Proteoglycan 4 (Lubricin) and regulation of xanthine oxidase in synovial macrophage as a mechanism of controlling synovitis

Proteoglycan 4 (Lubricin) and regulation of xanthine oxidase in synovial macrophage as a mechanism of controlling synovitis

Abstract Background Synovial macrophages (SMs) are important effectors of joint health and disease. A novel Cx3CR1 + TREM2 + SM population expressing the tight junction protein claudin-5, was recently discovered in synovial lining. Ablation of these SMs was associated with onset of arthritis. Proteo...

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Bibliographic Details
Main Authors: Khaled A. Elsaid, Ling X. Zhang, Thomas Zhao, Ava Marks, Derek Jenkins, Tannin A. Schmidt, Gregory D. Jay
Format: Article
Language:English
Published: BMC 2024-12-01
Series:Arthritis Research & Therapy
Subjects:
PRG4
Xanthine oxidase
Febuxostat
Glycolysis
Synovial macrophages
Online Access:https://doi.org/10.1186/s13075-024-03455-x
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