Altered functional activity and connectivity in Parkinson’s disease with chronic pain: a resting-state fMRI study

Altered functional activity and connectivity in Parkinson’s disease with chronic pain: a resting-state fMRI study

BackgroundChronic pain is a common non-motor symptom of Parkinson’s disease (PD) that significantly impacts patients’ quality of life, but its neural mechanisms remain poorly understood. This study investigated changes in spontaneous neuronal activity and functional connectivity (FC) associated with...

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Bibliographic Details
Main Authors: Erlei Wang, Nan Zou, Jinru Zhang, Yiqing Bao, Yang Ya, Junkang Shen, Yujing Jia, Chengjie Mao, Guohua Fan
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-03-01
Series:Frontiers in Aging Neuroscience
Subjects:
Parkinson’s disease
chronic pain
resting-state fMRI
the amplitude of low-frequency fluctuations
functional connectivity
Online Access:https://www.frontiersin.org/articles/10.3389/fnagi.2025.1499262/full
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