Derangement in Nicotinamide Adenine Dinucleotide Metabolism is Observed During Acute Kidney Injury Among Male Agricultural Workers at Risk for Mesoamerican Nephropathy

Derangement in Nicotinamide Adenine Dinucleotide Metabolism is Observed During Acute Kidney Injury Among Male Agricultural Workers at Risk for Mesoamerican Nephropathy

Introduction: Mesoamerican nephropathy (MeN) is a chronic kidney disease (CKD) which may be caused by recurrent acute kidney injury (AKI). We investigated urinary quinolinate-to-tryptophan ratio (Q/T), a validated marker of nicotinamide adenine dinucleotide (NAD+) biosynthesis that is elevated durin...

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Main Authors: Nathan H. Raines, Dominic A. Leone, Juan Jose Amador, Damaris Lopez-Pilarte, Oriana Ramírez-Rubio, Iris S. Delgado, Lauren J. Francey, Jessica H. Leibler, John M. Asara, Madeleine K. Scammell, Samir M. Parikh, Daniel R. Brooks, David J. Friedman
Format: Article
Language:English
Published: Elsevier 2024-07-01
Series:Kidney International Reports
Subjects:
acute kidney injury (AKI)
chronic kidney disease of unknown etiology (CKDu)
chronic kidney disease of nontraditional cause (CKDnt)
Mesoamerican nephropathy
metabolomics
nicotinamide adenine dinucleotide (NAD+)
Online Access:http://www.sciencedirect.com/science/article/pii/S2468024924016504
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