Transcriptomic Profiling of <i>Misgurnus anguillicaudatus</i> Reveals the Anti-Inflammatory Action of <i>Lonicera japonica</i> Extract in Response to Lipopolysaccharide Challenge
Honeysuckle, derived from the dried flower buds or blossoms of <i>Lonicera japonica</i> Thunb, is a traditional Chinese medicine known for its properties in eliminating heat and toxins, reducing inflammation, and alleviating swelling. In this study, we investigated the potential therapeu...
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MDPI AG
2025-07-01
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| author | Yue Zhao Chen Wang Qiuning Liu |
| author_facet | Yue Zhao Chen Wang Qiuning Liu |
| author_sort | Yue Zhao |
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| description | Honeysuckle, derived from the dried flower buds or blossoms of <i>Lonicera japonica</i> Thunb, is a traditional Chinese medicine known for its properties in eliminating heat and toxins, reducing inflammation, and alleviating swelling. In this study, we investigated the potential therapeutic and preventive benefits of <i>L. japonica</i> extract on inflammatory diseases induced by lipopolysaccharide (LPS) using <i>Misgurnus anguillicaudatus</i> as a model organism. The fish were fed a diet supplemented with <i>L. japonica</i> extract, followed by LPS injection to induce inflammation. We then analyzed the transcriptional profile to identify differentially expressed genes (DEGs). A total of 6611 DEGs were identified through comprehensive analysis, including Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analyses. Our results revealed significant enrichment of DEGs in pathways associated with proteasome function, immune system regulation, and infectious disease response. These findings suggest a strong correlation between <i>L. japonica</i> and immune defense mechanisms, providing valuable insights into the potential anti-inflammatory effects of this plant, particularly in the context of LPS-induced inflammation. This study highlights the potential use of <i>L. japonica</i> in treating inflammatory diseases and underscores its role in immune regulation. |
| format | Article |
| id | doaj-art-db44071f83a94bc5b77404e968402006 |
| institution | Kabale University |
| issn | 2410-3888 |
| language | English |
| publishDate | 2025-07-01 |
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| record_format | Article |
| series | Fishes |
| spelling | doaj-art-db44071f83a94bc5b77404e9684020062025-08-20T03:36:19ZengMDPI AGFishes2410-38882025-07-0110733310.3390/fishes10070333Transcriptomic Profiling of <i>Misgurnus anguillicaudatus</i> Reveals the Anti-Inflammatory Action of <i>Lonicera japonica</i> Extract in Response to Lipopolysaccharide ChallengeYue Zhao0Chen Wang1Qiuning Liu2School of Biological and Environmental Engineering, Chaohu University, Hefei 238024, ChinaChaohu Regional Collaborative Technology Service Center for Rural Revitalization, Chaohu University, Hefei 238024, ChinaSchool of Wetlands, Yancheng Teachers University, Yancheng 224007, ChinaHoneysuckle, derived from the dried flower buds or blossoms of <i>Lonicera japonica</i> Thunb, is a traditional Chinese medicine known for its properties in eliminating heat and toxins, reducing inflammation, and alleviating swelling. In this study, we investigated the potential therapeutic and preventive benefits of <i>L. japonica</i> extract on inflammatory diseases induced by lipopolysaccharide (LPS) using <i>Misgurnus anguillicaudatus</i> as a model organism. The fish were fed a diet supplemented with <i>L. japonica</i> extract, followed by LPS injection to induce inflammation. We then analyzed the transcriptional profile to identify differentially expressed genes (DEGs). A total of 6611 DEGs were identified through comprehensive analysis, including Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analyses. Our results revealed significant enrichment of DEGs in pathways associated with proteasome function, immune system regulation, and infectious disease response. These findings suggest a strong correlation between <i>L. japonica</i> and immune defense mechanisms, providing valuable insights into the potential anti-inflammatory effects of this plant, particularly in the context of LPS-induced inflammation. This study highlights the potential use of <i>L. japonica</i> in treating inflammatory diseases and underscores its role in immune regulation.https://www.mdpi.com/2410-3888/10/7/333<i>Lonicera japonica</i> Thunbtranscriptomicslipopolysaccharideinflammation |
| spellingShingle | Yue Zhao Chen Wang Qiuning Liu Transcriptomic Profiling of <i>Misgurnus anguillicaudatus</i> Reveals the Anti-Inflammatory Action of <i>Lonicera japonica</i> Extract in Response to Lipopolysaccharide Challenge Fishes <i>Lonicera japonica</i> Thunb transcriptomics lipopolysaccharide inflammation |
| title | Transcriptomic Profiling of <i>Misgurnus anguillicaudatus</i> Reveals the Anti-Inflammatory Action of <i>Lonicera japonica</i> Extract in Response to Lipopolysaccharide Challenge |
| title_full | Transcriptomic Profiling of <i>Misgurnus anguillicaudatus</i> Reveals the Anti-Inflammatory Action of <i>Lonicera japonica</i> Extract in Response to Lipopolysaccharide Challenge |
| title_fullStr | Transcriptomic Profiling of <i>Misgurnus anguillicaudatus</i> Reveals the Anti-Inflammatory Action of <i>Lonicera japonica</i> Extract in Response to Lipopolysaccharide Challenge |
| title_full_unstemmed | Transcriptomic Profiling of <i>Misgurnus anguillicaudatus</i> Reveals the Anti-Inflammatory Action of <i>Lonicera japonica</i> Extract in Response to Lipopolysaccharide Challenge |
| title_short | Transcriptomic Profiling of <i>Misgurnus anguillicaudatus</i> Reveals the Anti-Inflammatory Action of <i>Lonicera japonica</i> Extract in Response to Lipopolysaccharide Challenge |
| title_sort | transcriptomic profiling of i misgurnus anguillicaudatus i reveals the anti inflammatory action of i lonicera japonica i extract in response to lipopolysaccharide challenge |
| topic | <i>Lonicera japonica</i> Thunb transcriptomics lipopolysaccharide inflammation |
| url | https://www.mdpi.com/2410-3888/10/7/333 |
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