Clonal Hematopoiesis, a Risk Condition for Developing Myeloid Neoplasia
Clonal hematopoiesis (CH) is an age-related process in which hematopoietic stem/progenitor cells increase their fitness due to the acquisition of mutations that lead to a proliferative advantage and to clonal expansion. Its frequency increases with age, and it mostly affects people older than 70 yea...
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MDPI AG
2025-04-01
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| Online Access: | https://www.mdpi.com/2673-6357/6/2/10 |
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| author | Ugo Testa Germana Castelli Elvira Pelosi |
| author_facet | Ugo Testa Germana Castelli Elvira Pelosi |
| author_sort | Ugo Testa |
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| description | Clonal hematopoiesis (CH) is an age-related process in which hematopoietic stem/progenitor cells increase their fitness due to the acquisition of mutations that lead to a proliferative advantage and to clonal expansion. Its frequency increases with age, and it mostly affects people older than 70 years. The most mutated genes in CH are epigenetic regulators, DNA damage response genes, and splicing factors, which are all involved in the development of myeloid neoplasia. Some risk factors, including age, smoking, and prior cytotoxic therapy, increase the risk of developing CH or increase the fitness of CH. Various types of CH have been observed, associated or not with cytopenias or monocytosis. CH represents a risk factor for many pathological conditions and particularly for hematologic malignancies. A better understanding of the risks related to CH has triggered the development of research, translational, and clinical programs for the monitoring, prevention, and treatment of CH. |
| format | Article |
| id | doaj-art-db6f0d0a83a84044b5d7b948ca6477be |
| institution | Kabale University |
| issn | 2673-6357 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Hemato |
| spelling | doaj-art-db6f0d0a83a84044b5d7b948ca6477be2025-08-20T03:27:29ZengMDPI AGHemato2673-63572025-04-01621010.3390/hemato6020010Clonal Hematopoiesis, a Risk Condition for Developing Myeloid NeoplasiaUgo Testa0Germana Castelli1Elvira Pelosi2Ugo Testa, Department of Oncology, Istituto Speriore di Sanità, Viale Regina Elena 299, 00161 Rome, ItalyUgo Testa, Department of Oncology, Istituto Speriore di Sanità, Viale Regina Elena 299, 00161 Rome, ItalyUgo Testa, Department of Oncology, Istituto Speriore di Sanità, Viale Regina Elena 299, 00161 Rome, ItalyClonal hematopoiesis (CH) is an age-related process in which hematopoietic stem/progenitor cells increase their fitness due to the acquisition of mutations that lead to a proliferative advantage and to clonal expansion. Its frequency increases with age, and it mostly affects people older than 70 years. The most mutated genes in CH are epigenetic regulators, DNA damage response genes, and splicing factors, which are all involved in the development of myeloid neoplasia. Some risk factors, including age, smoking, and prior cytotoxic therapy, increase the risk of developing CH or increase the fitness of CH. Various types of CH have been observed, associated or not with cytopenias or monocytosis. CH represents a risk factor for many pathological conditions and particularly for hematologic malignancies. A better understanding of the risks related to CH has triggered the development of research, translational, and clinical programs for the monitoring, prevention, and treatment of CH.https://www.mdpi.com/2673-6357/6/2/10clonal hematopoiesisleukemiamyelodysplasiahematopoietic stem cellsclonal evolutionclonal progression |
| spellingShingle | Ugo Testa Germana Castelli Elvira Pelosi Clonal Hematopoiesis, a Risk Condition for Developing Myeloid Neoplasia Hemato clonal hematopoiesis leukemia myelodysplasia hematopoietic stem cells clonal evolution clonal progression |
| title | Clonal Hematopoiesis, a Risk Condition for Developing Myeloid Neoplasia |
| title_full | Clonal Hematopoiesis, a Risk Condition for Developing Myeloid Neoplasia |
| title_fullStr | Clonal Hematopoiesis, a Risk Condition for Developing Myeloid Neoplasia |
| title_full_unstemmed | Clonal Hematopoiesis, a Risk Condition for Developing Myeloid Neoplasia |
| title_short | Clonal Hematopoiesis, a Risk Condition for Developing Myeloid Neoplasia |
| title_sort | clonal hematopoiesis a risk condition for developing myeloid neoplasia |
| topic | clonal hematopoiesis leukemia myelodysplasia hematopoietic stem cells clonal evolution clonal progression |
| url | https://www.mdpi.com/2673-6357/6/2/10 |
| work_keys_str_mv | AT ugotesta clonalhematopoiesisariskconditionfordevelopingmyeloidneoplasia AT germanacastelli clonalhematopoiesisariskconditionfordevelopingmyeloidneoplasia AT elvirapelosi clonalhematopoiesisariskconditionfordevelopingmyeloidneoplasia |