Graves' Disease as a Manifestation of Immune Reconstitution in HIV-Infected Individuals after Initiation of Highly Active Antiretroviral Therapy
Graves' disease after the initiation of highly active antiretroviral therapy (HAART) in certain HIV-1-infected individuals has been described as an immune reconstitution inflammatory syndrome (IRIS). This phenomenon should be suspected in individuals who present with clinical deterioration and...
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2011-01-01
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| Series: | AIDS Research and Treatment |
| Online Access: | http://dx.doi.org/10.1155/2011/743597 |
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| _version_ | 1832556575481397248 |
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| author | Samad Rasul Robert Delapenha Faria Farhat Jhansi Gajjala Syeda Mehreen Zahra |
| author_facet | Samad Rasul Robert Delapenha Faria Farhat Jhansi Gajjala Syeda Mehreen Zahra |
| author_sort | Samad Rasul |
| collection | DOAJ |
| description | Graves' disease after the initiation of highly active antiretroviral therapy (HAART) in certain HIV-1-infected individuals has been described as an immune reconstitution inflammatory syndrome (IRIS). This phenomenon should be suspected in individuals who present with clinical deterioration and a presentation suggestive of hyperthyroidism despite good virological and immunological response to HAART. Signs and symptoms of hyperthyroidism may be discrete or overt and typically develop 8–33 months after initiating therapy. One to two percent of HIV-infected patients can present with overt thyroid disease. Relatively few cases of Graves' IRIS have been reported in the literature to date. We describe four cases of Graves' IRIS in HIV-infected patients who were started on HAART therapy. |
| format | Article |
| id | doaj-art-db5c0ca3a2f4472bb4116424f25970b9 |
| institution | Kabale University |
| issn | 2090-1240 2090-1259 |
| language | English |
| publishDate | 2011-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | AIDS Research and Treatment |
| spelling | doaj-art-db5c0ca3a2f4472bb4116424f25970b92025-02-03T05:45:05ZengWileyAIDS Research and Treatment2090-12402090-12592011-01-01201110.1155/2011/743597743597Graves' Disease as a Manifestation of Immune Reconstitution in HIV-Infected Individuals after Initiation of Highly Active Antiretroviral TherapySamad Rasul0Robert Delapenha1Faria Farhat2Jhansi Gajjala3Syeda Mehreen Zahra4Division of Infectious Diseases, Department of Internal Medicine, Howard University Hospital, Washington DC, USADivision of Infectious Diseases, Department of Internal Medicine, Howard University Hospital, Washington DC, USADivision of Infectious Diseases, Department of Internal Medicine, Howard University Hospital, Washington DC, USADivision of Infectious Diseases, Department of Internal Medicine, Howard University Hospital, Washington DC, USADivision of Infectious Diseases, Department of Internal Medicine, Howard University Hospital, Washington DC, USAGraves' disease after the initiation of highly active antiretroviral therapy (HAART) in certain HIV-1-infected individuals has been described as an immune reconstitution inflammatory syndrome (IRIS). This phenomenon should be suspected in individuals who present with clinical deterioration and a presentation suggestive of hyperthyroidism despite good virological and immunological response to HAART. Signs and symptoms of hyperthyroidism may be discrete or overt and typically develop 8–33 months after initiating therapy. One to two percent of HIV-infected patients can present with overt thyroid disease. Relatively few cases of Graves' IRIS have been reported in the literature to date. We describe four cases of Graves' IRIS in HIV-infected patients who were started on HAART therapy.http://dx.doi.org/10.1155/2011/743597 |
| spellingShingle | Samad Rasul Robert Delapenha Faria Farhat Jhansi Gajjala Syeda Mehreen Zahra Graves' Disease as a Manifestation of Immune Reconstitution in HIV-Infected Individuals after Initiation of Highly Active Antiretroviral Therapy AIDS Research and Treatment |
| title | Graves' Disease as a Manifestation of Immune Reconstitution in HIV-Infected Individuals after Initiation of Highly Active Antiretroviral Therapy |
| title_full | Graves' Disease as a Manifestation of Immune Reconstitution in HIV-Infected Individuals after Initiation of Highly Active Antiretroviral Therapy |
| title_fullStr | Graves' Disease as a Manifestation of Immune Reconstitution in HIV-Infected Individuals after Initiation of Highly Active Antiretroviral Therapy |
| title_full_unstemmed | Graves' Disease as a Manifestation of Immune Reconstitution in HIV-Infected Individuals after Initiation of Highly Active Antiretroviral Therapy |
| title_short | Graves' Disease as a Manifestation of Immune Reconstitution in HIV-Infected Individuals after Initiation of Highly Active Antiretroviral Therapy |
| title_sort | graves disease as a manifestation of immune reconstitution in hiv infected individuals after initiation of highly active antiretroviral therapy |
| url | http://dx.doi.org/10.1155/2011/743597 |
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