Effects of Dietary Milled Seed Mixture on Fatty Acid Status and Inflammatory Markers in Patients on Hemodialysis
Background. Plant seeds have gained interest for their health benefits due to their fatty acid content. The objective of this study was to determine the effects of dietary consumption of milled sesame/pumpkin/flax seed mixture on glycemic control, serum lipids, phospholipid fatty acid status, and in...
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| Format: | Article |
| Language: | English |
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Wiley
2014-01-01
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| Series: | The Scientific World Journal |
| Online Access: | http://dx.doi.org/10.1155/2014/563576 |
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| author | Danijela Ristic-Medic Gordana Perunicic-Pekovic Zorica Rasic-Milutinovic Marija Takic Tamara Popovic Aleksandra Arsic Marija Glibetic |
| author_facet | Danijela Ristic-Medic Gordana Perunicic-Pekovic Zorica Rasic-Milutinovic Marija Takic Tamara Popovic Aleksandra Arsic Marija Glibetic |
| author_sort | Danijela Ristic-Medic |
| collection | DOAJ |
| description | Background. Plant seeds have gained interest for their health benefits due to their fatty acid content. The objective of this study was to determine the effects of dietary consumption of milled sesame/pumpkin/flax seed mixture on glycemic control, serum lipids, phospholipid fatty acid status, and inflammatory factors in patients on hemodialysis. Methods. Thirty patients with well nutrition status (18 male, 12 female) were enrolled in the study. Participants consumed 30 g of milled sesame/pumpkin/flax (6 g/6 g/18 g, resp.) seeds mixture added to their habitual diet. Results. Total n-6 and n-3 polyunsaturated fatty acids and levels of linoleic, dihomo-gamma-linolenic (DGLA), arachidonic, alpha-linolenic (ALA), eicosapentaenoic, docosapentaenoic, and docosahexaenoic (DHA) acid were increased after 12 weeks of supplementation. A significant decrease of the serum triglyceride level (P<0.001), glucose, insulin, calculated IR HOMA (P<0.05), and inflammatory markers (TNF-alpha, IL-6, and hs-CRP, P<0.001) was observed after seed mixture treatment. The serum levels of CRP and TNF-alpha negative correlate with ALA, DHA, and DGLA. Conclusion. Results of this study indicated that dietary milled sesame/pumpkin/flax seed mixture added to a habitual diet lowered triglyceride and CRP, TNF-alpha, IL-6 levels, affect glycemic control and improved fatty acid profile and pruritus symptoms in hemodialysis patients. |
| format | Article |
| id | doaj-art-db3bd5cdd395479fa393746f3701e8ca |
| institution | OA Journals |
| issn | 2356-6140 1537-744X |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | The Scientific World Journal |
| spelling | doaj-art-db3bd5cdd395479fa393746f3701e8ca2025-08-20T02:21:17ZengWileyThe Scientific World Journal2356-61401537-744X2014-01-01201410.1155/2014/563576563576Effects of Dietary Milled Seed Mixture on Fatty Acid Status and Inflammatory Markers in Patients on HemodialysisDanijela Ristic-Medic0Gordana Perunicic-Pekovic1Zorica Rasic-Milutinovic2Marija Takic3Tamara Popovic4Aleksandra Arsic5Marija Glibetic6Centre of Research Excellence in Nutrition and Metabolism, Institute for Medical Research, University of Belgrade, P.O. Box 102, 11000 Belgrade, SerbiaDepartment of Nephrology and Dialysis, Clinical Hospital Zemun, University of Belgrade, Belgrade, SerbiaDepartment of Endocrinology, Diabetes and Metabolism, Clinical Hospital Zemun, University of Belgrade, Belgrade, SerbiaCentre of Research Excellence in Nutrition and Metabolism, Institute for Medical Research, University of Belgrade, P.O. Box 102, 11000 Belgrade, SerbiaCentre of Research Excellence in Nutrition and Metabolism, Institute for Medical Research, University of Belgrade, P.O. Box 102, 11000 Belgrade, SerbiaCentre of Research Excellence in Nutrition and Metabolism, Institute for Medical Research, University of Belgrade, P.O. Box 102, 11000 Belgrade, SerbiaCentre of Research Excellence in Nutrition and Metabolism, Institute for Medical Research, University of Belgrade, P.O. Box 102, 11000 Belgrade, SerbiaBackground. Plant seeds have gained interest for their health benefits due to their fatty acid content. The objective of this study was to determine the effects of dietary consumption of milled sesame/pumpkin/flax seed mixture on glycemic control, serum lipids, phospholipid fatty acid status, and inflammatory factors in patients on hemodialysis. Methods. Thirty patients with well nutrition status (18 male, 12 female) were enrolled in the study. Participants consumed 30 g of milled sesame/pumpkin/flax (6 g/6 g/18 g, resp.) seeds mixture added to their habitual diet. Results. Total n-6 and n-3 polyunsaturated fatty acids and levels of linoleic, dihomo-gamma-linolenic (DGLA), arachidonic, alpha-linolenic (ALA), eicosapentaenoic, docosapentaenoic, and docosahexaenoic (DHA) acid were increased after 12 weeks of supplementation. A significant decrease of the serum triglyceride level (P<0.001), glucose, insulin, calculated IR HOMA (P<0.05), and inflammatory markers (TNF-alpha, IL-6, and hs-CRP, P<0.001) was observed after seed mixture treatment. The serum levels of CRP and TNF-alpha negative correlate with ALA, DHA, and DGLA. Conclusion. Results of this study indicated that dietary milled sesame/pumpkin/flax seed mixture added to a habitual diet lowered triglyceride and CRP, TNF-alpha, IL-6 levels, affect glycemic control and improved fatty acid profile and pruritus symptoms in hemodialysis patients.http://dx.doi.org/10.1155/2014/563576 |
| spellingShingle | Danijela Ristic-Medic Gordana Perunicic-Pekovic Zorica Rasic-Milutinovic Marija Takic Tamara Popovic Aleksandra Arsic Marija Glibetic Effects of Dietary Milled Seed Mixture on Fatty Acid Status and Inflammatory Markers in Patients on Hemodialysis The Scientific World Journal |
| title | Effects of Dietary Milled Seed Mixture on Fatty Acid Status and Inflammatory Markers in Patients on Hemodialysis |
| title_full | Effects of Dietary Milled Seed Mixture on Fatty Acid Status and Inflammatory Markers in Patients on Hemodialysis |
| title_fullStr | Effects of Dietary Milled Seed Mixture on Fatty Acid Status and Inflammatory Markers in Patients on Hemodialysis |
| title_full_unstemmed | Effects of Dietary Milled Seed Mixture on Fatty Acid Status and Inflammatory Markers in Patients on Hemodialysis |
| title_short | Effects of Dietary Milled Seed Mixture on Fatty Acid Status and Inflammatory Markers in Patients on Hemodialysis |
| title_sort | effects of dietary milled seed mixture on fatty acid status and inflammatory markers in patients on hemodialysis |
| url | http://dx.doi.org/10.1155/2014/563576 |
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