Advances in Fecal Microbiota Transplantation for Gut Dysbiosis‐Related Diseases
Abstract This article provides an overview of the advancements in the application of fecal microbiota transplantation (FMT) in treating diseases related to intestinal dysbiosis. FMT involves the transfer of healthy donor fecal microbiota into the patient's body, aiming to restore the balance of...
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| Format: | Article |
| Language: | English |
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Wiley
2025-04-01
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| Series: | Advanced Science |
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| Online Access: | https://doi.org/10.1002/advs.202413197 |
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| author | Shuna Hou Jiachen Yu Yongshuang Li Duoyi Zhao Zhiyu Zhang |
| author_facet | Shuna Hou Jiachen Yu Yongshuang Li Duoyi Zhao Zhiyu Zhang |
| author_sort | Shuna Hou |
| collection | DOAJ |
| description | Abstract This article provides an overview of the advancements in the application of fecal microbiota transplantation (FMT) in treating diseases related to intestinal dysbiosis. FMT involves the transfer of healthy donor fecal microbiota into the patient's body, aiming to restore the balance of intestinal microbiota and thereby treat a variety of intestinal diseases such as recurrent Clostridioides difficile infection (rCDI), inflammatory bowel disease (IBD), constipation, short bowel syndrome (SBS), and irritable bowel syndrome (IBS). While FMT has shown high efficacy in the treatment of rCDI, further research is needed for its application in other chronic conditions. This article elaborates on the application of FMT in intestinal diseases and the mechanisms of intestinal dysbiosis, as well as discusses key factors influencing the effectiveness of FMT, including donor selection, recipient characteristics, treatment protocols, and methods for assessing microbiota. Additionally, it emphasizes the key to successful FMT. Future research should focus on optimizing the FMT process to ensure long‐term safety and explore the potential application of FMT in a broader range of medical conditions. |
| format | Article |
| id | doaj-art-db2d6f3c797148668030ae0b9aa3c4d9 |
| institution | DOAJ |
| issn | 2198-3844 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | Wiley |
| record_format | Article |
| series | Advanced Science |
| spelling | doaj-art-db2d6f3c797148668030ae0b9aa3c4d92025-08-20T03:04:17ZengWileyAdvanced Science2198-38442025-04-011213n/an/a10.1002/advs.202413197Advances in Fecal Microbiota Transplantation for Gut Dysbiosis‐Related DiseasesShuna Hou0Jiachen Yu1Yongshuang Li2Duoyi Zhao3Zhiyu Zhang4Department of Orthopedics The Fourth Affiliated Hospital of China Medical University China Medical University Liao Ning Shen Yang 110032 P. R. ChinaDepartment of Orthopedics The Fourth Affiliated Hospital of China Medical University China Medical University Liao Ning Shen Yang 110032 P. R. ChinaDepartment of general surgery The Fourth Affiliated Hospital of China Medical University China Medical University Liao Ning Shen Yang 110032 P. R. ChinaDepartment of Orthopedics The Fourth Affiliated Hospital of China Medical University China Medical University Liao Ning Shen Yang 110032 P. R. ChinaDepartment of Orthopedics The Fourth Affiliated Hospital of China Medical University China Medical University Liao Ning Shen Yang 110032 P. R. ChinaAbstract This article provides an overview of the advancements in the application of fecal microbiota transplantation (FMT) in treating diseases related to intestinal dysbiosis. FMT involves the transfer of healthy donor fecal microbiota into the patient's body, aiming to restore the balance of intestinal microbiota and thereby treat a variety of intestinal diseases such as recurrent Clostridioides difficile infection (rCDI), inflammatory bowel disease (IBD), constipation, short bowel syndrome (SBS), and irritable bowel syndrome (IBS). While FMT has shown high efficacy in the treatment of rCDI, further research is needed for its application in other chronic conditions. This article elaborates on the application of FMT in intestinal diseases and the mechanisms of intestinal dysbiosis, as well as discusses key factors influencing the effectiveness of FMT, including donor selection, recipient characteristics, treatment protocols, and methods for assessing microbiota. Additionally, it emphasizes the key to successful FMT. Future research should focus on optimizing the FMT process to ensure long‐term safety and explore the potential application of FMT in a broader range of medical conditions.https://doi.org/10.1002/advs.202413197clinical efficacyClostridioides difficile infectionfecal bacteria transplantationintestinal floraintestinal diseases |
| spellingShingle | Shuna Hou Jiachen Yu Yongshuang Li Duoyi Zhao Zhiyu Zhang Advances in Fecal Microbiota Transplantation for Gut Dysbiosis‐Related Diseases Advanced Science clinical efficacy Clostridioides difficile infection fecal bacteria transplantation intestinal flora intestinal diseases |
| title | Advances in Fecal Microbiota Transplantation for Gut Dysbiosis‐Related Diseases |
| title_full | Advances in Fecal Microbiota Transplantation for Gut Dysbiosis‐Related Diseases |
| title_fullStr | Advances in Fecal Microbiota Transplantation for Gut Dysbiosis‐Related Diseases |
| title_full_unstemmed | Advances in Fecal Microbiota Transplantation for Gut Dysbiosis‐Related Diseases |
| title_short | Advances in Fecal Microbiota Transplantation for Gut Dysbiosis‐Related Diseases |
| title_sort | advances in fecal microbiota transplantation for gut dysbiosis related diseases |
| topic | clinical efficacy Clostridioides difficile infection fecal bacteria transplantation intestinal flora intestinal diseases |
| url | https://doi.org/10.1002/advs.202413197 |
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