A Novel Molecularly Imprinted Electrochemiluminescence Sensor Based on Mxene Quantum Dots for Selective Detection of Oseltamivir in Biological Samples
Oseltamivir is a drug that has been widely used to prevent and treat influenza A and B. In this work, an ultrasensitive, simple, and novel electrochemiluminescence (ECL) sensor combined with molecularly imprinted polymers (MIP-ECL) based on a graphene-like two-dimensional material, Mxene quantum dot...
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2025-01-01
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| Series: | Molecules |
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| Online Access: | https://www.mdpi.com/1420-3049/30/1/152 |
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| author | Wei Guo Shiqiang Yan Chaoqiang Xiao Dayong Shi Qing Hua Xiaowen Hao Wenjuan Zhang Xuming Zhuang |
| author_facet | Wei Guo Shiqiang Yan Chaoqiang Xiao Dayong Shi Qing Hua Xiaowen Hao Wenjuan Zhang Xuming Zhuang |
| author_sort | Wei Guo |
| collection | DOAJ |
| description | Oseltamivir is a drug that has been widely used to prevent and treat influenza A and B. In this work, an ultrasensitive, simple, and novel electrochemiluminescence (ECL) sensor combined with molecularly imprinted polymers (MIP-ECL) based on a graphene-like two-dimensional material, Mxene quantum dots (MQDs) was constructed to selectively detect oseltamivir. A molecularly imprinted polymer membrane containing an oseltamivir template was constructed by electropolymerization and elution of modified MQDs on a glassy carbon electrode. Under optimized experimental conditions, the MIP-ECL sensor could detect oseltamivir in the range of 10<sup>−10</sup> to 10<sup>−6</sup> M (R<sup>2</sup> = 0.9816), with a low limit of detection of 6.5 × 10<sup>−11</sup> M (S/N = 3), and the recovery rates of oseltamivir in biological samples were 92.21–104.2%, with relative standard deviations of 3.70%~5.70%. The developed MIP-ECL sensor provides a new idea for detecting oseltamivir, which was successfully applied to the determination of oseltamivir in serum samples, indicating great potential for application in clinical diagnostics. |
| format | Article |
| id | doaj-art-db330b2577954587a57e9d696153038e |
| institution | Kabale University |
| issn | 1420-3049 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | MDPI AG |
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| series | Molecules |
| spelling | doaj-art-db330b2577954587a57e9d696153038e2025-01-10T13:19:02ZengMDPI AGMolecules1420-30492025-01-0130115210.3390/molecules30010152A Novel Molecularly Imprinted Electrochemiluminescence Sensor Based on Mxene Quantum Dots for Selective Detection of Oseltamivir in Biological SamplesWei Guo0Shiqiang Yan1Chaoqiang Xiao2Dayong Shi3Qing Hua4Xiaowen Hao5Wenjuan Zhang6Xuming Zhuang7Shandong Dyne Marine Biopharmaceutical Co., Ltd., Weihai 264300, ChinaShandong Dyne Marine Biopharmaceutical Co., Ltd., Weihai 264300, ChinaShandong Dyne Marine Biopharmaceutical Co., Ltd., Weihai 264300, ChinaShandong Dyne Marine Biopharmaceutical Co., Ltd., Weihai 264300, ChinaSchool of Chemistry and Chemical Engineering, Yantai University, Yantai 264005, ChinaSchool of Chemistry and Chemical Engineering, Yantai University, Yantai 264005, ChinaSchool of Chemistry and Chemical Engineering, Yantai University, Yantai 264005, ChinaSchool of Chemistry and Chemical Engineering, Yantai University, Yantai 264005, ChinaOseltamivir is a drug that has been widely used to prevent and treat influenza A and B. In this work, an ultrasensitive, simple, and novel electrochemiluminescence (ECL) sensor combined with molecularly imprinted polymers (MIP-ECL) based on a graphene-like two-dimensional material, Mxene quantum dots (MQDs) was constructed to selectively detect oseltamivir. A molecularly imprinted polymer membrane containing an oseltamivir template was constructed by electropolymerization and elution of modified MQDs on a glassy carbon electrode. Under optimized experimental conditions, the MIP-ECL sensor could detect oseltamivir in the range of 10<sup>−10</sup> to 10<sup>−6</sup> M (R<sup>2</sup> = 0.9816), with a low limit of detection of 6.5 × 10<sup>−11</sup> M (S/N = 3), and the recovery rates of oseltamivir in biological samples were 92.21–104.2%, with relative standard deviations of 3.70%~5.70%. The developed MIP-ECL sensor provides a new idea for detecting oseltamivir, which was successfully applied to the determination of oseltamivir in serum samples, indicating great potential for application in clinical diagnostics.https://www.mdpi.com/1420-3049/30/1/152oseltamivirMxenemolecular imprinting technologyelectrochemiluminescence |
| spellingShingle | Wei Guo Shiqiang Yan Chaoqiang Xiao Dayong Shi Qing Hua Xiaowen Hao Wenjuan Zhang Xuming Zhuang A Novel Molecularly Imprinted Electrochemiluminescence Sensor Based on Mxene Quantum Dots for Selective Detection of Oseltamivir in Biological Samples Molecules oseltamivir Mxene molecular imprinting technology electrochemiluminescence |
| title | A Novel Molecularly Imprinted Electrochemiluminescence Sensor Based on Mxene Quantum Dots for Selective Detection of Oseltamivir in Biological Samples |
| title_full | A Novel Molecularly Imprinted Electrochemiluminescence Sensor Based on Mxene Quantum Dots for Selective Detection of Oseltamivir in Biological Samples |
| title_fullStr | A Novel Molecularly Imprinted Electrochemiluminescence Sensor Based on Mxene Quantum Dots for Selective Detection of Oseltamivir in Biological Samples |
| title_full_unstemmed | A Novel Molecularly Imprinted Electrochemiluminescence Sensor Based on Mxene Quantum Dots for Selective Detection of Oseltamivir in Biological Samples |
| title_short | A Novel Molecularly Imprinted Electrochemiluminescence Sensor Based on Mxene Quantum Dots for Selective Detection of Oseltamivir in Biological Samples |
| title_sort | novel molecularly imprinted electrochemiluminescence sensor based on mxene quantum dots for selective detection of oseltamivir in biological samples |
| topic | oseltamivir Mxene molecular imprinting technology electrochemiluminescence |
| url | https://www.mdpi.com/1420-3049/30/1/152 |
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