lee Yu-Ling Syu Gwo-Jong Hsu Yee-Chun Chen Nan-Yao Lee Chang-Hua Chen Ching-Cheng Yang Lih-Shinn Wang Jien-Wei Liu Chin-Chuan Kao Ya-Ting Chang Keh-Sen Liu Bor-Shen Hu Che-Han Hsu Yi-Ching Huang Hsiu-Jung Lo |
| author_sort | De-Jiun Tsai |
| collection | DOAJ |
| description | Background: A predominate azole-resistant Candida tropicalis clade 4 genotype causing candidemia has been detected in not only Taiwan but also China, Singapore, and Australia. It can also be detected on fruit surfaces. In addition to determining distribution and drug susceptibilities of pathogenic yeasts in environments of intensive care units of 25 hospitals in Taiwan, we would also like to investigate whether the azole-resistant C. tropicalis exists in Taiwan's hospital environment. Methods: The swabs of hospital environments were collected from August to November in 2020 and were cultured for yeasts. The yeasts were identified by rDNA sequence and the antifungal susceptibilities of those isolates were determined by the broth microdilution method. Results: The average yeast-culture rate of hospitals was 9.4% (217/2299). Sinks had the highest yeast-positive culture rate (32.7%), followed by bedside tables (28.9%), floors (26.0%), water-dispenser buttons (23.8%), and TV controller/touch panels (19.0%). Of 262 identified isolates, Candida parapsilosis was the most common species, accounting for 22.1%, followed by Filobasidium uniguttulatum (18.3%), Candida albicans (9.5%), C. tropicalis (8.0%), Candida glabrata (Nakaseomyces glabratus) (6.9%), and 30 other species (35.1%). Of the 21 C. tropicalis isolates from 11 units in 9 hospitals, 15 diploid sequence types (DSTs) were identified. The two DST506 fluconazole-resistant ones belonged to clade 4. Conclusion: We detected not only various pathogenic yeast species but also the predominant clade 4 genotype of azole-resistant C. tropicalis. Our findings highlight and re-emphasize the importance of regular cleaning and disinfection practices. |
| format | Article |
| id | doaj-art-db784701c8534252b82510f23ef3896a |
| institution | Kabale University |
| issn | 1684-1182 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Microbiology, Immunology and Infection |
| spelling | doaj-art-db784701c8534252b82510f23ef3896a2024-12-19T10:53:05ZengElsevierJournal of Microbiology, Immunology and Infection1684-11822024-12-01576947956Surveillance of pathogenic yeasts in hospital environments in Taiwan in 2020De-Jiun Tsai0Li-Yun Hsieh1Pei-Jung Chung2Yin-Zhi Chen3Yi-Jyun Jhou4Kuo-Yun Tseng5Chia-Jui Yang6Yen-Cheng Yeh7Seng-Yi Lin8Susan Shin-Jung Lee9Ting-I Wu10Tsung-Ta Chiang11Chien-Hsuan Chou12Wei-Chieh Miu13Po-Yu Liu14Chin-Te Lu15Yuan-Ti Lee16Yu-Ling Syu17Gwo-Jong Hsu18Yee-Chun Chen19Nan-Yao Lee20Chang-Hua Chen21Ching-Cheng Yang22Lih-Shinn Wang23Jien-Wei Liu24Chin-Chuan Kao25Ya-Ting Chang26Keh-Sen Liu27Bor-Shen Hu28Che-Han Hsu29Yi-Ching Huang30Hsiu-Jung Lo31Taiwan Mycology Reference Center, National Institute of Infectious Diseases and Vaccinology, National Health Research Institutes, Miaoli County, TaiwanTaiwan Mycology Reference Center, National Institute of Infectious Diseases and Vaccinology, National Health Research Institutes, Miaoli County, TaiwanTaiwan Mycology Reference Center, National Institute of Infectious Diseases and Vaccinology, National Health Research Institutes, Miaoli County, TaiwanTaiwan Mycology Reference Center, National Institute of Infectious Diseases and Vaccinology, National Health Research Institutes, Miaoli County, TaiwanTaiwan Mycology Reference Center, National Institute of Infectious Diseases and Vaccinology, National Health Research Institutes, Miaoli County, TaiwanTaiwan Mycology Reference Center, National Institute of Infectious Diseases and Vaccinology, National Health Research Institutes, Miaoli County, TaiwanDepartment of Internal Medicine, Far Eastern Memorial Hospital, New Taipei, TaiwanDivision of Infectious Disease, Department of Medicine, Kaohsiung Armed Forces General Hospital, Kaohsiung, TaiwanDivision of Infectious Diseases, Department of Internal Medicine, Camillians Saint Mary's Hospital Luodong, Yilan County, TaiwanDivision of Infectious Diseases, Department of Internal Medicine, Kaohsiung Veterans General Hospital, Kaohsiung, TaiwanDepartment of Internal Medicine, Cathay General Hospital, Taipei, TaiwanDivision of Infection, Department of Internal Medicine, Tri-Service General Hospital, Taipei, TaiwanDepartment of Internal Medicine, Sin Lau Hospital, The Presbyterian Church of Taiwan, Tainan, TaiwanSection of Infectious Diseases, Mennonite Christian Hospital, Hualien, TaiwanDivision of Infection, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung, TaiwanDepartment of Infectious Diseases, Lo-Hsu Medical Foundation, Lotung Poh-Ai Hospital, Yilan County, TaiwanSchool of Medicine, Chung Shan Medical University, Taichung, TaiwanInfection Control Office, Hua-Lien Hospital, Ministry of Health and Welfare, Hualien, TaiwanDepartment of Internal Medicine, Ditmanson Medical Foundation Chia-Yi Christian Hospital, Chiayi, TaiwanCenter for Infection Control, National Taiwan University Hospital, Taipei, TaiwanDivision of Infectious Disease, Department of Internal Medicine and Center for Infection Control, National Cheng Kung University Hospital, Tainan, TaiwanSection of Infectious Diseases, Department of Internal Medicine, Changhua Christian Hospital, Changhua County, TaiwanDepartment of Infectious Diseases, Kuang Tien General Hospital, Taichung, TaiwanDivision of Infectious Diseases, Department of Internal Medicine, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Hualien, TaiwanDivision of Infectious Diseases, Department of Internal Medicine, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung, TaiwanDivision of Infectious Disease, Department of Internal Medicine, Tungs' Taichung Metroharbor Hospital, Taichung, TaiwanDivision of Infectious Diseases, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung, TaiwanDivision of Infectious Diseases, Department of Internal Medicine, Show Chwan Memorial Hospital, Changhua, TaiwanSection of Infectious Diseases, Department of Internal Medicine, Taipei City Hospital, Heping Branch, Taipei, TaiwanDivision of Infectious Diseases, Cheng Ching Hospital Chung Kang Branch, Taichung, TaiwanDivision of Infectious Diseases, Jen-Ai Hospital, Taichung, TaiwanTaiwan Mycology Reference Center, National Institute of Infectious Diseases and Vaccinology, National Health Research Institutes, Miaoli County, Taiwan; Department of Biological Science and Technology, National Yang Ming Chiao Tung University, Hsinchu, Taiwan; School of Dentistry, China Medical University, Taichung, Taiwan; Corresponding author. Taiwan Mycology Reference Center, National Institute of Infectious Diseases and Vaccinology, National Health Research Institutes, 35 Keyan Road, Zhunan, Miaoli County 350, Taiwan.Background: A predominate azole-resistant Candida tropicalis clade 4 genotype causing candidemia has been detected in not only Taiwan but also China, Singapore, and Australia. It can also be detected on fruit surfaces. In addition to determining distribution and drug susceptibilities of pathogenic yeasts in environments of intensive care units of 25 hospitals in Taiwan, we would also like to investigate whether the azole-resistant C. tropicalis exists in Taiwan's hospital environment. Methods: The swabs of hospital environments were collected from August to November in 2020 and were cultured for yeasts. The yeasts were identified by rDNA sequence and the antifungal susceptibilities of those isolates were determined by the broth microdilution method. Results: The average yeast-culture rate of hospitals was 9.4% (217/2299). Sinks had the highest yeast-positive culture rate (32.7%), followed by bedside tables (28.9%), floors (26.0%), water-dispenser buttons (23.8%), and TV controller/touch panels (19.0%). Of 262 identified isolates, Candida parapsilosis was the most common species, accounting for 22.1%, followed by Filobasidium uniguttulatum (18.3%), Candida albicans (9.5%), C. tropicalis (8.0%), Candida glabrata (Nakaseomyces glabratus) (6.9%), and 30 other species (35.1%). Of the 21 C. tropicalis isolates from 11 units in 9 hospitals, 15 diploid sequence types (DSTs) were identified. The two DST506 fluconazole-resistant ones belonged to clade 4. Conclusion: We detected not only various pathogenic yeast species but also the predominant clade 4 genotype of azole-resistant C. tropicalis. Our findings highlight and re-emphasize the importance of regular cleaning and disinfection practices.http://www.sciencedirect.com/science/article/pii/S1684118224001567CandidaHospital environmentDrug resistance |
| spellingShingle | De-Jiun Tsai Li-Yun Hsieh Pei-Jung Chung Yin-Zhi Chen Yi-Jyun Jhou Kuo-Yun Tseng Chia-Jui Yang Yen-Cheng Yeh Seng-Yi Lin Susan Shin-Jung Lee Ting-I Wu Tsung-Ta Chiang Chien-Hsuan Chou Wei-Chieh Miu Po-Yu Liu Chin-Te Lu Yuan-Ti Lee Yu-Ling Syu Gwo-Jong Hsu Yee-Chun Chen Nan-Yao Lee Chang-Hua Chen Ching-Cheng Yang Lih-Shinn Wang Jien-Wei Liu Chin-Chuan Kao Ya-Ting Chang Keh-Sen Liu Bor-Shen Hu Che-Han Hsu Yi-Ching Huang Hsiu-Jung Lo Surveillance of pathogenic yeasts in hospital environments in Taiwan in 2020 Journal of Microbiology, Immunology and Infection Candida Hospital environment Drug resistance |
| title | Surveillance of pathogenic yeasts in hospital environments in Taiwan in 2020 |
| title_full | Surveillance of pathogenic yeasts in hospital environments in Taiwan in 2020 |
| title_fullStr | Surveillance of pathogenic yeasts in hospital environments in Taiwan in 2020 |
| title_full_unstemmed | Surveillance of pathogenic yeasts in hospital environments in Taiwan in 2020 |
| title_short | Surveillance of pathogenic yeasts in hospital environments in Taiwan in 2020 |
| title_sort | surveillance of pathogenic yeasts in hospital environments in taiwan in 2020 |
| topic | Candida Hospital environment Drug resistance |
| url | http://www.sciencedirect.com/science/article/pii/S1684118224001567 |
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