Clostridioides difficile’s virulence requires efficient holin-mediated toxin secretion

Clostridioides difficile’s virulence requires efficient holin-mediated toxin secretion

Summary: The human pathogen Clostridioides difficile causes pseudomembranous colitis through release of the potent TcdA and TcdB toxins. These toxins lack canonical N-terminal secretion signal sequences for translocation across the bacterial membrane, suggesting alternate mechanisms of release inclu...

Full description

Saved in:
Bibliographic Details
Main Authors: Nicholas V. DiBenedetto, Marine Oberkampf, Aline Crouzols, Laura Cersosimo, Vladimir Yeliseyev, Lynn Bry, Johann Peltier, Bruno Dupuy
Format: Article
Language:English
Published: Elsevier 2025-06-01
Series:iScience
Subjects:
Bacteriology
Biological sciences
Microbiology
Natural sciences
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004225008478
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items

Similar Items