Association between gastroesophageal reflux disease and coronary atherosclerosis.
<h4>Background and aim</h4>Gastroesophageal reflux disease (GERD) typically presents with symptoms of heartburn and acid regurgitation but occasionally manifests as atypical chest pain. Coronary artery disease (CAD) and GERD share some risk factors, such as smoking and obesity. The aims...
Saved in:
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2022-01-01
|
| Series: | PLoS ONE |
| Online Access: | https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0267053&type=printable |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850235575419797504 |
|---|---|
| author | Ji Hyun Song Young Sun Kim Su-Yeon Choi Sun Young Yang |
| author_facet | Ji Hyun Song Young Sun Kim Su-Yeon Choi Sun Young Yang |
| author_sort | Ji Hyun Song |
| collection | DOAJ |
| description | <h4>Background and aim</h4>Gastroesophageal reflux disease (GERD) typically presents with symptoms of heartburn and acid regurgitation but occasionally manifests as atypical chest pain. Coronary artery disease (CAD) and GERD share some risk factors, such as smoking and obesity. The aims of this study were to evaluate the association between GERD and coronary atherosclerosis and to assess the risk factors for coronary atherosclerosis in GERD patients.<h4>Methods</h4>A total of 16616 subjects who underwent upper gastrointestinal endoscopy from 2003 to 2017 and a cardiac computed tomography (CT) scan within one year were included in this study. Coronary atherosclerosis was evaluated by the coronary artery calcium score (CACS). The severity of GERD was evaluated based on endoscopic findings using the Los Angeles classification.<h4>Results</h4>The proportion of high CACSs (≥100) increased significantly in subjects with severe GERD (p = 0.008). However, the presence of a high CACS did not increase the risk of GERD (OR = 1.007, 95% CI 0.857-1.182), nor did that of GERD increase the risk of a high CACS (OR = 1.018, 95% CI 0.865-1.198). The risk factors for a high CACS in GERD patients included age (OR = 1.087, 95% CI 1.066-1.109), male sex (OR = 5.645, 95% CI 2.561-12.446), hypertension (OR = 1.800, 95% CI 1.325-2.446), and hypercholesterolemia (OR = 1.684, 95% CI 1.213-2.338).<h4>Conclusions</h4>Although the presence of a high CACS did not increase the risk of GERD or vice versa, the proportion of high CACSs was significantly higher in subjects with severe GERD. Therefore, it might be helpful to assess the CACS in GERD patients with multiple risk factors. |
| format | Article |
| id | doaj-art-db59fb62ecd94ac2bec12652fa1bc70c |
| institution | OA Journals |
| issn | 1932-6203 |
| language | English |
| publishDate | 2022-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj-art-db59fb62ecd94ac2bec12652fa1bc70c2025-08-20T02:02:12ZengPublic Library of Science (PLoS)PLoS ONE1932-62032022-01-01175e026705310.1371/journal.pone.0267053Association between gastroesophageal reflux disease and coronary atherosclerosis.Ji Hyun SongYoung Sun KimSu-Yeon ChoiSun Young Yang<h4>Background and aim</h4>Gastroesophageal reflux disease (GERD) typically presents with symptoms of heartburn and acid regurgitation but occasionally manifests as atypical chest pain. Coronary artery disease (CAD) and GERD share some risk factors, such as smoking and obesity. The aims of this study were to evaluate the association between GERD and coronary atherosclerosis and to assess the risk factors for coronary atherosclerosis in GERD patients.<h4>Methods</h4>A total of 16616 subjects who underwent upper gastrointestinal endoscopy from 2003 to 2017 and a cardiac computed tomography (CT) scan within one year were included in this study. Coronary atherosclerosis was evaluated by the coronary artery calcium score (CACS). The severity of GERD was evaluated based on endoscopic findings using the Los Angeles classification.<h4>Results</h4>The proportion of high CACSs (≥100) increased significantly in subjects with severe GERD (p = 0.008). However, the presence of a high CACS did not increase the risk of GERD (OR = 1.007, 95% CI 0.857-1.182), nor did that of GERD increase the risk of a high CACS (OR = 1.018, 95% CI 0.865-1.198). The risk factors for a high CACS in GERD patients included age (OR = 1.087, 95% CI 1.066-1.109), male sex (OR = 5.645, 95% CI 2.561-12.446), hypertension (OR = 1.800, 95% CI 1.325-2.446), and hypercholesterolemia (OR = 1.684, 95% CI 1.213-2.338).<h4>Conclusions</h4>Although the presence of a high CACS did not increase the risk of GERD or vice versa, the proportion of high CACSs was significantly higher in subjects with severe GERD. Therefore, it might be helpful to assess the CACS in GERD patients with multiple risk factors.https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0267053&type=printable |
| spellingShingle | Ji Hyun Song Young Sun Kim Su-Yeon Choi Sun Young Yang Association between gastroesophageal reflux disease and coronary atherosclerosis. PLoS ONE |
| title | Association between gastroesophageal reflux disease and coronary atherosclerosis. |
| title_full | Association between gastroesophageal reflux disease and coronary atherosclerosis. |
| title_fullStr | Association between gastroesophageal reflux disease and coronary atherosclerosis. |
| title_full_unstemmed | Association between gastroesophageal reflux disease and coronary atherosclerosis. |
| title_short | Association between gastroesophageal reflux disease and coronary atherosclerosis. |
| title_sort | association between gastroesophageal reflux disease and coronary atherosclerosis |
| url | https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0267053&type=printable |
| work_keys_str_mv | AT jihyunsong associationbetweengastroesophagealrefluxdiseaseandcoronaryatherosclerosis AT youngsunkim associationbetweengastroesophagealrefluxdiseaseandcoronaryatherosclerosis AT suyeonchoi associationbetweengastroesophagealrefluxdiseaseandcoronaryatherosclerosis AT sunyoungyang associationbetweengastroesophagealrefluxdiseaseandcoronaryatherosclerosis |