Reshaping Resistance: How Autovaccine Therapy Alters the Course of Recurrent Multidrug-Resistant Urinary Tract Infections
Background/Objectives: Urinary tract infections (UTIs) caused by multidrug-resistant (MDR) bacteria pose a considerable challenge due to high treatment failure rates and associated healthcare costs. This pioneering study evaluates the effectiveness of personalized autovaccine therapy in managing rec...
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MDPI AG
2025-01-01
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| Online Access: | https://www.mdpi.com/2075-1729/15/1/50 |
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| author | Alexandru Ciudin Bernat Padulles Pasqualino Manasia Josep Alcoberro Cristian Toma Răzvan Popescu Cristian Persu Antonio Aguilar |
| author_facet | Alexandru Ciudin Bernat Padulles Pasqualino Manasia Josep Alcoberro Cristian Toma Răzvan Popescu Cristian Persu Antonio Aguilar |
| author_sort | Alexandru Ciudin |
| collection | DOAJ |
| description | Background/Objectives: Urinary tract infections (UTIs) caused by multidrug-resistant (MDR) bacteria pose a considerable challenge due to high treatment failure rates and associated healthcare costs. This pioneering study evaluates the effectiveness of personalized autovaccine therapy in managing recurrent UTIs in patients with MDR bacteria, aiming to offer an innovative treatment that reduces antibiotic resistance and hospitalizations. Methods: In this prospective, single-center study, 40 patients with recurrent MDR UTIs received personalized sublingual autovaccines derived from their own bacterial isolates. The study assessed UTI recurrence rates, changes in antibiotic use, and hospitalization days over 12 months. Results: The autovaccine therapy significantly reduced UTI recurrence, with 67.5% of patients experiencing fewer infections. Antibiotic usage decreased by 74.4%, and total hospitalization days annually reduced from 400 to 216. A significant shift was observed from MDR to multi-susceptible bacterial profiles among participants. Conclusions: This study is the first to demonstrate that autovaccine therapy is a safe and effective approach for managing recurrent UTIs caused by MDR bacteria, significantly lowering infection frequency, antibiotic needs, and hospitalization. These findings support integrating autovaccine therapy into standard UTI management to combat antibiotic resistance and lessen healthcare burdens. |
| format | Article |
| id | doaj-art-db759f723288492ab454f646c558c014 |
| institution | Kabale University |
| issn | 2075-1729 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Life |
| spelling | doaj-art-db759f723288492ab454f646c558c0142025-01-24T13:38:35ZengMDPI AGLife2075-17292025-01-011515010.3390/life15010050Reshaping Resistance: How Autovaccine Therapy Alters the Course of Recurrent Multidrug-Resistant Urinary Tract InfectionsAlexandru Ciudin0Bernat Padulles1Pasqualino Manasia2Josep Alcoberro3Cristian Toma4Răzvan Popescu5Cristian Persu6Antonio Aguilar7Urology Department, Hospital Universitari de Mollet, 08100 Barcelona, SpainUrology Department, Hospital Universitari de Mollet, 08100 Barcelona, SpainUrology Department, Hospital Universitari de Mollet, 08100 Barcelona, SpainUrology Department, Hospital Universitari de Mollet, 08100 Barcelona, SpainUrology Department, Spitalul Clinic “Prof. Dr. Th. Burghele”, 061344 Bucuresti, RomaniaUrology Department, Spitalul Clinic “Prof. Dr. Th. Burghele”, 061344 Bucuresti, RomaniaUrology Department, Spitalul Clinic “Prof. Dr. Th. Burghele”, 061344 Bucuresti, RomaniaUrology Department, Hospital Universitari de Mollet, 08100 Barcelona, SpainBackground/Objectives: Urinary tract infections (UTIs) caused by multidrug-resistant (MDR) bacteria pose a considerable challenge due to high treatment failure rates and associated healthcare costs. This pioneering study evaluates the effectiveness of personalized autovaccine therapy in managing recurrent UTIs in patients with MDR bacteria, aiming to offer an innovative treatment that reduces antibiotic resistance and hospitalizations. Methods: In this prospective, single-center study, 40 patients with recurrent MDR UTIs received personalized sublingual autovaccines derived from their own bacterial isolates. The study assessed UTI recurrence rates, changes in antibiotic use, and hospitalization days over 12 months. Results: The autovaccine therapy significantly reduced UTI recurrence, with 67.5% of patients experiencing fewer infections. Antibiotic usage decreased by 74.4%, and total hospitalization days annually reduced from 400 to 216. A significant shift was observed from MDR to multi-susceptible bacterial profiles among participants. Conclusions: This study is the first to demonstrate that autovaccine therapy is a safe and effective approach for managing recurrent UTIs caused by MDR bacteria, significantly lowering infection frequency, antibiotic needs, and hospitalization. These findings support integrating autovaccine therapy into standard UTI management to combat antibiotic resistance and lessen healthcare burdens.https://www.mdpi.com/2075-1729/15/1/50autovaccine therapymultidrug-resistant bacteriaurinary tract infections (UTIs)antibiotic resistancepersonalized medicinebacterial immunotherapy |
| spellingShingle | Alexandru Ciudin Bernat Padulles Pasqualino Manasia Josep Alcoberro Cristian Toma Răzvan Popescu Cristian Persu Antonio Aguilar Reshaping Resistance: How Autovaccine Therapy Alters the Course of Recurrent Multidrug-Resistant Urinary Tract Infections Life autovaccine therapy multidrug-resistant bacteria urinary tract infections (UTIs) antibiotic resistance personalized medicine bacterial immunotherapy |
| title | Reshaping Resistance: How Autovaccine Therapy Alters the Course of Recurrent Multidrug-Resistant Urinary Tract Infections |
| title_full | Reshaping Resistance: How Autovaccine Therapy Alters the Course of Recurrent Multidrug-Resistant Urinary Tract Infections |
| title_fullStr | Reshaping Resistance: How Autovaccine Therapy Alters the Course of Recurrent Multidrug-Resistant Urinary Tract Infections |
| title_full_unstemmed | Reshaping Resistance: How Autovaccine Therapy Alters the Course of Recurrent Multidrug-Resistant Urinary Tract Infections |
| title_short | Reshaping Resistance: How Autovaccine Therapy Alters the Course of Recurrent Multidrug-Resistant Urinary Tract Infections |
| title_sort | reshaping resistance how autovaccine therapy alters the course of recurrent multidrug resistant urinary tract infections |
| topic | autovaccine therapy multidrug-resistant bacteria urinary tract infections (UTIs) antibiotic resistance personalized medicine bacterial immunotherapy |
| url | https://www.mdpi.com/2075-1729/15/1/50 |
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