Exploring the critical role of PANoptosis in the pathogenesis of intervertebral disc degeneration: mechanisms and potential therapeutic targets

Exploring the critical role of PANoptosis in the pathogenesis of intervertebral disc degeneration: mechanisms and potential therapeutic targets

Intervertebral disc degeneration (IVDD), a leading cause of chronic low back pain, imposes a significant global health burden due to its association with aging, inflammation, and mechanical stress. Emerging evidence highlights programmed cell death (PCD) as a pivotal driver of IVDD progression. PANo...

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Bibliographic Details
Main Authors: Kaisheng Zhou, Mingyang Zou, Shaobo Wu, Wei Song, Hao Dong, Yanbo Dong, Haihong Zhang
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-06-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
PANoptosis
programmed cell death
nucleus pulposus cell
intervertebral disc degeneration
mechanism
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2025.1611936/full
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