Causal relationships of anxiety, depression and neuroticism with recurrent spontaneous abortion: a Mendelian randomization analysis
Objective To explore the causal relationships of anxiety, depression and neuroticism with recurrent spontaneous abortion (RSA). Methods Genome-wide association study (GWAS) data were used to extract single nucleotide polymorphisms (SNPs) closely related to anxiety, depression and neuroticism as in...
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Editorial Office of Journal of Army Medical University
2025-02-01
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| Series: | 陆军军医大学学报 |
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| Online Access: | https://aammt.tmmu.edu.cn/html/202405107.html |
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| author | YUAN Hao YUAN Hao LI Xiao LI Xiao |
| author_facet | YUAN Hao YUAN Hao LI Xiao LI Xiao |
| author_sort | YUAN Hao |
| collection | DOAJ |
| description | Objective To explore the causal relationships of anxiety, depression and neuroticism with recurrent spontaneous abortion (RSA). Methods Genome-wide association study (GWAS) data were used to extract single nucleotide polymorphisms (SNPs) closely related to anxiety, depression and neuroticism as instrumental variables (IVs). Inverse variance weighting (IVW), weighted median estimator (WME), weighted mode (WM) and Mendelian randomization (MR)-Egger regression were employed for MR analysis to evaluate the causal effects of anxiety, depression and neuroticism with RSA, and to analyze heterogeneity, gene pleiotropy and sensitivity. Results A total of 46 SNPs were extracted from GWAS data as IVs (5 anxiety SNPs, 9 depression SNPs, and 32 neuroticism SNPs). IVW, WME, WM and MR-Egger regression analysis revealed that the odds ratio (OR) and 95% confidence interval (CI) of anxiety data were 1.07 (0.86-1.32), 1.10 ( 0.85-1.43), 1.14 (0.81-1.59) and 1.18 (0.53-2.61); those of depression data were 1.11 (0.93-1.32), 1.05 (0.83-1.32), 0.96 (0.67-1.38) and 0.57 (0.25-1.31); those of neuroticism data were 1.01 (0.75-1.36), 1.07 (0.73-1.56), 1.02 (0.49-2.12) and 2.40 (0.46-12.44), but none of the above causal analyses were statistically significant (all P>0.05). After reliability analysis, the Cochran's Q test for heterogeneity evaluation was not significant (P>0.05), the MR-Egger regression intercepts for gene pleiotropy evaluation were all close to 0 (P>0.05), and the sensitivity evaluation "Leave-one-out" test also shows that the combined causal effect values are similar. Conclusion There dose not exist causal relationships of anxiety, depression and neuroticism with RSA. The reliability test shows that the results are relatively robust.
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| format | Article |
| id | doaj-art-db5d8ea7357a4c03b22a96b9df8fdb10 |
| institution | OA Journals |
| issn | 2097-0927 |
| language | zho |
| publishDate | 2025-02-01 |
| publisher | Editorial Office of Journal of Army Medical University |
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| series | 陆军军医大学学报 |
| spelling | doaj-art-db5d8ea7357a4c03b22a96b9df8fdb102025-08-20T02:04:11ZzhoEditorial Office of Journal of Army Medical University陆军军医大学学报2097-09272025-02-0147437838410.16016/j.2097-0927.202405107Causal relationships of anxiety, depression and neuroticism with recurrent spontaneous abortion: a Mendelian randomization analysisYUAN Hao0YUAN Hao1LI Xiao2LI Xiao3Departmental of Reproductive Medicine， First Affiliated Hospital of Henan University of Chinese Medicine， Zhengzhou， Henanthe First Clinical Medical School of Henan University of Chinese Medicine， Zhengzhou， Henan， ChinaDepartmental of Reproductive Medicine， First Affiliated Hospital of Henan University of Chinese Medicine， Zhengzhou， Henan the First Clinical Medical School of Henan University of Chinese Medicine， Zhengzhou， Henan， ChinaObjective To explore the causal relationships of anxiety, depression and neuroticism with recurrent spontaneous abortion (RSA). Methods Genome-wide association study (GWAS) data were used to extract single nucleotide polymorphisms (SNPs) closely related to anxiety, depression and neuroticism as instrumental variables (IVs). Inverse variance weighting (IVW), weighted median estimator (WME), weighted mode (WM) and Mendelian randomization (MR)-Egger regression were employed for MR analysis to evaluate the causal effects of anxiety, depression and neuroticism with RSA, and to analyze heterogeneity, gene pleiotropy and sensitivity. Results A total of 46 SNPs were extracted from GWAS data as IVs (5 anxiety SNPs, 9 depression SNPs, and 32 neuroticism SNPs). IVW, WME, WM and MR-Egger regression analysis revealed that the odds ratio (OR) and 95% confidence interval (CI) of anxiety data were 1.07 (0.86-1.32), 1.10 ( 0.85-1.43), 1.14 (0.81-1.59) and 1.18 (0.53-2.61); those of depression data were 1.11 (0.93-1.32), 1.05 (0.83-1.32), 0.96 (0.67-1.38) and 0.57 (0.25-1.31); those of neuroticism data were 1.01 (0.75-1.36), 1.07 (0.73-1.56), 1.02 (0.49-2.12) and 2.40 (0.46-12.44), but none of the above causal analyses were statistically significant (all P>0.05). After reliability analysis, the Cochran's Q test for heterogeneity evaluation was not significant (P>0.05), the MR-Egger regression intercepts for gene pleiotropy evaluation were all close to 0 (P>0.05), and the sensitivity evaluation "Leave-one-out" test also shows that the combined causal effect values are similar. Conclusion There dose not exist causal relationships of anxiety, depression and neuroticism with RSA. The reliability test shows that the results are relatively robust. https://aammt.tmmu.edu.cn/html/202405107.htmlnegative emotionrecurrent spontaneous abortionmendelian randomization analysis |
| spellingShingle | YUAN Hao YUAN Hao LI Xiao LI Xiao Causal relationships of anxiety, depression and neuroticism with recurrent spontaneous abortion: a Mendelian randomization analysis 陆军军医大学学报 negative emotion recurrent spontaneous abortion mendelian randomization analysis |
| title | Causal relationships of anxiety, depression and neuroticism with recurrent spontaneous abortion: a Mendelian randomization analysis |
| title_full | Causal relationships of anxiety, depression and neuroticism with recurrent spontaneous abortion: a Mendelian randomization analysis |
| title_fullStr | Causal relationships of anxiety, depression and neuroticism with recurrent spontaneous abortion: a Mendelian randomization analysis |
| title_full_unstemmed | Causal relationships of anxiety, depression and neuroticism with recurrent spontaneous abortion: a Mendelian randomization analysis |
| title_short | Causal relationships of anxiety, depression and neuroticism with recurrent spontaneous abortion: a Mendelian randomization analysis |
| title_sort | causal relationships of anxiety depression and neuroticism with recurrent spontaneous abortion a mendelian randomization analysis |
| topic | negative emotion recurrent spontaneous abortion mendelian randomization analysis |
| url | https://aammt.tmmu.edu.cn/html/202405107.html |
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