Gestational exposure to particulate matter from urban wildfires is associated with changes in circulating oxylipins but not flame retardants 7 to 13 months post-exposure
Exposure to fine particulate matter (PM2.5) from wildfire smoke has been linked to immune dysregulation underlying multiple health conditions, but data on the long-term effects of these exposures during gestation are lacking. Smoke PM2.5 from wildfires occurring in urban areas is of particular conce...
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Elsevier
2025-06-01
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| Series: | Environment International |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S0160412025002193 |
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| author | Eunyoung Park Qing Shen Zhichao Zhang Claire E. O’Brien Amanda J. Goodrich Elizabeth E. Angel Irva Hertz-Picciotto Daniel J. Tancredi Sean Raffuse Deborah H. Bennett Rebecca J. Schmidt Ameer Y. Taha |
| author_facet | Eunyoung Park Qing Shen Zhichao Zhang Claire E. O’Brien Amanda J. Goodrich Elizabeth E. Angel Irva Hertz-Picciotto Daniel J. Tancredi Sean Raffuse Deborah H. Bennett Rebecca J. Schmidt Ameer Y. Taha |
| author_sort | Eunyoung Park |
| collection | DOAJ |
| description | Exposure to fine particulate matter (PM2.5) from wildfire smoke has been linked to immune dysregulation underlying multiple health conditions, but data on the long-term effects of these exposures during gestation are lacking. Smoke PM2.5 from wildfires occurring in urban areas is of particular concern because it can carry persistent chemicals within household furniture or soil, as well as polyaromatic hydrocarbons (PAHs) from combusted materials. The present study investigated the long-term associations between wildfire PM2.5 and serum polybrominated diphenyl ethers (PBDEs), polychlorinated biphenyls (PCBs), PAHs and lipid mediators (i.e., oxylipins) involved in immune regulation in participants from the B-SAFE (Bio-Specimen Assessment of Fire Effects) study, which enrolled women pregnant during or shortly after the 2017 Tubbs Fire in California (n = 140). Serum samples were collected and assayed 7 to 13 months post-exposure, at which point 20 women were still pregnant and 120 women were postpartum. Adjusted linear regression models revealed a significant positive association between increasing PM2.5 (μg/m3) exposure and serum concentrations of benzo[k]fluoranthene, a PAH (β = 0.866, P = 0.0403, [95 %CI: 0.0389, 1.69]). No significant associations were observed between PM2.5 exposure and serum PBDEs, PCBs or other PAHs. Increased exposure to PM2.5 was associated with lower serum concentrations of lipoxygenase (LOX)-derived free oxylipins and increased concentrations of LOX-derived oxylipins esterified to circulating lipids. These findings provide new evidence of long-term effects of gestational wildfire PM2.5 exposure on serum benzo[k]fluoranthene levels and the turnover of oxylipins involved in immunity via the LOX pathway. Additional studies are warranted to better understand the impact of these changes on maternal and child health. |
| format | Article |
| id | doaj-art-db7113d65ddb4b35b971396a8a53d77b |
| institution | OA Journals |
| issn | 0160-4120 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Elsevier |
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| series | Environment International |
| spelling | doaj-art-db7113d65ddb4b35b971396a8a53d77b2025-08-20T02:32:30ZengElsevierEnvironment International0160-41202025-06-0120010946810.1016/j.envint.2025.109468Gestational exposure to particulate matter from urban wildfires is associated with changes in circulating oxylipins but not flame retardants 7 to 13 months post-exposureEunyoung Park0Qing Shen1Zhichao Zhang2Claire E. O’Brien3Amanda J. Goodrich4Elizabeth E. Angel5Irva Hertz-Picciotto6Daniel J. Tancredi7Sean Raffuse8Deborah H. Bennett9Rebecca J. Schmidt10Ameer Y. Taha11Department of Food Science and Technology, University of California Davis, Davis, CA, USADepartment of Food Science and Technology, University of California Davis, Davis, CA, USADepartment of Food Science and Technology, University of California Davis, Davis, CA, USADepartment of Food Science and Technology, University of California Davis, Davis, CA, USADepartment of Public Health Sciences, School of Medicine, University of California Davis, Sacramento, CA, USADepartment of Public Health Sciences, School of Medicine, University of California Davis, Sacramento, CA, USADepartment of Public Health Sciences, School of Medicine, University of California Davis, Sacramento, CA, USA; MIND Institute, University of California Davis, Sacramento 95817 CA, USADepartment of Pediatrics, University of California Davis, Sacramento, CA, USAAir Quality Research Center, University of California Davis, Davis, CA, USADepartment of Public Health Sciences, School of Medicine, University of California Davis, Sacramento, CA, USADepartment of Public Health Sciences, School of Medicine, University of California Davis, Sacramento, CA, USA; MIND Institute, University of California Davis, Sacramento 95817 CA, USADepartment of Food Science and Technology, University of California Davis, Davis, CA, USA; West Coast Metabolomics Center, Genome Center, University of California Davis, Davis, CA, USA; Center for Neuroscience, University of California Davis, Davis, CA, USA; Corresponding author at: RMI North, Department of Food Science and Technology, College of Agriculture and Environmental Sciences, University of California, Davis, CA, USA.Exposure to fine particulate matter (PM2.5) from wildfire smoke has been linked to immune dysregulation underlying multiple health conditions, but data on the long-term effects of these exposures during gestation are lacking. Smoke PM2.5 from wildfires occurring in urban areas is of particular concern because it can carry persistent chemicals within household furniture or soil, as well as polyaromatic hydrocarbons (PAHs) from combusted materials. The present study investigated the long-term associations between wildfire PM2.5 and serum polybrominated diphenyl ethers (PBDEs), polychlorinated biphenyls (PCBs), PAHs and lipid mediators (i.e., oxylipins) involved in immune regulation in participants from the B-SAFE (Bio-Specimen Assessment of Fire Effects) study, which enrolled women pregnant during or shortly after the 2017 Tubbs Fire in California (n = 140). Serum samples were collected and assayed 7 to 13 months post-exposure, at which point 20 women were still pregnant and 120 women were postpartum. Adjusted linear regression models revealed a significant positive association between increasing PM2.5 (μg/m3) exposure and serum concentrations of benzo[k]fluoranthene, a PAH (β = 0.866, P = 0.0403, [95 %CI: 0.0389, 1.69]). No significant associations were observed between PM2.5 exposure and serum PBDEs, PCBs or other PAHs. Increased exposure to PM2.5 was associated with lower serum concentrations of lipoxygenase (LOX)-derived free oxylipins and increased concentrations of LOX-derived oxylipins esterified to circulating lipids. These findings provide new evidence of long-term effects of gestational wildfire PM2.5 exposure on serum benzo[k]fluoranthene levels and the turnover of oxylipins involved in immunity via the LOX pathway. Additional studies are warranted to better understand the impact of these changes on maternal and child health.http://www.sciencedirect.com/science/article/pii/S0160412025002193Lipid mediatorsFlame retardantsPAHWildfireParticulate matterImmune response |
| spellingShingle | Eunyoung Park Qing Shen Zhichao Zhang Claire E. O’Brien Amanda J. Goodrich Elizabeth E. Angel Irva Hertz-Picciotto Daniel J. Tancredi Sean Raffuse Deborah H. Bennett Rebecca J. Schmidt Ameer Y. Taha Gestational exposure to particulate matter from urban wildfires is associated with changes in circulating oxylipins but not flame retardants 7 to 13 months post-exposure Environment International Lipid mediators Flame retardants PAH Wildfire Particulate matter Immune response |
| title | Gestational exposure to particulate matter from urban wildfires is associated with changes in circulating oxylipins but not flame retardants 7 to 13 months post-exposure |
| title_full | Gestational exposure to particulate matter from urban wildfires is associated with changes in circulating oxylipins but not flame retardants 7 to 13 months post-exposure |
| title_fullStr | Gestational exposure to particulate matter from urban wildfires is associated with changes in circulating oxylipins but not flame retardants 7 to 13 months post-exposure |
| title_full_unstemmed | Gestational exposure to particulate matter from urban wildfires is associated with changes in circulating oxylipins but not flame retardants 7 to 13 months post-exposure |
| title_short | Gestational exposure to particulate matter from urban wildfires is associated with changes in circulating oxylipins but not flame retardants 7 to 13 months post-exposure |
| title_sort | gestational exposure to particulate matter from urban wildfires is associated with changes in circulating oxylipins but not flame retardants 7 to 13 months post exposure |
| topic | Lipid mediators Flame retardants PAH Wildfire Particulate matter Immune response |
| url | http://www.sciencedirect.com/science/article/pii/S0160412025002193 |
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