The Imbalance Between Metalloproteinases and Their Tissue Inhibitors Is Involved in the Pathogenesis of Dermatitis Herpetiformis
Dermatitis herpetiformis (DH) is a subepidermal autoimmune disease characterized by skin and intestinal lesions consistent with coeliac disease. There are also some data that metalloproteinases (MMPs) are involved in the development of skin lesions in DH, however their exact role in this process is...
Saved in:
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2005-01-01
|
| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/MI.2005.373 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| Summary: | Dermatitis herpetiformis (DH) is a subepidermal autoimmune
disease characterized by skin and intestinal lesions consistent
with coeliac disease. There are also some data that
metalloproteinases (MMPs) are involved in the development of skin
lesions in DH, however their exact role in this process is not
fully understood. The aim of the study was to investigate whether
MMPs and their inhibitors are involved in pathogenesis of DH. Skin
biopsies were taken from 13 patients with active DH and from 10
healthy subjects. The localization and expression of MMPs and
TIMPs were examined by immunohistochemistry. MMPs expression was
detected in basal keratinocytes and in the whole epidermis in all
of the DH subjects. Neutrophils in microabscesses and in blister fluid
were also positive for MMPs. Expression of TIMPs was moderate or
weak in all examined biopsies. Our results allow us to conclude
that imbalance between these enzymes takes an important role in
the pathogenesis of DH. |
|---|---|
| ISSN: | 0962-9351 1466-1861 |