Mining the bacterial genome to discover new antimicrobial molecules
Abstract Multidrug resistance is one of the major public health issues the world is facing today. However, the World Health Organization (WHO) revealed recently that there has been little progress in the development of new antibiotics to tackle drug‐resistant infections. By mining the bacterial geno...
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| Format: | Article |
| Language: | English |
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Springer Nature
2021-12-01
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| Series: | EMBO Molecular Medicine |
| Online Access: | https://doi.org/10.15252/emmm.202115409 |
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| _version_ | 1849343349510635520 |
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| author | Wenjie Liang Julien Diana |
| author_facet | Wenjie Liang Julien Diana |
| author_sort | Wenjie Liang |
| collection | DOAJ |
| description | Abstract Multidrug resistance is one of the major public health issues the world is facing today. However, the World Health Organization (WHO) revealed recently that there has been little progress in the development of new antibiotics to tackle drug‐resistant infections. By mining the bacterial genome database, Zhu et al, in the last issue of EMBO Molecular Medicine, report a defensin expressed by human oral actinomyces, actinomycesin, and characterize its anti‐infectious capacity (Zhu et al, 2021). They demonstrate the safety and efficacy of this bacterial antimicrobial peptide (AMP) against various bacterial strains, describe its mode of action, and validate its use as systemic drug therapy against bacterial infections in mice. This study highlights human oral bacteria as a source of antimicrobial agents that need to be considered in the future to fight multidrug‐resistant bacteria. |
| format | Article |
| id | doaj-art-db7659e43b51440c92c79c554c33cb87 |
| institution | Kabale University |
| issn | 1757-4676 1757-4684 |
| language | English |
| publishDate | 2021-12-01 |
| publisher | Springer Nature |
| record_format | Article |
| series | EMBO Molecular Medicine |
| spelling | doaj-art-db7659e43b51440c92c79c554c33cb872025-08-20T03:43:01ZengSpringer NatureEMBO Molecular Medicine1757-46761757-46842021-12-011421310.15252/emmm.202115409Mining the bacterial genome to discover new antimicrobial moleculesWenjie Liang0Julien Diana1Institut Necker Enfants Malades (INEM), Institut National de la Santé et de la Recherche Médicale (INSERM), Centre National de la Recherche Scientifique (CNRS), Université de ParisInstitut Necker Enfants Malades (INEM), Institut National de la Santé et de la Recherche Médicale (INSERM), Centre National de la Recherche Scientifique (CNRS), Université de ParisAbstract Multidrug resistance is one of the major public health issues the world is facing today. However, the World Health Organization (WHO) revealed recently that there has been little progress in the development of new antibiotics to tackle drug‐resistant infections. By mining the bacterial genome database, Zhu et al, in the last issue of EMBO Molecular Medicine, report a defensin expressed by human oral actinomyces, actinomycesin, and characterize its anti‐infectious capacity (Zhu et al, 2021). They demonstrate the safety and efficacy of this bacterial antimicrobial peptide (AMP) against various bacterial strains, describe its mode of action, and validate its use as systemic drug therapy against bacterial infections in mice. This study highlights human oral bacteria as a source of antimicrobial agents that need to be considered in the future to fight multidrug‐resistant bacteria.https://doi.org/10.15252/emmm.202115409 |
| spellingShingle | Wenjie Liang Julien Diana Mining the bacterial genome to discover new antimicrobial molecules EMBO Molecular Medicine |
| title | Mining the bacterial genome to discover new antimicrobial molecules |
| title_full | Mining the bacterial genome to discover new antimicrobial molecules |
| title_fullStr | Mining the bacterial genome to discover new antimicrobial molecules |
| title_full_unstemmed | Mining the bacterial genome to discover new antimicrobial molecules |
| title_short | Mining the bacterial genome to discover new antimicrobial molecules |
| title_sort | mining the bacterial genome to discover new antimicrobial molecules |
| url | https://doi.org/10.15252/emmm.202115409 |
| work_keys_str_mv | AT wenjieliang miningthebacterialgenometodiscovernewantimicrobialmolecules AT juliendiana miningthebacterialgenometodiscovernewantimicrobialmolecules |