Features of Intracellular Matrix State during Development and Formation of COPD Clinical Phenotypes
The objective: to evaluate state of extracellular matrix markers and their tissue inhibitors during development and formation of clinical phenotypes of COPD, in patients facing the high risk of developing exacerbations.Subjects and Methods. 96 COPD patients (73% men and 27% women) were examined. Pat...
Saved in:
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | Russian |
| Published: |
New Terra Publishing House
2024-10-01
|
| Series: | Туберкулез и болезни лёгких |
| Subjects: | |
| Online Access: | https://www.tibl-journal.com/jour/article/view/1833 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849771234561097728 |
|---|---|
| author | T. V. Tayutina S. V. Shlyk D. A. Kudlay S. V. Smerdin L. A. Shovkun E. A. Kizhevatova N. Yu. Nikolenko E. D. Kampos |
| author_facet | T. V. Tayutina S. V. Shlyk D. A. Kudlay S. V. Smerdin L. A. Shovkun E. A. Kizhevatova N. Yu. Nikolenko E. D. Kampos |
| author_sort | T. V. Tayutina |
| collection | DOAJ |
| description | The objective: to evaluate state of extracellular matrix markers and their tissue inhibitors during development and formation of clinical phenotypes of COPD, in patients facing the high risk of developing exacerbations.Subjects and Methods. 96 COPD patients (73% men and 27% women) were examined. Patients were randomized into the following groups: Group 1 included 40 COPD patients with bronchitis phenotype; Group 2 included 38 patients with emphysema phenotype; and Control Group consisted of 18 practically healthy subjects. All patients underwent a comprehensive clinical and laboratory examination. Levels of matrix metalloproteinases (total MMP-9 and MMP-2) and their tissue inhibitors TIMMP1 and TIMMP2 were determined by ELISA.Results. The development of COPD, regardless of the clinical phenotype of the disease, is accompanied by pronounced expression of extracellular matrix markers MMP-9 and MMP-2. Regardless of the COPD clinical phenotype, elevated activity of metalloproteinases is accompanied by inhibition of production of TIMMP2 and dysfunction of the MMP-9/TIMMP1 antiprotease system. In COPD patients with MMP-2 level of 214 ng/ml, the formation of bronchitis phenotype can be predicted, while with MMP-2 level of 214 ng/ml or more, the formation of emphysema phenotype can be predicted. |
| format | Article |
| id | doaj-art-db3d12eaefec4a76836622707ea5703e |
| institution | DOAJ |
| issn | 2075-1230 2542-1506 |
| language | Russian |
| publishDate | 2024-10-01 |
| publisher | New Terra Publishing House |
| record_format | Article |
| series | Туберкулез и болезни лёгких |
| spelling | doaj-art-db3d12eaefec4a76836622707ea5703e2025-08-20T03:02:41ZrusNew Terra Publishing HouseТуберкулез и болезни лёгких2075-12302542-15062024-10-011024849210.58838/2075-1230-2024-102-4-84-921828Features of Intracellular Matrix State during Development and Formation of COPD Clinical PhenotypesT. V. Tayutina0S. V. Shlyk1D. A. Kudlay2S. V. Smerdin3L. A. Shovkun4E. A. Kizhevatova5N. Yu. Nikolenko6E. D. Kampos7Rostov State Medical University, Russian Ministry of HealthRostov State Medical University, Russian Ministry of HealthI.M. Sechenov First Moscow State Medical University (Sechenov University), Russian Ministry of Health; Lomonosov Moscow State University; Immunology Research Institute by Federal Medical Biological AgencyMoscow Regional Clinical TB Dispensary; M.F. Vladimirsky Moscow Regional Research Clinical InstituteRostov State Medical University, Russian Ministry of HealthRostov State Medical University, Russian Ministry of HealthMoscow Research and Clinical Center for Tuberculosis Control, Moscow Government Department of HealthRostov State Medical University, Russian Ministry of HealthThe objective: to evaluate state of extracellular matrix markers and their tissue inhibitors during development and formation of clinical phenotypes of COPD, in patients facing the high risk of developing exacerbations.Subjects and Methods. 96 COPD patients (73% men and 27% women) were examined. Patients were randomized into the following groups: Group 1 included 40 COPD patients with bronchitis phenotype; Group 2 included 38 patients with emphysema phenotype; and Control Group consisted of 18 practically healthy subjects. All patients underwent a comprehensive clinical and laboratory examination. Levels of matrix metalloproteinases (total MMP-9 and MMP-2) and their tissue inhibitors TIMMP1 and TIMMP2 were determined by ELISA.Results. The development of COPD, regardless of the clinical phenotype of the disease, is accompanied by pronounced expression of extracellular matrix markers MMP-9 and MMP-2. Regardless of the COPD clinical phenotype, elevated activity of metalloproteinases is accompanied by inhibition of production of TIMMP2 and dysfunction of the MMP-9/TIMMP1 antiprotease system. In COPD patients with MMP-2 level of 214 ng/ml, the formation of bronchitis phenotype can be predicted, while with MMP-2 level of 214 ng/ml or more, the formation of emphysema phenotype can be predicted.https://www.tibl-journal.com/jour/article/view/1833chronic obstructive pulmonary diseaseextracellular matrix markersemphysema copd phenotypebronchitis copd phenotypeprotease-antiprotease system |
| spellingShingle | T. V. Tayutina S. V. Shlyk D. A. Kudlay S. V. Smerdin L. A. Shovkun E. A. Kizhevatova N. Yu. Nikolenko E. D. Kampos Features of Intracellular Matrix State during Development and Formation of COPD Clinical Phenotypes Туберкулез и болезни лёгких chronic obstructive pulmonary disease extracellular matrix markers emphysema copd phenotype bronchitis copd phenotype protease-antiprotease system |
| title | Features of Intracellular Matrix State during Development and Formation of COPD Clinical Phenotypes |
| title_full | Features of Intracellular Matrix State during Development and Formation of COPD Clinical Phenotypes |
| title_fullStr | Features of Intracellular Matrix State during Development and Formation of COPD Clinical Phenotypes |
| title_full_unstemmed | Features of Intracellular Matrix State during Development and Formation of COPD Clinical Phenotypes |
| title_short | Features of Intracellular Matrix State during Development and Formation of COPD Clinical Phenotypes |
| title_sort | features of intracellular matrix state during development and formation of copd clinical phenotypes |
| topic | chronic obstructive pulmonary disease extracellular matrix markers emphysema copd phenotype bronchitis copd phenotype protease-antiprotease system |
| url | https://www.tibl-journal.com/jour/article/view/1833 |
| work_keys_str_mv | AT tvtayutina featuresofintracellularmatrixstateduringdevelopmentandformationofcopdclinicalphenotypes AT svshlyk featuresofintracellularmatrixstateduringdevelopmentandformationofcopdclinicalphenotypes AT dakudlay featuresofintracellularmatrixstateduringdevelopmentandformationofcopdclinicalphenotypes AT svsmerdin featuresofintracellularmatrixstateduringdevelopmentandformationofcopdclinicalphenotypes AT lashovkun featuresofintracellularmatrixstateduringdevelopmentandformationofcopdclinicalphenotypes AT eakizhevatova featuresofintracellularmatrixstateduringdevelopmentandformationofcopdclinicalphenotypes AT nyunikolenko featuresofintracellularmatrixstateduringdevelopmentandformationofcopdclinicalphenotypes AT edkampos featuresofintracellularmatrixstateduringdevelopmentandformationofcopdclinicalphenotypes |