Neoplastic and Non-Neoplastic Proliferative Mammary Gland Lesions in Female and Male Guinea Pigs: Histological and Immunohistochemical Characterization
Mammary tumors occur in female and male guinea pigs. However, published data on their histology and sex predispositions are limited. Histologically, we examined proliferative mammary lesions of 69 female and 48 male pet guinea pigs. Lobular hyperplasia was observed only in females (<i>n</i&...
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| author | Sandra Schöniger Claudia Schandelmaier Heike Aupperle-Lellbach Christina Koppel Qian Zhang Hans-Ulrich Schildhaus |
| author_facet | Sandra Schöniger Claudia Schandelmaier Heike Aupperle-Lellbach Christina Koppel Qian Zhang Hans-Ulrich Schildhaus |
| author_sort | Sandra Schöniger |
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| description | Mammary tumors occur in female and male guinea pigs. However, published data on their histology and sex predispositions are limited. Histologically, we examined proliferative mammary lesions of 69 female and 48 male pet guinea pigs. Lobular hyperplasia was observed only in females (<i>n</i> = 50). Benign tumors included simple adenomas (<i>n</i> = 20), adenolipomas (<i>n</i> = 3) and intraductal papillary adenomas (<i>n</i> = 5). All except two intraductal papillary adenomas occurred in females. Most malignancies were tubulopapillary and solid carcinomas (<i>n</i> = 54), and intraductal papillary carcinomas (<i>n</i> = 13). These were diagnosed more frequently in male (<i>n</i> = 41) than in female (<i>n</i> = 26) guinea pigs. The carcinomas of males had higher mitotic counts than those of females (<i>p</i> = 0.05). Three carcinosarcomas developed in adenolipoma, and one arose in adenoma. Results show that the mammary tumor classification of dogs and cats can be applied to guinea pigs. However, some tumors (adenolipoma, metaplastic carcinoma) are unique to guinea pigs and shared with laboratory rodents and humans, respectively. Benign tumors may undergo malignant progression. Male guinea pigs appear predisposed to ductal-associated and malignant tumors. Data suggest that male guinea pigs represent an animal model for human male breast cancer. |
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| spelling | doaj-art-db60815e52204381b2b85cc52a8d95e52025-08-20T02:23:08ZengMDPI AGAnimals2076-26152025-05-011511157310.3390/ani15111573Neoplastic and Non-Neoplastic Proliferative Mammary Gland Lesions in Female and Male Guinea Pigs: Histological and Immunohistochemical CharacterizationSandra Schöniger0Claudia Schandelmaier1Heike Aupperle-Lellbach2Christina Koppel3Qian Zhang4Hans-Ulrich Schildhaus5Discovery Life Sciences Biomarker Services GmbH, Germaniastrasse 7, 34119 Kassel, GermanyLaboklin GmbH & Co. KG, Laboratory for Clinical Diagnostics, 97688 Bad Kissingen, GermanyLaboklin GmbH & Co. KG, Laboratory for Clinical Diagnostics, 97688 Bad Kissingen, GermanyDiscovery Life Sciences Biomarker Services GmbH, Germaniastrasse 7, 34119 Kassel, GermanyInstitute of Anatomy, Experimental Neurobiology, Goethe-University, Theodor-Stern-Kai 7, 60590 Frankfurt am Main, GermanyDiscovery Life Sciences Biomarker Services GmbH, Germaniastrasse 7, 34119 Kassel, GermanyMammary tumors occur in female and male guinea pigs. However, published data on their histology and sex predispositions are limited. Histologically, we examined proliferative mammary lesions of 69 female and 48 male pet guinea pigs. Lobular hyperplasia was observed only in females (<i>n</i> = 50). Benign tumors included simple adenomas (<i>n</i> = 20), adenolipomas (<i>n</i> = 3) and intraductal papillary adenomas (<i>n</i> = 5). All except two intraductal papillary adenomas occurred in females. Most malignancies were tubulopapillary and solid carcinomas (<i>n</i> = 54), and intraductal papillary carcinomas (<i>n</i> = 13). These were diagnosed more frequently in male (<i>n</i> = 41) than in female (<i>n</i> = 26) guinea pigs. The carcinomas of males had higher mitotic counts than those of females (<i>p</i> = 0.05). Three carcinosarcomas developed in adenolipoma, and one arose in adenoma. Results show that the mammary tumor classification of dogs and cats can be applied to guinea pigs. However, some tumors (adenolipoma, metaplastic carcinoma) are unique to guinea pigs and shared with laboratory rodents and humans, respectively. Benign tumors may undergo malignant progression. Male guinea pigs appear predisposed to ductal-associated and malignant tumors. Data suggest that male guinea pigs represent an animal model for human male breast cancer.https://www.mdpi.com/2076-2615/15/11/1573<i>Cavia porcellus</i>guinea pigpetproliferative mammary lesionsmammary tumorshistopathology |
| spellingShingle | Sandra Schöniger Claudia Schandelmaier Heike Aupperle-Lellbach Christina Koppel Qian Zhang Hans-Ulrich Schildhaus Neoplastic and Non-Neoplastic Proliferative Mammary Gland Lesions in Female and Male Guinea Pigs: Histological and Immunohistochemical Characterization Animals <i>Cavia porcellus</i> guinea pig pet proliferative mammary lesions mammary tumors histopathology |
| title | Neoplastic and Non-Neoplastic Proliferative Mammary Gland Lesions in Female and Male Guinea Pigs: Histological and Immunohistochemical Characterization |
| title_full | Neoplastic and Non-Neoplastic Proliferative Mammary Gland Lesions in Female and Male Guinea Pigs: Histological and Immunohistochemical Characterization |
| title_fullStr | Neoplastic and Non-Neoplastic Proliferative Mammary Gland Lesions in Female and Male Guinea Pigs: Histological and Immunohistochemical Characterization |
| title_full_unstemmed | Neoplastic and Non-Neoplastic Proliferative Mammary Gland Lesions in Female and Male Guinea Pigs: Histological and Immunohistochemical Characterization |
| title_short | Neoplastic and Non-Neoplastic Proliferative Mammary Gland Lesions in Female and Male Guinea Pigs: Histological and Immunohistochemical Characterization |
| title_sort | neoplastic and non neoplastic proliferative mammary gland lesions in female and male guinea pigs histological and immunohistochemical characterization |
| topic | <i>Cavia porcellus</i> guinea pig pet proliferative mammary lesions mammary tumors histopathology |
| url | https://www.mdpi.com/2076-2615/15/11/1573 |
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