Negative cooperativity regulates ligand activation of DIAPH1 and other diaphanous related formins

Negative cooperativity regulates ligand activation of DIAPH1 and other diaphanous related formins

Abstract DIAPH1 is a member of the family of Diaphanous Related Formins (DRFs) implicated in cell migration and cytokinesis. DRFs are maintained in an autoinhibited state by the intramolecular association between diaphanous inhibitory (DID) and diaphanous autoregulatory (DAD) domains. Actin polymeri...

Full description

Saved in:
Bibliographic Details
Main Authors: G. G. Theophall, A. Premo, S. Reverdatto, E. Omojowolo, P. Nazarian, D. S. Burz, R. Ramasamy, A. M. Schmidt, A. Shekhtman
Format: Article
Language:English
Published: Nature Portfolio 2025-05-01
Series:Communications Biology
Online Access:https://doi.org/10.1038/s42003-025-08222-5
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items

Similar Items