EXPRESSION OF ANGIOPOETIN ON THE KIDNEY TRANSPLANT WAITING LIST: A SINGLE-CENTER STUDY
Objective: Angiopoietin-2 (Ang-2) is a growth factor belonging to the angiopoietin (Ang)/Tie signaling pathway. Plasma levels of especially Ang- 2, are thought to be significantly increased in patients with acute kidney injury (AKI), independent of inflammation. Ang-2 is also important in dialysis a...
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Istanbul University Press
2023-10-01
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| Series: | Sabiad |
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| Online Access: | https://cdn.istanbul.edu.tr/file/JTA6CLJ8T5/9A9841D848344687B3FC6D39CFE7DD95 |
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| author | Süleyman Rüştü Oğuz Ayşe Sinangil Demet Kıvanç İzgi Soykan Barlas Hayriye Şentürk Çiftçi Kıymet Güzin Şen Tevfik Ecder Barış Akın |
| author_facet | Süleyman Rüştü Oğuz Ayşe Sinangil Demet Kıvanç İzgi Soykan Barlas Hayriye Şentürk Çiftçi Kıymet Güzin Şen Tevfik Ecder Barış Akın |
| author_sort | Süleyman Rüştü Oğuz |
| collection | DOAJ |
| description | Objective: Angiopoietin-2 (Ang-2) is a growth factor belonging to the angiopoietin (Ang)/Tie signaling pathway. Plasma levels of especially Ang- 2, are thought to be significantly increased in patients with acute kidney injury (AKI), independent of inflammation. Ang-2 is also important in dialysis and transplantation, as it plays an important role in the disruption of endothelial homeostasis. Our study aimed to investigate the relationship between anti-HLA antibody loads and Ang levels in patients with endstage renal disease (ESRD) who are on the organ transplant waiting list.Material and Method: 80 ESRD patients who were on the waiting list between 2018 and 2020 and whose panel reactive antibody (PRA) screening and identification test were studied participated in our study. First, the PRA screening test was performed on the patients, and the class I-II identification tests were studied on the patients who were positive for PRA. The Ang-2 level was evaluated by the ELISA method. The relationship between Ang-2 levels and PRA percentages in PRA positive and negative patients was evaluated.Results: A positive correlation was found between anti-HLA antibody and Ang-2 levels in patients with ESRD (class I, p=0.024; class II, p=0.032), and a statistically significant increase in Ang-2 level was found in patients with PRA ≥50% positive (class I, p=0.038) This finding suggests that Ang-2 may have an important role in the progression of chronic renal failure and may be effective in predicting graft survival after transplantation. Conclusions: Further studies will be required to fully elucidate the effect of Ang-2 on renal progression. |
| format | Article |
| id | doaj-art-db64274ffe5b4d50a70e443f0ba05a7e |
| institution | OA Journals |
| issn | 2651-4060 |
| language | English |
| publishDate | 2023-10-01 |
| publisher | Istanbul University Press |
| record_format | Article |
| series | Sabiad |
| spelling | doaj-art-db64274ffe5b4d50a70e443f0ba05a7e2025-08-20T02:27:31ZengIstanbul University PressSabiad2651-40602023-10-016323924310.26650/JARHS2023-1294442123456EXPRESSION OF ANGIOPOETIN ON THE KIDNEY TRANSPLANT WAITING LIST: A SINGLE-CENTER STUDYSüleyman Rüştü Oğuz0https://orcid.org/0000-0002-5854-1163Ayşe Sinangil1https://orcid.org/0000-0003-4001-6376Demet Kıvanç İzgi2https://orcid.org/0000-0002-2451-5709Soykan Barlas3https://orcid.org/0000-0003-0422-4960Hayriye Şentürk Çiftçi4https://orcid.org/0000-0001-5160-5227Kıymet Güzin Şen5https://orcid.org/0009-0005-6665-8803Tevfik Ecder6https://orcid.org/0000-0003-3394-5775Barış Akın7https://orcid.org/0000-0002-7410-3614Demiroğlu Bilim Üniversitesi, Istanbul, TurkiyeDemiroğlu Bilim Üniversitesi, Istanbul, Turkiyeİstanbul Üniversitesi, İstanbul, TürkiyeDemiroğlu Bilim Üniversitesi, Istanbul, Turkiyeİstanbul Üniversitesi, İstanbul, TürkiyeDemiroğlu Bilim Üniversitesi, Istanbul, TurkiyeDemiroğlu Bilim Üniversitesi, Istanbul, TurkiyeDemiroğlu Bilim Üniversitesi, Istanbul, TurkiyeObjective: Angiopoietin-2 (Ang-2) is a growth factor belonging to the angiopoietin (Ang)/Tie signaling pathway. Plasma levels of especially Ang- 2, are thought to be significantly increased in patients with acute kidney injury (AKI), independent of inflammation. Ang-2 is also important in dialysis and transplantation, as it plays an important role in the disruption of endothelial homeostasis. Our study aimed to investigate the relationship between anti-HLA antibody loads and Ang levels in patients with endstage renal disease (ESRD) who are on the organ transplant waiting list.Material and Method: 80 ESRD patients who were on the waiting list between 2018 and 2020 and whose panel reactive antibody (PRA) screening and identification test were studied participated in our study. First, the PRA screening test was performed on the patients, and the class I-II identification tests were studied on the patients who were positive for PRA. The Ang-2 level was evaluated by the ELISA method. The relationship between Ang-2 levels and PRA percentages in PRA positive and negative patients was evaluated.Results: A positive correlation was found between anti-HLA antibody and Ang-2 levels in patients with ESRD (class I, p=0.024; class II, p=0.032), and a statistically significant increase in Ang-2 level was found in patients with PRA ≥50% positive (class I, p=0.038) This finding suggests that Ang-2 may have an important role in the progression of chronic renal failure and may be effective in predicting graft survival after transplantation. Conclusions: Further studies will be required to fully elucidate the effect of Ang-2 on renal progression.https://cdn.istanbul.edu.tr/file/JTA6CLJ8T5/9A9841D848344687B3FC6D39CFE7DD95angiopoetin-2anti-hla antibodykidney transplantation |
| spellingShingle | Süleyman Rüştü Oğuz Ayşe Sinangil Demet Kıvanç İzgi Soykan Barlas Hayriye Şentürk Çiftçi Kıymet Güzin Şen Tevfik Ecder Barış Akın EXPRESSION OF ANGIOPOETIN ON THE KIDNEY TRANSPLANT WAITING LIST: A SINGLE-CENTER STUDY Sabiad angiopoetin-2 anti-hla antibody kidney transplantation |
| title | EXPRESSION OF ANGIOPOETIN ON THE KIDNEY TRANSPLANT WAITING LIST: A SINGLE-CENTER STUDY |
| title_full | EXPRESSION OF ANGIOPOETIN ON THE KIDNEY TRANSPLANT WAITING LIST: A SINGLE-CENTER STUDY |
| title_fullStr | EXPRESSION OF ANGIOPOETIN ON THE KIDNEY TRANSPLANT WAITING LIST: A SINGLE-CENTER STUDY |
| title_full_unstemmed | EXPRESSION OF ANGIOPOETIN ON THE KIDNEY TRANSPLANT WAITING LIST: A SINGLE-CENTER STUDY |
| title_short | EXPRESSION OF ANGIOPOETIN ON THE KIDNEY TRANSPLANT WAITING LIST: A SINGLE-CENTER STUDY |
| title_sort | expression of angiopoetin on the kidney transplant waiting list a single center study |
| topic | angiopoetin-2 anti-hla antibody kidney transplantation |
| url | https://cdn.istanbul.edu.tr/file/JTA6CLJ8T5/9A9841D848344687B3FC6D39CFE7DD95 |
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